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CS
Diltiazem
renoprotective
Cafestol (Standard)
Periplocoside F 119902
NF
Rifamycin B (4
Boc
Boc
11
Gfi1 Mouse Pre
Synergistic, cytotoxic and apoptotic activities of olmesartan with NF
Chk2 sustains PLK1 activity in mitosis to ensure proper chromosome segregation PMID 39737931
Antibacterial and antitumoral properties of 1,2,3
Adjudin protects blood
6
5
OTUB1 enhances fatty acid oxidation in APAP
KRASG12C
Polyethylene glycol octadecyl ether (n～20)
LRRC8A as a central mediator promotes colon cancer metastasis by regulating PIP5K1B/PIP2 pathway PMID 38350542
HDAC9 Deficiency Upregulates cGMP
Ferroptosis A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease PMID 28985560
C3 Ceramide 362678
Hemicellulase 9025
SB 525334 356559
A whole
Abciximab 143653
Slow Metabolism
Anti
Kinetics and brain uptake of S 9795, a new xanthine derivate, in rats PMID 2612517
Evidence that the receptor for C4a is distinct from the C3a receptor PMID 9476119
Bisphenol S exacerbates CRC progression through dual mechanisms of immune microenvironment reprogramming and SLC4A2
Propionyl CoA
Enthalpy
cis (2,3)
1
ICAM1/CD54 抗体 (YA352)（ICAM1/CD54 Antibody (YA352)）
YC
A novel pharmacologic inhibitor of the NLRP3 inflammasome limits myocardial injury after ischemia
New AIDS study suppresses T cells to stop viral growth PMID 11364396
Poly(ADP
Inhibition of IP3 (Inositol 1,4,5
Hippocampus
4
AGT 抗体 (YA3593)（AGT Antibody (YA3593)）
Punicalin 65995
Novel Small
Cytotoxic lavandulyl flavanones from Sophora flavescens PMID 10843587
Lysine vasopressin
Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS
URAT1
Fused chromeno and quinolino[1,8]naphthyridines Synthesis and biological evaluation as topoisomerase I inhibitors and antiproliferative agents PMID 33962152
A novel series of highly potent benzimidazole
TRIM21 deficiency protects against atrial inflammation and remodeling post myocardial infarction by attenuating oxidative stress PMID 36996623
小泛素样修饰符 1（SUMO1）基因
162605
Methylglyoxal induces endothelial cell apoptosis and coronary microvascular dysfunction through regulating AR
Gamcemetinib 1887069
Modulation by flunisolide of tumor necrosis factor
Data mining reveals novel gene drivers of lenvatinib resistance in hepatocellular carcinoma PMID 40460973
Antibody
Synthesis of pyrrolo[3,2
Long non
双缩脲试验
Ibuprofen attenuates the inflammatory response to Pseudomonas aeruginosa in a rat model of chronic pulmonary infection. Implications for antiinflammatory therapy in cystic fibrosis PMID 2153353
去氟可特
Effects of amiloride, benzamil, and alterations in extracellular Na+ on the rat afferent arteriole and its myogenic response PMID 18495800
Development of a Caco
Structure, Biosynthesis, and Bioactivity of Photoditritide from Photorhabdus temperata Meg1 PMID 31799840
N
PRA1 域家族成员 2（PRAF2）基因
Descarboethoxyloratadine
LIM Kinase (LIMK)
ML323, a USP1 inhibitor triggers cell cycle arrest, apoptosis and autophagy in esophageal squamous cell carcinoma cells PMID 35654870
Banoxantrone dihydrochloride 252979
CV
competitive
3
Exploiting oncogene
Trifluridine selectively inhibits cell growth and induces cell apoptosis of triple
Vapendavir
Upregulation of ISG15 induced by MAPT/tau accumulation represses autophagic flux by inhibiting HDAC6 activity a vicious cycle in Alzheimer disease PMID 39635882
Chemogenetic silencing of the subiculum blocks acute chronic temporal lobe epilepsy PMID 39614352
Hybrid EMT Phenotype and Cell Membrane Tension Promote Colorectal Cancer Resistance to Ferroptosis PMID 39985376
Deapioplatycodin D inhibits glioblastoma cell proliferation by inducing BNIP3L
Dengue Virus
Network Medicine
强力霉素
β
曲伐沙星甲磺酸盐
5
NELFA and BCL2 induce the 2C
PSD
鬼罂粟提取物 (Papaver orientale L.)
