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Chlorzoxazone exhibits neuroprotection against Alzheimer's disease by attenuating neuroinflammation and neurodegeneration in vitro and in vivo PMID 32795892
Pharmacological modulation of Sigma
Mal
14(R),15(S)
LINEAGE Label
Gimsilumab 1648796
Delivery of mitochondria confers cardioprotection through mitochondria replenishment and metabolic compliance PMID 36805084
LEE011
Airway epithelial immunoproteasome subunit LMP7 protects against rhinovirus infection PMID 36008456
MCE
Discovery of novel 2',4'
Genomic and transcriptomic analysis of breast cancer identifies novel signatures associated with response to neoadjuvant chemotherapy PMID 38217005
Evaluation of structured lipids with behenic acid in the prevention of obesity PMID 28395825
Small molecule inhibitors of intestinal epithelial anion exchanger SLC26A3 (DRA) with a luminal, extracellular site of action PMID 36724632
Antinociceptive effects of cefadroxil and ceftriaxone in experimental animal models of pain PMID 37524320
A novel angiotensin II type 2 receptor antagonist TDI05 alleviates the peripheral neuropathic pain PMID 40885515
DOCPe
Azido
Molecular characterization of EP6
Curcumin relieves CFA
Arctigenin inhibits abnormal germinal center reactions and attenuates murine lupus by inhibiting IFN
Ketamine induces rapid antidepressant effects via the autophagy
M1
Electrochemical sensor for detecting streptomycin in milk based on label
Static magnetic fields alleviate diabetic nephropathy by reducing renal cell inflammation and promoting M2 macrophage polarization PMID 40013926
Regulatory effect and mechanism of APN gene on porcine epidemic diarrhea virus resistance PMID 33482281
杀伤细胞凝集素样受体 K1（KLRK1）基因
Alfuzosin hydrochloride 81403
Pharmacological inhibition of Receptor Protein Tyrosine Phosphatase β/ζ (PTPRZ1) modulates behavioral responses to ethanol PMID 29753117
Alvimopan metabolite
Quercetin
Pharmacological profile of ipragliflozin (ASP1941), a novel selective SGLT2 inhibitor, in vitro and in vivo PMID 22139434
Boc
1
HDAC6
Novel pyrazolo[3,4
[68Ga]pentixafor for CXCR4 imaging in a PC
(
6
APR
Histone Deacetylase 3 Inhibitor Suppresses Hepatitis C Virus Replication by Regulating Apo
Mkrn3 Rat Pre
Horse Serum Albumin (马血清白蛋白)
SETD7 regulates chondrocyte differentiation and glycolysis via the Hippo signaling pathway and HIF‑1α PMID 34617577
白细胞介素 12A（IL12A）基因
Oxaliplatin accelerates immunogenic cell death by activating the cGAS/STING/TBK1/IRF5 pathway in gastric cancer PMID 40260556
Targeting the Raf kinases in human cancer the Raf dimer dilemma PMID 29235562
Reversal of multidrug resistance of cancer through inhibition of P
Effects of Pyridostigmine bromide on SH
NiCur 2674753
Pharmacokinetics of the P
Delayed metformin treatment improves functional recovery following traumatic brain injury via central AMPK
Interleukin
Impact of brown rice
Immunotherapy in multiple myeloma PMID 34653747
Efficacy and safety of elinzanetant, a selective neurokinin
Novel Covalent Probe Selectively Targeting Glutathione Peroxidase 4 In Vivo Potential Applications in Pancreatic Cancer Therapy PMID 38265413
Nefl
GLP
BARHL2 Human Pre
Improved therapeutic efficacy of mammalian expressed
Dual targeting of HSP70 does not induce the heat shock response and synergistically reduces cell viability in muscle invasive bladder cancer PMID 30220976
(R)
Double
Aramchol downregulates stearoyl CoA
2
MELK
NAD
Nanoparticle
Runcaciguat, a novel soluble guanylate cyclase activator, shows renoprotection in hypertensive, diabetic, and metabolic preclinical models of chronic kidney disease PMID 34550407
