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A distinct transcriptome characterizes neural crest
In
Neuroprotective Effects of Tetrahydroxystilbene Glucoside against Rotenone
O
BMI1
JAK2 inhibition mediates clonal selection of RAS pathway mutations in myeloproliferative neoplasms PMID 40623967
(2S,3R)
Targeting MAN1B1 potently enhances bladder cancer antitumor immunity via deglycosylation of CD47 PMID 40493414
Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action PMID 17954919
MCE
Eicosapentaenoic acid ethyl ester 86227
MCE
Hypoxic training upregulates mitochondrial turnover and angiogenesis of skeletal muscle in mice PMID 33716067
Antitumor agent
β2
7
Differentiation
Upregulation of IDO gene expression reduces the immunogenicity of epidermal cells and strengthens the immune protection of epidermal cells during transplantation treatment of wounds PMID 38218230
Tle3 Mouse Pre
Lumbrokinase (LK) ameliorates diabetic kidney disease renal fibrosis through regulating snail via m6A RNA methyltransferase 3 PMID 39562622
ROCK2
Melatonin Receptor
Macrophage
MCE
Fandosentan potassium 221246
EUK118
CEP
combined salt
AN11251 2130750
Anti
PKM2
Slc1a1 Mouse Pre
MeTC
Zanoterone (WIN 49596)
?Eimeria meleagrimitis
MCE
KOR agonist 7
CEACAM1 抗体 (YA3496)（CEACAM1 Antibody (YA3496)）
MCE
APCDD1L Human Pre
RHEB 蛋白, Human (sf9, N
Piperkadsin A
MCE
Investigation of Adsorption Tyrphostin AG528 Anticancer Drug Upon the CNT(6,6
Ganciclovir sodium 107910
Lorlatinib 1454846
rel
Stepwise phosphorylation and SUMOylation of PIDD1 drive PIDDosome assembly in response to DNA repair failure PMID 39448602
Sandacanol 28219
MZ
Serratiopeptidase 37312
Ultrasound
20
Ebola virus Glycoprotein/GP 蛋白 (AHX24649, HEK293, His)
Human FGF5 mRNA
Apostatin
Arf6
A new series of small molecular weight compounds induce read through of all three types of nonsense mutations in the ATM gene PMID 23774824
MCE
Blonanserin ameliorates social deficit through dopamine
AM
ARV1 同系物，脂肪酸稳态调节因子（ARV1）基因
Oudenone derivative
tripyridylamide
DU6859a
tert
Adenosine
MCE
Synergistic effect of formoterol and mometasone in a mouse model of allergic lung inflammation PMID 17618304
RET 蛋白, Mouse (HEK293, His)
BMS
Rhodamine B hydrazide 74317
FRAX597 1286739
A Simple Proton
Pulmonary Toxicity of Benzalkonium Chloride PMID 28683210
Rosaprostol
Adagrasib 2326521
VI 型胶原蛋白 alpha 1 链（COL6A1）基因
TENM4 Human Pre
2,4
Fibronectin 1 inhibits the apoptosis of human trophoblasts by activating the PI3K/Akt signaling pathway PMID 33000176
弥漫性泛细支气管炎
Lomefloxacin PMID 28431777
cd3d
Lgr5 Rat Pre
聚氧乙烯脂肪醇醚S10
MCE
Thallium
intracerebral hemorrhage
MCE
Cdkal1
Evaluation of DNA damage in Wistar rat tissues with hyperlipidemia induced by tyloxapol PMID 28684216
Acid
infection diseases
CC 基序趋化因子配体 1（CCL1）基因
UMB24 1033
Cefoxitin sodium 33564
OCRL 肌醇多磷酸 5 磷酸酶（OCRL）基因
Potent inhibition of human and rat 17β
Crenolanib 670220
Azido Palmitic Acid
Capsaicin induces mitochondrial dysfunction and apoptosis in anaplastic thyroid carcinoma cells via TRPV1
锥虫感染 (Trypanosome Infection)
Nedisertib (Peposertib)
SELPLG Human Pre
L
TGFβ1 accelerated the progression of diabetic nephropathy via up
Fmoc
MCE
西维来司他 (标准品)
MCE
Neuroprotectin D1 methyl ester 934005
Bromoflavone
BRX 220
eHSPTACs
MCE
Δ8
DOSPA (hydrochlorid)
Tnfsf8 Rat Pre
Experimental long
PBI
5β,6β
Pharmacological inhibition of PSPH reduces serine levels and epileptic seizures PMID 40456963
Rabeprazole sodium 117976
Rgs16 Mouse Pre
Valsartan ameliorates ageing
LEGO
SL
PAA5
Role for ERK1/2
Elimination of melanoma by sortase A
Discovery of a Highly Potent and Selective MEK Inhibitor GSK1120212 (JTP
Suppressive effect of an orally active MEK1/2 inhibitor in two different animal models for rheumatoid arthritis a comparison with leflunomide PMID 22245957
FGF9 promotes mouse spermatogonial stem cell proliferation mediated by p38 MAPK signalling PMID 33107118
Platelet
Icos Rat Pre
HN1 蛋白, Mouse (His)
Cy5