Promotion of Cell Proliferation through Inhibition of Cell Autophagy Signalling Pathway by Rab3IP is Restrained by MicroRNA
Melatonin activates Parkin translocation and rescues the impaired mitophagy activity of diabetic cardiomyopathy through Mst1 inhibition PMID 30063115
Inhibition of CDC27 O
Homogeneous Polyporus polysaccharide exerts anti
ADV3
Bub1 and Bub3 regulate metabolic adaptation via macrolipophagy in Drosophila PMID 37027296
Reciprocal regulation of NRF2 by autophagy and ubiquitin
A novel antibody
Impaired autophagy
tuberculosis
Calcineurin/NFAT1/Smad2 signaling regulates microglial autophagy that contributes to neuroinflammation and cognitive deficit in mice with sepsis
Electroacupuncture at Bilateral Zusanli Points (ST36) Protects Intestinal Mucosal Immune Barrier in Sepsis PMID 26346309
Gut microbially produced tryptophan metabolite melatonin ameliorates osteoporosis via modulating SCFA and TMAO metabolism PMID 38618998
Immunotherapy with STING and TLR9 agonists promotes synergistic therapeutic efficacy with suppressed cancer
In Vivo Pharmacodynamic Target Assessment of Delafloxacin against Staphylococcus aureus, Streptococcus pneumoniae, and Klebsiella pneumoniae in a Murine Lung Infection Model PMID 27216072
aryloxy phosphoramidate
Aloxistatin
盐酸四环素
A
Caveolin
Rutin attenuates Sorafenib
Sodium chloride, for cell culture 7647
A novel strategy for the protective effect of ginsenoside Rg1 against ovarian reserve decline by the PINK1 pathway PMID 39862058
Galangin alleviated myocardial ischemia
Butylphthalide may inhibit blood
金罂粟提取物 (Stylophorum lasiocarpum (Oliv.) Fedde)
FURIN suppresses the progression of atherosclerosis by promoting macrophage autophagy PMID 37093709
Characterization of the effect of AG337, a novel lipophilic thymidylate synthase inhibitor, on human head and neck and human leukemia cell lines PMID 10568835
Oncogene OSTM1 Promotes Gastric
Timosaponin BII improved osteoporosis caused by hyperglycemia through promoting autophagy of osteoblasts via suppressing the mTOR/NFκB signaling pathway PMID 33992678
RBBP4 A novel diagnostic and prognostic biomarker for non
Development of an autophagy
Methamphetamine and Methamphetamine
RTN4/Nogo
Cadherin
FTD
Autophagy Protects Ocular Surface Against Overactivated Inflammation by Degrading Retinoic Acid
Inhibition of Hypoxia
Pestivirus bovine viral diarrhea virus infection triggers lipophagy through the AMPK
大罂粟提取物 (Romneya coulteri Harv.)