Prostaglandin Receptor
Ribosomal RNA transcription governs splicing through ribosomal protein RPL22 PMID 39211199
DT2216 2365172
RIP1 Kinase Drives Macrophage
Chronic restraint stress disturbs meiotic resumption through APC/C
ANG1009 1220637
B 细胞受体相关蛋白 31（BCAP31）基因
Shining LIGHT on the metabolic role of the cytokine TNFSF14 and the implications on hepatic IL
Histone demethylase inhibitor KDM5
DUSP1
TNF Receptor
UV filter benzophenone
DNMT3A Cooperates with YAP/TAZ to Drive Gallbladder Cancer Metastasis PMID 38380551
Ligand
Compound shougong powder inhibits the malignant phenotype of hepatocellular carcinoma cells by targeting the DNA damage repair pathway PMID 36966364
MDM2
肌肉相关受体酪氨酸激酶（MUSK）基因
(R)
The Elegance of Sonic Hedgehog Emerging Novel Functions for a Classic Morphogen PMID 30381425
Modular self
(D
The role and mechanism of myeloperoxidase in dermatomyositis PMID 37625367
5
Roles of capsaicin
Leucine
Bisphenol
C.I. Acid blue 158
N
Therapeutic efficacy of sorafenib and plant
Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage PMID 37996529
Naringin Targets NFKB1 to Alleviate Oxygen
BRL
Anti
N1
(17R,18S)
Etrolizumab 1044758
Dual
Mirodenafil ameliorates skin fibrosis in bleomycin
exocyst 复杂组件 8（EXOC8）基因
Sigma
Stimulation of Eryptosis, the Suicidal Erythrocyte Death by Piceatannol PMID 27197738
N1,N8
Enflicoxib 251442
Maralixibat First Approval PMID 34813049
5 '
TIA1
Simplified captopril analogues as NDM
Glucosamine Cholesterol 1257309
NCT
Tomentin 28449
Ultrasound
Discovery of Oral Anticancer 1,2
Berberine inhibits intestinal epithelial barrier dysfunction in colon caused by peritoneal dialysis fluid by improving cell migration PMID 32750460
From wheal to wellness efficacy and safety of ligelizumab in chronic spontaneous urticaria a systematic review and meta
IRAK4
Methyltetrazine
微小 RNA
Synthesis and structure
Pharmacological depletion of microglia protects against alcohol
Synthesis and identification of GZD856 as an orally bioavailable Bcr
N
Differential effects of PGAM5 knockout on high fat high fructose diet and methionine choline
The biosynthesis of 6
ADC Cytotoxin
Obeticholic Acid First Global Approval PMID 27406083
Amino
WGX50 mitigates doxorubicin
Triamcinolone acetonide
Alzheimer’s disease (AD)
Discovery of fused bicyclic agonists of the orphan G
CD47 blockade inhibits tumor progression human osteosarcoma in xenograft models PMID 26093091
Altromycin F 134887
2
碱性亮氨酸拉链 ATF 样转录因子 3（BATF3）基因
Eliminating hypoxic tumor cells improves response to PARP inhibitors in homologous recombination
Estrogen receptors participate in carcinogenesis signaling pathways by directly regulating NOD
UC
Azido
Mal
PD
Engineering the surface properties of a human monoclonal antibody prevents self
Zarutatug 3038456
3’
Masp2
Fmoc
Bifemelane hydrochloride 62232
碱性亮氨酸拉链 ATF 样转录因子 2（BATF2）基因
1,2
Adrenomedullin (16
(Rac)
Tataramide B 187655
Discovery of 4
Aqueous solutions of didecyldimethylammonium chloride and octaethylene glycol monododecyl ether Toward synergistic formulations against enveloped viruses PMID 27452423
EEDi
Antitumor activity of paclitaxel and epirubicin in human breast carcinoma, R
Aberrant PLAC8 expression characterizes glioblastoma with temozolomide resistance and an immunosuppressive microenvironment PMID 40398706
GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models PMID 17327487
缺氧上调 1（HYOU1）基因
转化生长因子α（TGFA）基因
t
tert
(±)
L
Cathepsin S
AS601245 (1,3
