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Amino
The CCL27
Robust anti
immunotherapy
HSD17B13
Memory Enhancement by Oral Administration of Extract of Eleutherococcus senticosus Leaves and Active Compounds Transferred in the Brain PMID 31121888
(3R,5R,6S)
Doxorubicin disaccharide analogue apoptosis
Apigenin 7
3',5'
B cell
Equine metabolic investigation of the phosphodiesterase
3′
Z164597606
HIF/HIF Prolyl
PD
α
Dual
CREB3L1 蛋白, Human (HEK293, His)
Avarone ((+)
YLT192
phospholipid
TUFM is involved in Alzheimer's disease
A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis PMID 18313377
Myostatin inhibits eEF2K
Interleukin
Tanshinone I limits inflammasome activation of macrophage via docking into Syk to alleviate DSS
Agaric acid reduces Salmonella biofilm formation by inhibiting flagellar motility PMID 33447808
Araf
ERAB 抗体 (YA3343)（ERAB Antibody (YA3343)）
Propofol Modulates Microglial Glucose Metabolism Via the AMPK/HIF
Betulinic acid inhibits pyroptosis in spinal cord injury by augmenting autophagy via the AMPK
GW788388 452342
Lipoxamycin hemisulfate 11075
DARS2 overexpression is associated with PET/CT metabolic parameters and affects glycolytic activity in lung adenocarcinoma PMID 37626419
Indoxyl sulfate
Pramlintide, an antidiabetic, is antineoplastic in colorectal cancer and synergizes with conventional chemotherapy PMID 29551915
An amphiphilic dendrimer as a light
One
Transforming growth factor beta receptors
Sequential Release HydroLipo System for STING Gene Epigenetic Reprogramming and Immune Activation in Glioblastoma PMID 39661716
N
Aftins increase amyloid
CCR8 antagonist 2 2756350
Brincidofovir is highly efficacious in controlling adenoviremia in pediatric recipients of hematopoietic cell transplant PMID 28153824
千金藤素 (Standard)
STAT3 signaling
卡铂
Vanillylamine
巴恩斯迷宫实验
Mfn2
SNIPER(TACC3) induces cytoplasmic vacuolization and sensitizes cancer cells to Bortezomib PMID 28192613
Antibacterial agent 281
Inhibition of HIV
(S)
Lisinopril
TFRC 蛋白, Human (HEK293)
HD5 798569
LOX
PSMC3 相互作用蛋白（PSMC3IP）基因
Licochalcone B inhibits growth and induces apoptosis of human non
蛋白酶体 20S 亚基 beta 10（PSMB10）基因
STAT3 signaling
2,4,5
Fructose
Targeting heme Oxygenase
A Quinolinone Compound Inhibiting the Oligomerization of Nucleoprotein of Influenza A Virus Prevents the Selection of Escape Mutants PMID 32204549
Zanamivir oral delivery enhanced plasma and lung bioavailability in rats PMID 24009875
Foretinib (GSK1363089), a multi
Geniposide exhibits anticancer activity to medulloblastoma cells by downregulating microRNA
Clinical disease and lung lesions in calves experimentally inoculated with Histophilus somni five days after metaphylactic administration of tildipirosin or tulathromycin PMID 27027834
Triflumezopyrim 1263133
A novel inhibitor of class IIa histone deacetylases attenuates collagen
11(S),16(R)
Engineering a promiscuous prenyltransferase for selective biosynthesis of an undescribed bioactive cannabinoid analog PMID 39905239
Functionalized N,N
Krüppel
A peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancer PMID 24525233
Identification, by gene expression profiling analysis, of novel gene targets in Staphylococcus aureus treated with betulinaldehyde PMID 23385141
Use of chlorotoxin for targeting of primary brain tumors PMID 9809993
Endometrial cancer (EC) derived G3BP1 overexpression and mutant promote EC tumorigenesis and metastasis via SPOP/ERα axis PMID 37904149
Satralizumab in the treatment of neuromyelitis optica spectrum disorder PMID 33167776
Physiological roles of the pantothenate kinases PMID 25109998
AR493 1290546
EGFR Inhibition Blocks Palmitic Acid
2,6
Antagonism of the antihypertensive action of guanethidine sulfate by desipramine hydrochloride PMID 5630743
DB008 2991637
7
Cyp2s1 Mouse Pre
Androgen deprivation upregulates SPINK1 expression and potentiates cellular plasticity in prostate cancer PMID 31959826
Fatty acids modulate the expression of pyruvate kinase and arachidonate