Biotin
Isoginkgetin
ROS
Melanoma
Redox environment in stem and differentiated cells A quantitative approach PMID 28426982
Adropin ameliorates behavioral seizures and the relevant neuroinflammation, oxidative stress, and neural damage in a rat model of pentylenetetrazole
DYSP
Loss of NAPRT1 expression by tumor
Challenges in modern drug discovery a case study of boceprevir, an HCV protease inhibitor for the treatment of hepatitis C virus infection PMID 18193821
Development of a Suicide Inhibition
Integrative discovery of treatments for high
Endothelium
(rac./meso)
Ifna4 Rat Pre
Astragalus polysaccharides ameliorate osteoarthritis via inhibiting apoptosis by regulating ROS
Repurposing pharmaceuticals for Alzheimer's treatment via adjusting the lactoferrin interacting proteins PMID 40379164
Gibberellin A1 545
Umbilical cord mesenchymal stem cell
Il11 Mouse Pre
Telocinobufagin inhibits the epithelial
Activin
Sigma compounds derived from phencyclidine identification of PRE
Protocol for Probing Regulated Lysosomal Activity and Function in Living Cells PMID 33377026
A Novel Role of Chromodomain Protein CBX8 in DNA Damage Response PMID 27555324
Mitigating PCOS progression The protective effect of C
microRNA
Elvitegravir
Decoy
OX40 Ligand/TNFSF4 蛋白, Human (Biotinylated, HEK293, N
BPK
Trigonelline chloride 6138
Norcantharidin liposome emulsion hybrid delivery system enhances PD
Routine alpha
Design, synthesis, and biological evaluation of N1
NO2A
5
Targeting of XJB
ESC
MicroRNA
miR
TNF
Qianggan Ruanjian Pill ameliorates liver fibrosis through regulation of the TGF
JSH
Ractopamine
FOXO
The C
Biotin uptake by T47D breast cancer cells functional and molecular evidence of sodium
WKYMVm ameliorates obesity by improving lipid metabolism and leptin signalling PMID 37603580
GATD3A
1,2
METTL3
Synthesis, in vitro evaluation and molecular modelling of naphthalimide analogue as anticancer agents PMID 23994328
Zamerovimab 2419087
SDCBP Orchestrated Gastric Cancer Aggression Through Epithelial
Discovery of a Potent, Orally Bioavailable PI4KIIIβ Inhibitor (UCB9608) Able To Significantly Prolong Allogeneic Organ Engraftment in Vivo PMID 29952567
Matrine Inhibits the Wnt3a/β
C2
Imidazolyl benzimidazoles and imidazo[4,5
2
Effect of oleocanthal and its derivatives on inflammatory response induced by lipopolysaccharide in a murine chondrocyte cell line PMID 20201078
Protective effect of dihydroartemisinin in inhibiting senescence of myeloid
Peramivir Phosphonate Derivatives as Influenza Neuraminidase Inhibitors PMID 27167096
N
Gilvocarcin M
Comparative effects of simvastatin (MK
Thalidomide
Propofol Attenuates Hypoxia/Reoxygenation
Indolylarylsulfones bearing natural and unnatural amino acids. Discovery of potent inhibitors of HIV
Berberine as a novel ACSL4 inhibitor to suppress endothelial ferroptosis and atherosclerosis PMID 38971008
CC chemokine receptor
Probimane 108093
Methyl pseudolarate B 82508
Pacsin2
Zotepine
Antitumorigenic
Activation of mannose receptor C type 1 in macrophages improves renal fibrosis through mediating fibronectin endocytosis PMID 40164332
Novel leucine ureido derivatives as inhibitors of aminopeptidase N (APN) PMID 23453219
Alternariol
One
HDAC2
3
A Potential Drug
Cbz
Small molecule inhibitor CRT0066101 inhibits cytokine storm syndrome in a mouse model of lung injury PMID 37182445
Improvement of motor nerve conduction velocity in diabetic rats requires normalization of the polyol pathway metabolites flux PMID 19212096
CCK Receptor
磷酸甘油酸激酶 1（PGK1）基因
Discovery of ML324, a JMJD2 demethylase inhibitor with demonstrated antiviral activity PMID 24260783
(24S)
A study on the anti
Targeting EFNA1 suppresses tumor progression via the cMYC
A novel role for carbon monoxide as a potent regulator of intracellular Ca2+ and nitric oxide in rat pancreatic acinar cells PMID 25252950
DB07107 552332