Inhibition of Collagen Related Peptide Induced Platelet Activation and Apoptosis by Ceritinib PMID 29490295
Flurbiprofen axetil alleviates the effect of formalin
SIRT7 affects the proliferation and apoptosis of papillary thyroid cancer cells by desuccinylation of LATS1 PMID 40050771
Effect of limonin and nomilin on HIV
170082
Krüppel
Morphological profiling of human T and NK lymphocytes by high
Structural Pharmacology of TRPV4 Antagonists PMID 38659239
ZFP36 regulates the osteogenic differentiation of adipose
Longan polysaccharides promote Th1 and Treg cell differentiation via dendritic cells PMID 40749906
Sirpiglenastat 2079939
Peptide BG From Bitter Gourd (Momordica Charantia) Improves Adjuvant
Loracarbef hydrate (Standard)
Stereospecific targeting of MTH1 by (S)
Piezo1
Loss of sphingosine kinase 2 enhances Wilm's tumor suppressor gene 1 and nephrin expression in podocytes and protects from streptozotocin
Calcium channel blocker
细胞色素 P450 家族 4 亚家族 F 成员 2（CYP4F2）基因
Pharmacological Characteristics of Anxiolytics on Acetylcholine
Chiral pool synthesis of enantiomerically pure morphan derivatives with κ receptor affinity from (S)
Stress conditions induced circRNAs profile of extracellular vesicles in brain microvascular endothelial cells PMID 35699856
Structure of the DDB1
Coordinated activation of c
Blockage of SLC31A1
Chinifur (Quinifuryl)
A mitochondria
(3S)
Transcriptome analysis of key genes and pathways associated with cisplatin resistance in oral squamous cell carcinoma Cal27 cells PMID 40227535
Direct vascular actions of methyclothiazide and indapamide in aorta of spontaneously hypertensive rats PMID 11030443
Interferon
KPV and RAPA Self
hMAO
Synthesis and biological evaluation of novel benzodioxinocarbazoles (BDCZs) as potential anticancer agents PMID 20566289
Anti
Temporal dynamics of immune cell transcriptomics in brain metastasis progression influenced by gut microbiome dysbiosis PMID 40023843
LongShengZhi capsule inhibits doxorubicin
The protective role of endogenously synthesized nitric oxide in staphylococcal enterotoxin B
Darizmetinib 2369583
(R)
Leucic acid (α
MCE
DOTA
A Central Amygdala Input to the Parafascicular Nucleus Controls Comorbid Pain in Depression PMID 31851918
SAR and lead optimization of (Z)
L
Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study PMID 28397877
Keep on ROCKIn Repurposed ROCK inhibitors to boost corneal endothelial regeneration PMID 38513591
Synergistic effects of botanical curcumin
The tolerable upper intake level of manganese alleviates Parkinson
Cannabidiol reverts the malignant phenotype of hepatocellular carcinoma cells via the GPR55/TP53/MAPK axis PMID 38825256
Effects of Trigonelline, an Alkaloid Present in Coffee, on Diabetes
TSPYL1 as a Critical Regulator of TGFβ Signaling through Repression of TGFBR1 and TSPYL2 PMID 38588050
Brincidofovir (CMX001) Toxicity Associated With Epithelial Apoptosis and Crypt Drop Out in a Hematopoietic Cell Transplant Patient Challenges in Distinguishing Drug Toxicity From GVHD PMID 29846280
4
14 0
Abietane and C20
Discovery of a New and Selective HPK1 PROTAC for Enhancing Tumor Immunotherapy through Eliminating GLK Degradation PMID 40375722
Naringin induces apoptosis of gastric carcinoma cells via blocking the PI3K/AKT pathway and activating pro‑death autophagy PMID 34490484
MAO
Fc γ 受体 Ia（FCGR1A）基因
Discovery of novel indazole derivatives as dual angiotensin II antagonists and partial PPARγ agonists PMID 24462665
Targeted nanosensitizer
Ubiad1 Rat Pre
IL
Promising Non
Flavokawain A inhibits Cytochrome P450 in in vitro metabolic and inhibitory investigations PMID 27318274