Boc
Polyamine metabolism dysregulation contributes to muscle fiber vulnerability in ALS PMID 39932195
Supramolecular nanotherapeutics enable metabolic reprogramming of tumor
Synthesis of 4
mellitus
In vitro Studies and Clinical Observations Imply a Synergistic Effect Between Epstein
LncRNA LINC00961 regulates endothelial‑mesenchymal transition via the PTEN‑PI3K‑AKT pathway PMID 35656895
Melengestrol acetate 2919
Novobiocin sodium 1476
2’
The AhR
Polymyxin S1
N
(S)
Suclg1 Mouse Pre
ADH
RIP2/NF
HADA hydrochloride 2253733
EG1
Glucosylceramide Synthase (GCS)
Dichloroacetate enhances the anti
CR2 Human Pre
Sinulatumolin E 2570255
Bivalirudin a review PMID 16013985
The BET PROTAC inhibitor GNE
D
Foxy
LTBP2 regulates cisplatin resistance in GC cells via activation of the NF
GSK951
Affinity
In Silico Analysis to Identify Molecular Targets for Chemicals of Concern The Case Study of Flocoumafen, an Anticoagulant Pesticide PMID 33729601
Cpa2
Phospho
Intercellular adhesion molecule
An antitumor peptide RS17
BTI
Ganglioside GD1b Disodium Salt (Bovine Brain) 19553
Novel and Emerging Therapies for Inflammatory Bowel Disease PMID 33935763
BRCC3 promotes activation of the NLRP6 inflammasome following cerebral ischemia/reperfusion (I/R) injury in rats PMID 33979701
sodium channel inhibitor
Glutor, a Glucose Transporter Inhibitor, Exerts Antineoplastic Action on Tumor Cells of Thymic Origin Implication of Modulated Metabolism, Survival, Oxidative Stress, Mitochondrial Membrane Potential, pH Homeostasis, and Chemosensitivity PMID 35847943
Helveticoside 630
C 型蛋白酪氨酸磷酸酶受体（PTPRC）基因
Isosilybin B a potential novel therapeutic agent with hepatoprotective, anticancer and antifibrotic properties PMID 40779034
Hydroxy
Macelignan attenuates LPS
Maraviroc 376348
BDP 650/665 X NHS ester 1616842
Nampt activator
Mal
Targeting PFKFB4 Biomimetic Codelivery System Synergistically Enhances Ferroptosis to Suppress Small Cell Lung Cancer and Augments the Efficacy of Anti
4
The potent M1 receptor allosteric agonist GSK1034702 improves episodic memory in humans in the nicotine abstinence model of cognitive dysfunction PMID 22932339
Phospho
FGF8 promotes lipid droplet accumulation via the FGFR1/p
Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer PMID 28965760
Benzgalantamine (GLN
Biodegradable Cationic and Ionizable Cationic Lipids A Roadmap for Safer Pharmaceutical Excipients PMID 36610004
NGFI
Effect of AP102, a subtype 2 and 5 specific somatostatin analog, on glucose metabolism in rats PMID 28822091
Expanding the Solvent/Protein Region Occupation of the Non
Histone deacetylases
Cletoquine oxalate 14142
Ebola virus VP24 蛋白 (AHX24653, His)
AGI
ALDH2 Hampers Immune Escape in Liver Hepatocellular Carcinoma through ROS/Nrf2
LY3522348 2568608
Sulfisomidin
1
IFN
Antibacterial agent 252 hydrochloride 2841472
KLRB1 Human Pre
L
MCE
D
5& 039;
Sarsasapogenin ameliorates diabetes
hCAI/II
The HDAC2
8
Genome
10,12
PP
Itgav Mouse Pre
4
Characterization of functionally relevant G protein
Capsorubin 470
Identification of benzamides derivatives of norfloxacin as promising microRNA
Phenazine
(S)
The combination of pro
细胞周期蛋白依赖性激酶抑制因子 2C（CDKN2C）基因
PI4K
淋巴细胞抗原 96（LY96）基因
Comprehensive analysis of the correlation of the pan
Enhancement of hexokinase II inhibitor
Dorsomorphin
跨膜蛋白 160（TMEM160）基因
Retinoic acid receptors
Sodium dihydrogen phosphate monohydrate, for molecular biology
4
dose
QMT
Design and synthesis of novel benzo[d]oxazol
Synthesis and structure
Discovery of 6
Macrophage A2aR Alleviates LPS
AZ 6102
CDK5 inhibitor 20
Coumarin 7 27425
Brigatinib, an anaplastic lymphoma kinase inhibitor, abrogates activity and growth in ALK
caspase
5& 039;
2
E2F activity determines mitosis versus whole
The phorbol 12
MEK ligand
APX
Substitution of SERCA2 Cys674 aggravates cardiac fibrosis by promoting the transformation of cardiac fibroblasts to cardiac myofibroblasts PMID 35809651
Distinct AMPK
detergent