alkylamide
Protection against nonalcoholic steatohepatitis through targeting IL
Fangchinoline derivatives induce cell cycle arrest and apoptosis in human leukemia cell lines via suppression of the PI3K/AKT and MAPK signaling pathway PMID 31784186
3
MMP3 as a new target of Danshensu/tetramethylpyrazine derivative for attenuating cardiac fibrosis post
Leukotriene B
MS8511
MLS 000536924
Mitochondrial GCN5L1 coordinates with YME1L and MICOS to remodel mitochondrial cristae in white adipocytes and modulate obesity PMID 40338741
糖蛋白 VI 血小板（GP6）基因
S
N
XR5944 343247
GLP
The cyanobacterial oligopeptides microginins induce DNA damage in the human hepatocellular carcinoma (HepG2) cell line PMID 31542581
地塞米松
A nitric oxide
Indoloditerpenes from a marine
Direct and indirect electrochemical reduction prior to a biological treatment for dimetridazole removal PMID 28414944
A novel mechanism for the protection against acute lung injury by melatonin mitochondrial quality control of lung epithelial cells is preserved through SIRT3
Unoprostone (isopropyl unoprostone) PMID 8877315
Proinsulin C
Chronic cerebral hypoperfusion induces venous dysfunction via EPAS1 regulation in mice PMID 40628749
Ipratropium bromide potentiates bronchoconstriction induced by vagal nerve stimulation in the guinea
Trimebutine
3
Atrasentan alleviates high glucose
Osteoprogenitor
Indirubin inhibits cell proliferation, migration, invasion and angiogenesis in tumor
The histone deacetylase inhibitor PCI
MCE
Exosomes induce and reverse monocrotaline
Leucine attenuates muscle atrophy and autophagosome formation by activating PI3K/AKT/mTOR signaling pathway in rotator cuff tears PMID 31020406
FAK inhibitor 6 2410056
Harnessing Mechanical Stress with Viscoelastic Biomaterials for Periodontal Ligament Regeneration PMID 38460171
单响尾蛇毒蛋白
艾代拉里斯
Exatecan intermediate 9
Essential role for ZAP
Isotoosendanin exerts inhibition on triple
Incorporation of Privileged Structures into Bevirimat Can Improve Activity against Wild
acute myeloid leukemia
Recombinant Treponema pallidum protein Tp0136 promotes fibroblast migration by modulating MCP
?Pancreatic Cancer
CPDT 14085
Nitroimidazoles in Albanian honey samples by LC
Fatty acid transport protein
Inhibitory activity of homoisoflavonoids from Caesalpinia sappan against Beauveria bassiana PMID 12946725
MSCs
FNDC5/Irisin exacerbates APAP
Effects and mechanisms of puerarin against neuroblastoma insights from bioinformatics and in vitro experiments PMID 38982456
Quercetin
Folic acid safety and toxicity a brief review PMID 2667316
Circular RNA circBNC2 inhibits tumorigenesis by modulating ferroptosis and acts as a nanotherapeutic target in prostate cancer PMID 39856701
17β
Diltiazem hydrochloride (Standard)
Inhibition of JAK2 signaling by TG101209 enhances radiotherapy in lung cancer models PMID 21325979
cholestasis desease
3T3
Vitamin M
Identification and in vivo Efficacy Assessment of Approved Orally Bioavailable Human Host Protein
p110α
7728
The TaCEP15 peptide signaling cascade modulates primary root length and drought tolerance in wheat PMID 40901958
N
Hormone
Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells PMID 28262558
CCL28 chemokine An anchoring point bridging innate and adaptive immunity PMID 28843907
Quercetin 3,7
DUSP5 (dual
Polygonatum sibiricum polysaccharide attenuates cyclophosphamide
DNA
Anthraquinones from Cassiae semen as thrombin inhibitors in vitro and in silico studies PMID 31207449
Histone deacetylase 8 in neuroblastoma tumorigenesis PMID 19118036
Diosmetin induces apoptosis by upregulating p53 via the TGF
Aromatase inhibition modulates intrinsic properties and excitability of hippocampal CA1 pyramidal cells in the APP/PS1 mouse model of Alzheimer's disease PMID 40602590
Optimization of a Series of 2,3
Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis PMID 23913123