磷酸酶和肌动蛋白调节因子 1（PHACTR1）基因
OPA1 Human Pre
Comparative analysis of pectic polysaccharides isolated from various thinned young red
N
Dimethyl fumarate, an immune modulator and inducer of the antioxidant response, suppresses HIV replication and macrophage
3
Na+/H+ Exchanger (NHE)
Tailoring Tumor Cell Golgi Apparatus
Troxerutin Attenuates Enhancement of Hepatic Gluconeogenesis by Inhibiting NOD Activation
Anticancer activity and SAR studies of substituted 1,4
Toll like receptor (TLR)
Determination and confirmation of metronidazole, dimetridazole, ronidazole and their metabolites in bovine muscle by LC
地塞米松
A unique small molecule inhibitor of enolase clarifies its role in fundamental biological processes PMID 23547795
(R)
ovarian
Cbz
FDA
Phenelfamycin F 114451
4
GATA1
DW14006 as a direct AMPKα1 activator improves pathology of AD model mice by regulating microglial phagocytosis and neuroinflammation PMID 32739363
Bile Acid sulfation a pathway of bile acid elimination and detoxification PMID 19131563
Benalaxyl metabolite M1
The GluN2C/D
Throughput
A novel series of highly selective inhibitors of MMP
Exosomes secreted from mesenchymal stem cells mediate the regeneration of endothelial cells treated with rapamycin by delivering pro
MCE
Natural melanin nanoparticles (MNPs) extracted from Sepia officinalis A cost
Cloxiquine 130
Trans
The diverse pancreatic tumor cell
Deficiency in the Rab25 gene leads to a decline in male fertility and testicular injury Impact on the regulation of germ cell proliferation and apoptosis PMID 39424096
Eugenol reduces acute pain in mice by modulating the glutamatergic and tumor necrosis factor alpha (TNF
E260 1241537
ABM
Targeting Glycoprotein NMB With Antibody
TCTEX1D4, a novel protein phosphatase 1 interactor connecting the phosphatase to the microtubule network PMID 23789093
Salvianolate ameliorates oxidative stress and podocyte injury through modulation of NOX4 activity in db/db mice PMID 33332718
3’
Pyrimidinylpiperdinyloxypyridone Analogues as GPR119 Modulators PMID 24900860
Chalcone derivatives from licorice inhibit human and rat gonadal 3β
PEAR1 Promotes Myoblast Proliferation Through Notch Signaling Pathway PMID 39765730
Total Synthesis of Hispidulin and the Structural Basis for Its Inhibition of Proto
Axl
GPVI antagonist 3 901654
Pomalidomide 4'
NFAT5 Amplifies Antipathogen Responses by Enhancing Chromatin Accessibility, H3K27 Demethylation, and Transcription Factor Recruitment PMID 34031145
DP
NLRP3 inflammasome blocked the glycolytic pathway via targeting to PKLR in arsenic
Bis
Tinosporol B 2244777
Double network hydrogel based on curdlan and gelatin methacryloyl (GelMA) with enhanced mechanical and tissue adhesive properties PMID 40675295
Epidermal growth factor receptor signaling is required for microadenoma formation in the mouse azoxymethane model of colonic carcinogenesis PMID 17234795
Thiamet
Metabolic collateral lethal target identification reveals MTHFD2 paralogue dependency in ovarian cancer PMID 36131208
Bromelain Alleviates Sleep Deprivation
Siglec
Effects of a new combination of plant extracts plus d
6
Elevated cyclin A associated kinase activity promotes sensitivity of metastatic human cancer cells to DNA antimetabolite drug PMID 26058363
NIT 299922
CP
Fesoterodine 286930
Butein sensitizes HeLa cells to cisplatin through the AKT and ERK/p38 MAPK pathways by targeting FoxO3a PMID 26310353
HSPA9 contributes to tumor progression and ferroptosis resistance by enhancing USP14
2,5