Targeting the HuR/E2F7 axis synergizes with bortezomib against multiple myeloma PMID 40133626
Treatment with olopatadine and naphazoline hydrochloride reduces allergic conjunctivitis in mice through alterations in inflammation, NGF and VEGF PMID 26936233
Design, synthesis and biological evaluation of novel 4
Mechanism of desuccinylation of G6PD mediated by SIRT7 to promote vitiligo disease progression PMID 39092715
TR
IL
Aristolochic acid I promotes renal tubulointerstitial fibrosis by activating the mannan
manufacturing process
Polyoxometalates Ameliorate Metabolic Dysfunction
The AMPK
Resistin alleviates lipopolysaccharide
Exosomes derived from schwann cells alleviate mitochondrial dysfunction and necroptosis after spinal cord injury via AMPK signaling pathway
Activation of AMPK inhibits cervical cancer growth by hyperacetylation of H3K9 through PCAF PMID 38831454
DT
ROS
LXR
VEGFR
STAT3
7
Plasma membrane accessible cholesterol is regulated by ACC1 and lipid droplets PMID 40909529
AZT triphosphate tetraammonium 106060
Enterobacter ludwigii protects DSS
Recent progress in the identification of adenosine monophosphate
17β
RNA m6A dynamics promote transcription and RNA stability of bivalent genes during iPSC
Tricin Delays Aging and Enhances Muscle Function via Activating AMPK
β
allergic
Clusterin ameliorates endothelial dysfunction in diabetes by suppressing mitochondrial fragmentation PMID 31614179
Hepatic Polarized Differentiation Promoted the Maturity and Liver Function of Human Embryonic Stem Cell
BMP
Fludarabine phosphate 75607
Organoid
Anti
Crucial Role of Lateral Size for Graphene Oxide in Activating Macrophages and Stimulating Pro
Polistes mastoparan
Ulipristal acetate 126784
A small
CCT241533 1262849
DNCA
Benzyl
Karenitecin (Cositecan)
A novel cuproptosis
Dehydroepiandrosterone exacerbates nigericin
Luteolin alleviates muscle atrophy, mitochondrial dysfunction and abnormal FNDC5 expression in high fat diet
γ
FXR activation alleviates tacrolimus
Forsythoside A regulates autophagy and apoptosis through the AMPK/mTOR/ULK1 pathway and alleviates inflammatory damage in MAC
CD96 分子（CD96）基因
Hsp90
Oxytetracycline dihydrate (Standard) (土霉素二水合物 (Standard))
Role of type 1 IFNs in antiglioma immunosurveillance
Vobramitamab 2490556
Sigma Receptor
CD3D
TCL1 家族 AKT 共激活因子 B（TCL1B）基因
Amiloride
Rotating culture regulates the formation of HepaRG
IL
The mechanistic and functional profile of the therapeutic anti
Circular RNA CircHIPK3 Promotes Gemcitabine Sensitivity in Bladder Cancer PMID 32194801
Dynamin I 抗体 (YA4817)（Dynamin I Antibody (YA4817)）
Development of polyoxyethylene (2) oleyl ether
Alpinetin ameliorates bleomycin
Mechanistic study on ligustilide modulation of the TLR4/NF
11
NMS
Synthesis and Preclinical Evaluation of an 18F
SNGH16 regulates cell autophagy to promote Sorafenib Resistance through suppressing miR
N6
Effect of Eupatorium odoratum on blood coagulation PMID 1783877
p21 activated kinases
EGFR
Trilobolide
T cell
Potent antimyeloma activity of the novel bromodomain inhibitors I
MCE
Sulindac
SALL4 activates TGF
HSD17B13
Interleukin 12 a key modulator of immune function PMID 7911046
triacylglyceride
Firmonertinib 1869057
Cenzestotug 3014361
Small Molecule CXCR3 Antagonists PMID 26535614
Formycin B 13877
HER4/HER2
MUT056399 1269055
Novel tryptanthrin derivatives with benzenesulfonamide substituents Design, synthesis, and anti
Blockage of TRPV4 Downregulates the Nuclear Factor
Evaluation of anti
FRAX597, a small molecule inhibitor of the p21
Adipic acid
Sodium phosphate
Aminooxyacetic acid hemihydrochloride leads to decreased intracellular ATP levels and altered cell cycle of prostate cancer cells by suppressing energy metabolism PMID 37801901
1
TFE3, a potential therapeutic target for Spinal Cord Injury via augmenting autophagy flux and alleviating ER stress PMID 32802192
MiR
FO
Selection and characterization of hepatitis C virus replicons dually resistant to the polymerase and protease inhibitors HCV