Salt
Defective N
Boc
LAD1 promotes malignant progression by diminishing ubiquitin
DMT
P4HA2 promotes the progression of thyroid cancer by regulating PFKP
PPAR
Ligand
Proposed Mechanism of Long
肌原性分化 1（MYOD1）基因
Hydroxytyrosol 1
Subcutaneous rotenone rat model of Parkinson's disease Dose exploration study PMID 27876560
Opiorphin 864084
LILRA4/ILT
Apafant 105219
neuron
Myristoylated alanine
CHO
Lipopolysaccharide Preparation Derived From Porphyromonas gingivalis Induces a Weaker Immuno
4
Mesenchymal stem cell transplantation alleviates Sjögren's syndrome symptoms by modulating Tim
Glucagon lowers glycemia when β
NSC
Irreversible inactivation of trypanothione reductase by unsaturated Mannich bases a divinyl ketone as key intermediate PMID 16279799
Discovery of VU6024578/BI02982816 An mGlu1 Positive Allosteric Modulator with Efficacy in Preclinical Antipsychotic and Cognition Models PMID 39665415
CD31 161374
Protective mechanisms of CA074
Molecular organization of the human cathepsin D gene PMID 2069717
Bisoctrizole 103597
FFA intervention on LO2 cells mediates SNX
Ramantamig (JNJ
The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL
LIM Kinase (LIMK)
Bispecific antibody simultaneously targeting AGR2 and PD1 mediates cytotoxic T
Discovery of Novel Histone Deacetylase 6 (HDAC6) Inhibitors with Enhanced Antitumor Immunity of Anti
4
Exenatide induces aortic vasodilation increasing hydrogen sulphide, carbon monoxide and nitric oxide production PMID 24693878
Moxonidine hydrochloride 75536
Dipeptidyl Peptidase
RNA
Restricting intracellular Salmonella proliferation by coordinating p
Triphenyl phosphate
Single
Tumor
Apigenin suppresses mouse peritoneal fibrosis by down
Hepcidin
含无名指和 CHY 锌指结构域 1（RCHY1）基因
Kaempferitrin induces apoptosis via intrinsic pathway in HeLa cells and exerts antitumor effects PMID 23211658
Magnesium sulfate 7487
MCE
Tis21 knock
Simplifying and expanding analytical capabilities for various classes of doping agents by means of direct urine injection high performance liquid chromatography high resolution/high accuracy mass spectrometry PMID 27693991
J82
Eprinomectin (Standard)
DMT
Exatecan Intermediate 2 182182
Sphingosine 1
Tropomyosin related kinase receptor
D
LIMKs
DMT
anti
hydrolyzing
Novel Stable Isotope
Contribution of IL
Platelet
MTA
库林 1（CUL1）基因
Desethyl sildenafil
TPP
Triolein
2’
Antipsychotic agent pimozide promotes reversible proliferative suppression by inducing cellular quiescence in liver cancer PMID 31322218
Carazolol hydrochloride 51997
Predominant expression of 950delCAG of IL
Antifolate
Heat shock protein 90 chaperone activity is required for hepatitis A virus replication PMID 40470959
TWEAK, a member of the TNF superfamily, is a multifunctional cytokine that binds the TweakR/Fn14 receptor PMID 12787562
Tomensides A
Brefeldin A 4
Studies on Alismatis Rhizoma. II. Anti
SNT
Variculanol 135513
Sirtuin
Picraquanines A－C, three new phenolic derivatives from the stems of Picrasma quassioides PMID 32056448
Restoring the Function of Thalamocortical Circuit Through Correcting Thalamic Kv3.2 Channelopathy Normalizes Fear Extinction Impairments in a PTSD Mouse Model PMID 38102998
Bioactive Terpenes and Their Derivatives as Potential SARS
8
Tradd
Linezolid a review of its use in the management of serious gram
arteries
S100a6 Mouse Pre
1
METTL3
The Ape
A non
Cell adhesion antagonists therapeutic potential in asthma and chronic obstructive pulmonary disease PMID 18345706
Afuresertib 1047644
Il4ra
EBOV
Characteristics of inflammation process in monocrotaline
Ki20227 aggravates apoptosis, inflammatory response, and oxidative stress after focal cerebral ischemia injury PMID 34100449
Albiflorin ameliorates neuroinflammation and exerts neuroprotective effects in Parkinson's disease models PMID 39924948
Short
ATG4C 抗体 (YA600)（ATG4C Antibody (YA600)）
Adipocyte