Shikonin Inhibits Tumor Growth of ESCC by suppressing PKM2 mediated Aerobic Glycolysis and STAT3 Phosphorylation PMID 34234853
Acid
Computationally identified novel agonists for GPRC6A PMID 29684031
(S)
Biological evaluation of 1,3
Exploring the molecular mechanisms of subarachnoid hemorrhage and potential therapeutic targets insights from bioinformatics and drug prediction PMID 40229542
Bis
Design, synthesis and biological evaluation of novel spiro
Pharmacokinetics and pharmacodynamics of once
SKI2496
NKG2A 蛋白, Human (Biotinylated, HEK293, His
Screening and identification of antimicrobial peptides from the gut microbiome of cockroach Blattella germanica PMID 39709489
Adenosine 5'
Discovery of potent, orally bioavailable ERK1/2 inhibitors with isoindolin
Isolation and characterization of concanamycins A, B and C PMID 6511660
A validated ultra
N'
N
Shh
hCAIX
Dmt
Glutaminase C
白细胞介素 18（IL18）基因
Mall Mouse Pre
P4HB 蛋白, Human (His)
anti
O 型蛋白酪氨酸磷酸酶受体（PTPRO）基因
PF
Zinc
4
MCC950 Ameliorates Diabetic Muscle Atrophy in Mice by Inhibition of Pyroptosis and Its Synergistic Effect with Aerobic Exercise PMID 38338456
Sennoside B 128
3,5
PRMT5
Actarit
Diclofenamide in the treatment of therapy
NEU4
Vitamin K1
Purine metabolism
The crucial role of metabolic regulation in differential hepatotoxicity induced by furanoids in Dioscorea bulbifera PMID 31955824
Cryo
Lesinurad 878672
Nebulization of risedronate alleviates airway obstruction and inflammation of chronic obstructive pulmonary diseases via suppressing prenylation
Xestospongins potent membrane permeable blockers of the inositol 1,4,5
MicroRNA
噬菌体
20S Proteasome
Sirtuin modulator 8 925437
Angoline 21080
Telomerase
Talfirastide 51833
Novel CDK9 inhibitor oroxylin A promotes wild
RP
The Study of Exosomes
1
Immunofluorescence
2
Bioactive Constituents from the Termite Nest
p38 MAPK regulates the Wnt inhibitor Dickkopf
Synthesis and evaluation of the antimalarial, anticancer, and caspase 3 activities of tetraoxane dimers PMID 24148834
OSW
DSG
FSC231 alleviates paclitaxel
Mal
Enhanced Porcine Reproductive and Respiratory Syndrome Virus Replication in Nsp4
Se
HIF
Protective effect of scutellarin on myocardial cells treated with high glucose PMID 40599620
MiRNA
(S)
AP
Evidence of Increased Hydrophobicity and Dynamics inside the Tail Region of Glycolipid Self
Fragment
Isoquercetin Ameliorates Osteoarthritis via Nrf2/NF
Inhibition of GLI
Optimization of a Potent, Orally Active S1P1 Agonist Containing a Quinolinone Core PMID 24900374
Empedopeptin 87551
Cancer
A natural indole alkaloid, norharmane, affects PIN expression patterns and compromises root growth in Arabidopsis thaliana PMID 32278957
Anticoagulants (thrombin inhibitors) and aspirin synergize with P2Y12 receptor antagonism in thrombosis PMID 14597584
厌氧菌琼脂
PFKFB4
ANKRD13a controls early cell
Analysis of chicken macrophage functions and gene expressions following infectious bronchitis virus M41 infection PMID 33509253
Chemical Constituents from the Stems of Morinda citrifolia Linn PMID 17703727
Apitegromab 2278276
Dihexa 1401708
MAC13243 1071638
Arachidic acid N
Lactisole 150436
Methyl citrate 26163
Activin A in Mammalian Physiology PMID 30540228
Osteopontin
(2
New small
5
t
Pachygone ovata (Poir.) Miers ex Hook.f. & Thomson提取物 (Pachygone ovata (Poir.) Miers ex Hook.f. & Thomson)
No effect of angiotensin II AT(2)
Celiprolol hydrochloride 57470
Carbon quantum dots
SGI
Discovery of the novel potent and selective FLT3 inhibitor 1
Small
Levetiracetam a novel antiepileptic drug PMID 11714211
NBI
Discovery of FNDR