Esmolol acid hydrochloride 83356
Gastroprotective Activities of Sennoside A and Sennoside B via the Up
Expression analysis of early response
Synergistic anticancer activity of combined ATR and ribonucleotide reductase inhibition in Ewing's sarcoma cells PMID 37097390
Di
Triptolide Suppresses Glomerular Mesangial Cell Proliferation in Diabetic Nephropathy Is Associated with Inhibition of PDK1/Akt/mTOR Pathway PMID 29104493
Glaucocalyxin B induces apoptosis and autophagy in human cervical cancer cells PMID 27356884
FAP 抗体 (YA6033)（FAP Antibody (YA6033)）
Property Focused Structure
Prenatal developmental toxicity study of 2,4
Synthesis and evaluation of monoamidoxime derivatives toward new antileishmanial compounds PMID 21555166
Siplizumab 288392
UHPLC
gamma
1,1,1
Novel series of 6
N
羟基波生坦杂质
MHV
A novel method for exploration and prediction of the bioactive target of rice bran
Pazopanib
DL
Senescence
APL
SRI
Vanucizumab 1448221
Distinct functions of BMP4 and GDF5 in the regulation of chondrogenesis PMID 15048875
RGFP966 1357389
Diphenyleneiodonium ameliorates acute liver rejection during transplantation by inhibiting neutrophil extracellular traps formation in vivo PMID 34216758
Combination of multivalent DR5 receptor clustering agonists and histone deacetylase inhibitors for treatment of colon cancer PMID 39489464
Lumateperone
Histone modification landscape and the key significance of H3K27me3 in myocardial ischaemia/reperfusion injury PMID 36808292
A first
Neuroprotective effects of P7C3 against spinal cord injury in rats PMID 31718264
LDN
DNA methylation
ATF4 renders human T
Spinal glial TLR4
The Microbial Composition of Penaeid Shrimps' Hepatopancreas Is Modulated by Hemocyanin PMID 34670821
Lycorine relieves the CCl4
Acetylshikonin stimulates glucose uptake in L6 myotubes via a PLC
Kv3 modulator 2 2101321
hsa
Almotriptan hydrochloride 154323
AQP3 Influences Unexplained Recurrent Abortion by Regulating Trophoblast Cell Migration and Invasion via the METTL14/IGF2BP1/AQP3/PI3K/AKT Pathway PMID 39878312
The synthesis and analysis of [phenyl
Piperonyl butoxide activates c
IL
Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK
Thymol
N
Methyl 3(R,S)
Selective Inhibitors of Fibroblast Activation Protein (FAP) with a (4
SRT3190
跨膜 4 域 A1（Ms4a1）基因
Hypoxia
Brucella Infection Regulates Thioredoxin
TGR5 supresses cGAS/STING pathway by inhibiting GRP75
New challenges and inspired answers for anticancer drug discovery and development PMID 24014883
Oxidative Stress Promotes Liver Cancer Metastasis via RNF25
FRAX
Decitabine suppresses tumor growth by activating mouse mammary tumor virus and interferon
Three dimensional pharmacophore modeling of human CYP17 inhibitors. Potential agents for prostate cancer therapy PMID 12773039
Plasminogen Activator Inhibitor 1 Controls Abdominal Aortic Aneurism Formation via the Modulation of TGF
Quercetin 3,7
Oncogenic Chromatin Modifier KAT2A Activates MCT1 to Drive the Glycolytic Process and Tumor Progression in Renal Cell Carcinoma PMID 34268311
Synthesis and SAR study of diphenylbutylpiperidines as cell autophagy inducers PMID 21126871
CLDN18.2 CAR
CYP51
Activity of triciribine and triciribine
Mitochondrial metabolism and epigenetic crosstalk drive the SASP PMID 39678326
FHxSA
Stearate sodium 822
Aztreonam
Carbonic anhydrase inhibitors X
L
1
Vitamin D3 suppresses the cholesterol homeostasis pathway in patient
Discovery and SAR of cinnolines/quinolines as liver X receptor (LXR) agonists with binding selectivity for LXRbeta PMID 19394832
Structural basis for the recognition of oxidized phospholipids in oxidized low density lipoproteins by class B scavenger receptors CD36 and SR
Boc
GSK2837808A (Standard)
SaeR Inhibitor
Bfl
Sirtuin
Biomarkers of drug
NFAT Inhibitor 1
M701
cathepsin
JW 55
Loss of Brcc3 in Zebrafish Embryos Increases Their Susceptibility to DNA Damage Stress PMID 39596176
A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice PMID 22440753