骨碎补提取物 (Davallia trichomanoides Blume)
Progesterone receptor isoform ratio dictates antiprogestin/progestin effects on breast cancer growth and metastases A role for NDRG1 PMID 34935137
IL2 inducible T
Aminopeptidase N inhibitor 1 596108
trans
Himbacine 6879
Carcinine 56897
TRIM56 acts through the IQGAP1
Differentiation of cultured hair follicle neural crest stem cells into functional melanocytes PMID 39170163
Dual CCNE1/PIK3CA targeting is synergistic in CCNE1
Different contributions of endothelin
S
2
CCL5 promotion of bioenergy metabolism is crucial for hippocampal synapse complex and memory formation PMID 33931731
Neurological disorders after severe pneumonia are associated with translocation of endogenous bacteria from the lung to the brain PMID 37851811
C6
Novel Insight of Posterior Capsule Opacification The Role of Lens Epithelial Cell Senescence PMID 40660668
Cardiac Fgf
Pathological effects of the mushroom toxin alpha
Co
HS56 922050
1
GDP
[Cefdinir] PMID 1479675
FBXO22 mediates the NGF/TRKA signaling pathway in bone metastases in prostate cancer PMID 37301536
Reorganization of actin cytoskeleton by the phosphoinositide metabolite glycerophosphoinositol 4
Increased IP3R
CD80 抗体 (YA1413)（CD80 Antibody (YA1413)）
Atuzabrutinib 1581714
Methyl 2
p53 抗体 (YA250)（p53 Antibody (YA250)）
WS6 Induces Adult Hippocampal Neurogenesis in Correlation to its Antidepressant Effect on the Alleviation of Depressive
Lysosomal Cu(I)/Cu(II) Dependence of Antimicrobial Ability of Oyster Hemocytes and Regulation of Phagolysosomal System PMID 37955256
RO1138452 221529
3
(S)
Potassium 1H
destrin, 肌动蛋白解聚因子（DSTN）基因
Guanfacine
Cyclization strategy leads to highly potent Bromodomain and extra
The suppression of torulene and torularhodin treatment on the growth of PC
Ranirestat 147254
Macrocycle synthesis strategy based on step
A
CMC
Molecular modes of action of cephalotaxine and homoharringtonine from the coniferous tree Cephalotaxus hainanensis in human tumor cell lines PMID 12616342
MS
蛋白 1（MACO1）基因
Proteomic and phosphoproteomic analysis of rabies pathogenesis in the clinical canine brain and identification of a kinase inhibitor as a potential repurposed antiviral agent PMID 40577348
The Antitumor Activity of IMGN529, a CD37
Kaiso 抗体 (YA2543)（Kaiso Antibody (YA2543)）
Effects of a prostaglandin DP receptor agonist, AL
The LINC00519/hsa
Paromomycin sulfate 1263
Positive inotropic effect of carcinine in the isolated perfused guinea pig heart PMID 2302959
m
Rp
F
Forecast and verification of the active compounds and latent targets of Guyuan decoction in treating frequently relapsing nephrotic syndrome based on network pharmacology PMID 36866869
Metabolic labeling and LC
Synthesis and biological evaluation of a selective N
Butyrate inhibits histone deacetylase 2 expression to alleviate liver fibrosis in biliary atresia PMID 40221650
A real
HFM1 is essential for the germ cell intercellular bridge transport in primordial follicle formation in mice PMID 39725823
Lodoxamide impurity 1
Activation of the Nrf2/HO
VO
5
(S,R,S)
Synthesis and cytotoxicity of novel ursolic acid derivatives containing an acyl piperazine moiety PMID 23124210
Alkyne
Isobavachalcone ameliorates cognitive deficits, and Aβ and tau pathologies in triple
Acute and chronic administration of the selective sigma1 receptor agonist SA4503 significantly alters the activity of midbrain dopamine neurons in rats An in vivo electrophysiological study PMID 10400891
Homogeraniol 459
核糖体蛋白 S6
Regulation and Functions of 15
NAMPT inhibitor
Testicular toxicity of dietarily or parenterally administered bisphenol A in rats and mice PMID 12804662
ANGPTL7/Angiopoietin
CARM1 promotes non
Glycocyamine
CD43 蛋白, Human (HEK293, His)
NW 1028 2749599
[Analgesic effects of miroprofen in post
Nucleus
Scrophularia
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