Discovery and Mechanistic Characterization of Selective Inhibitors of H2S
MCE
NADPH oxidase
Transferrin receptor targeting chimeras for membrane protein degradation PMID 39322661
Antinociceptive properties of propofol involvement of spinal cord gamma
Enhancing the aqueous solubility of d4T
Exploiting PRMT5 as a target for combination therapy in mantle cell lymphoma characterized by frequent ATM and TP53 mutations PMID 36797243
AChE
THP
Obacunone regulates ferroptosis in ovarian cancer through the Akt/p53 pathway PMID 39708098
Mca
NerveGreen C3 1331918
Prednisolone F
6′′
Single Cell RNA Sequencing Identifies a Unique Inflammatory Macrophage Subset as a Druggable Target for Alleviating Acute Kidney Injury PMID 35112806
ST1926 inhibits glioma progression through regulating mitochondrial complex II PMID 32526455
Methylation of BRD4 by PRMT1 regulates BRD4 phosphorylation and promotes ovarian cancer invasion PMID 37737256
A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning PMID 19906975
Comparison of cyclooxygenase
1,2,3,4,8,9
Effect of [dl]
N4
减数分裂核分裂 5 同系物 A 所需（RMND5A）基因
Liproxstatin
m
Antidiabetic compounds from Sarracenia purpurea used traditionally by the Eeyou Istchee Cree First Nation PMID 22738356
3
The kinesin
Sodium (S)
Disulfide
G
EP300
Myeloid
Synthesis, preclinical evaluation, and a pilot clinical imaging study of [18F]AlF
Ischemic Stroke Increased Gadolinium Deposition in the Brain and Aggravated Astrocyte Injury After Gadolinium
Palmitic acid
Purification and kinetic characterization of human indoleamine 2,3
Two new compounds from the roots of Paeonia lactiflora Pall. and their anti
Effect of Heparan Sulfate on Vasculogenesis and Dentinogenesis of Dental Pulp Stem Cells PMID 38719089
Inhibition of the NLRP3/caspase
SB
S1647 259528
SGC
Citric acid tripotassium hydrate 6100
[Sodium tanshinone IIA sulfonate prevents postoperative peritoneal adhesions in rats by enhancing the activity of the peritoneal fibrinolytic system] PMID 26922027
The NR2B
Durvalumab an investigational anti
Ibuprofen carboxylic acid
Glucose
NG
Mechanical stretching of the pulmonary vein mediates pulmonary hypertension due to left heart disease by regulating SAC/MAPK pathway and the expression of IL
Asparanin A from Asparagus officinalis L. Induces G0/G1 Cell Cycle Arrest and Apoptosis in Human Endometrial Carcinoma Ishikawa Cells via Mitochondrial and PI3K/AKT Signaling Pathways PMID 31861958
The molecular basis for inhibition of sulindac and its metabolites towards human aldose reductase PMID 22155003
A highly selective, high
Carazolol
(4S)
2
Circular RNA profiling reveals an abundant circPTK2 that contributes everolimus
(Rac)
Prostaglandin E2 alleviates inflammatory response and lung injury through EP4/cAMP/IKK/NF
Inhibitory activity of a ceramide library on interleukin
Novel 1,2,4
VIP and endothelin receptor antagonist an effective combination against experimental pulmonary arterial hypertension PMID 22029879
Characterization of the inhibitory activity of natural tanshinones from Salvia miltiorrhiza roots on protein tyrosine phosphatase 1B PMID 29031618
2'
Synthesis and antimycobacterial evaluation of newer 1
HSK3486
JDTic dihydrochloride 785835
IL
Targeted tumor cell
最小溶血浓度
One
S
BET
Association of immunosuppressive CD45+CD33+CD14
Imneskibart 2919583
Methyllycaconitine prevents methamphetamine
A dRASSF
BIRB796, the inhibitor of p38 mitogen
Embryonic stem cell microenvironment suppresses the malignancy of cutaneous melanoma cells by down
Stemregenin 1 hydrochloride 2319882
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