Hexavalent chromium triggers hepatocytes premature senescence via the GATA4/NF
Bispecific Nanobody
cell
NFAT Inhibitor
BMS
CGK
CGK733
BMS 687453
NFAT Inhibitor
Caustic potash (pellets), meets analytical specification of Ph. Eur. BP
5,7,3',4'
Yukocitrine 145940
The ZAR1 resistosome is a calcium
Klrb1 Mouse Pre
Sulbactam a beta
Amlodipine
Regulation of PD
Exploring potential targets and mechanisms of renal tissue damage caused by N
Emerging and Novel Functions of Complement Protein C1q PMID 26175731
BMS687453
MiR
A Tetrahedral Framework DNA
CD70 抗体 (YA4697)（CD70 Antibody (YA4697)）
2
精子细胞核周 RNA 结合蛋白（STRBP）基因
(+)
Sarecycline 1035654
Duchenne muscular dystrophy treatment with lentiviral vector containing mini
Desaminotyrosine is a redox
Serum from patients with oral squamous cell carcinoma remodels the tumor immune escape ecological niche by promoting regulatory T‑cell differentiation and T‑cell exhaustion PMID 40878964
Structure guided design of potential inhibitors of human calcium
Conversion of ATP to adenosine by CD39 and CD73 in multiple myeloma can be successfully targeted together with adenosine receptor A2A blockade PMID 32409420
Fyn
Assessment of the disruption effects of tetrabromobisphenol A and its analogues on lipid metabolism using multiple in vitro models PMID 38870736
Anti
Protein disulfide isomerase family member 4 promotes triple
AHL modulator
肌醇六磷酸激酶 2（IP6K2）基因
Benidipine Hydrochloride Inhibits NLRP3 Inflammasome Activation by Inhibiting LPS
(S)
Fluorofenidone 848353
Estrone sulfate sodium 438
HCCS
干扰素λ3（IFNL3）基因
Life in the fast lane Functional consequences of male
Transcriptional regulation of microRNA
Gut microbial and metabolomics profiles reveal the potential mechanism of fecal microbiota transplantation in modulating the progression of colitis
Synthesis, cytostatic activity and ADME properties of C
mTORC1 senses glutamine and other amino acids through GCN2 PMID 40691417
Chemical Tools Based on the Tetrapeptide Sequence of IL
cell therapy
N
Erythrocyte membrane protein band 4.1
RGFP966, a histone deacetylase 3 inhibitor, promotes glioma stem cell differentiation by blocking TGF
Age
SP
Design, synthesis and in vitro evaluation of novel uni
Activation of the p53 signaling pathway by piRNA
Urinary 7alpha
SLC25A3 negatively regulates NLRP3 inflammasome activation by restricting the function of NLRP3 PMID 38552738
Discovery and Optimization of Highly Selective Inhibitors of CDK5 PMID 35143203
(Trifluoromethyl)uracil
(±)
Carbocisteine attenuates hydrogen peroxide
LRRK2 抗体 (YA4329)（LRRK2 Antibody (YA4329)）
Homocysteine interferes with Ndufa1 leading to mitochondrial dysfunction through repression of the NAD+/Sirt1 pathway in the brain a possible link between hyperhomocysteinemia and neurodegeneration PMID 40624018
USP28
apopotsis
New therapy targeting differential androgen receptor signaling in prostate cancer stem/progenitor vs. non
Spinal apolipoprotein E is involved in inflammatory pain via regulating lipid metabolism and glial activation in the spinal dorsal horn PMID 38071369
5
ADAR promotes USP38 auto
Chrysoeriol a natural RANKL inhibitor targeting osteoclastogenesis and ROS regulation for osteoporosis therapy PMID 39755833
BnO
Delgocitinib ethanolate 2064338
Notch inhibition allows oncogene
Upregulated mGluR5 induces ER stress and DNA damage by regulating the NMDA receptor subunit NR2B PMID 34908130
Mitophagy promotes resistance to BH3 mimetics in acute myeloid leukemia PMID 37088914
Activation of T lymphocytes via monoclonal antibodies against rat cell surface antigens with particular reference to CD2 antigen PMID 2576418
Design, synthesis and biological evaluation of novel 4
Ruboxistaurin 169939
Platelet autophagic machinery involved in thrombosis through a novel linkage of AMPK
Didymin alleviates metabolic dysfunction
Preclinical Evaluation of 89Zr
(Rac)
URAT1 inhibitor 13 2816864
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