Tyrphostin 63 5553
Ex vivo model of non
Photoregulin1 1003736
Tetrahydrofolic acid
Prostaglandin E2 p
p53
Albocycline K3 178114
MCE
N
C1q Protein (rabbit)
Novel PROTAC probes targeting KDM3 degradation to eliminate colorectal cancer stem cells through inhibition of Wnt/β
APCDD1 Human Pre
N
(
FR194738 204067
Network Pharmacology Followed by Experimental Validation to Explore the Mechanism of Stigmasterol in Sangbaipi Decoction Regulating PI3K/Akt Signaling to Alleviate Acute Exacerbation of Chronic Obstructive Pulmonary Disease PMID 39140079
Rational Design and Synthesis of Highly Stable Haloflavanone DNA Methyltransferase Inhibitors Inducing Tumor Suppressor Gene Re
已炔二醇
SKF1 678997
Impact of novel NS5A resistance
CHRFAM7A Overexpression Attenuates Cerebral Ischemia
Protective effect of rutin on ferroptosis
Identification of ZDHHC17 as a Potential Drug Target for Swine Acute Diarrhea Syndrome Coronavirus Infection PMID 34700373
Improving the circulation time and renal therapeutic potency of extracellular vesicles using an endogenous ligand binding strategy PMID 36375619
GLP
Neurorescuing effect of Cinacalcet against hypercalcemia
Sargassum fusiforme Fucoidan Ameliorates Obesity
PD
Design, synthesis, evaluation and optimization of potent IRAK4 inhibitors alleviating production of inflammatory cytokines in LPS
Mgp100
SRC
Delivery of a BET protein degrader via a CEACAM6
ACE2/Ang(1
L
Antiepileptic effects of two Rho
tert
Monocarboxylate Transporter 4 Inhibition Reduces Synovial Hyperproliferation and Metabolic Reprogramming Under Hypoxia in Rheumatoid Arthritis PMID 40829205
Impairing the interaction between Erg11 and cytochrome P450 reductase Ncp1 enhances azoles' antifungal activities PMID 40707518
Lesopitron 132449
(+)
MicroSphere 3D Structures Delay Tissue Senescence through Mechanotransduction PMID 39787443
HDAC inhibition protects RPE cells from oxidative stress via enhanced mitochondrial fusion, cytoskeletal repair, and Nrf
Gdnf
Triple Combination of MEK, BET, and CDK Inhibitors Significantly Reduces Human Malignant Peripheral Nerve Sheath Tumors in Mouse Models PMID 39786423
The addition of abemaciclib to sunitinib induces regression of renal cell carcinoma xenograft tumors PMID 29221116
E
mTOR inhibitor
Succinic acid
TNFSF8 Human Pre
Maiwei Yangfei decoction protects against pulmonary fibrosis by suppressing NLRP3 inflammasome
Conditioned Medium Derived From Human Dental Follicle Mesenchymal Stem Cells Alleviates Macrophage Proinflammatory Responses Through MAPK
Mitochondrial transplantation rescues Ca2+ homeostasis imbalance and myocardial hypertrophy in SLC25A3
Zn
The role of Atp2a2
Roseburia intestinalis
HECTD3 E3 ligase mediates ubiquitination of AKT
溶质载体家族 11 成员 2（SLC11A2）基因
YTP
AZ'6421
AKT2/mTOR/VEGF Signaling Attenuates Aging
Ningnanmycin
α
Self
DC
Myrianthic acid
Targeting BCL2 with Venetoclax Enhances the Efficacy of the KRASG12D Inhibitor MRTX1133 in Pancreatic Cancer PMID 39137400
Metformin counteracts stimulatory effects induced by insulin in primary breast cancer cells PMID 35672854
Reprogramming of bivalent chromatin states in NRAS mutant melanoma suggests PRC2 inhibition as a therapeutic strategy PMID 34289358
BTLA
Nanozyme
Blocking the ADAM9/ITGAV Pathway Ameliorates Sepsis
Aldosterone induces renal lymphangiogenesis through macrophage
PARP14 inhibitor H10
Cell adhesion molecule 4 suppresses cell growth and metastasis by inhibiting the Akt signaling pathway in non
Mechanism of the KIAA1429/KLF1/PD
Mezagitamab 2227490
The metabolism of the 5HT3 antagonists ondansetron, alosetron and GR87442 I a comparison of in vitro and in vivo metabolism and in vitro enzyme kinetics in rat, dog and human hepatocytes, microsomes and recombinant human enzymes PMID 17701832
Homotherapy for heteropathy therapeutic effect of Butein in NLRP3
RTA 408 ameliorates diabetic cardiomyopathy by activating Nrf2 to regulate mitochondrial fission and fusion and inhibiting NF
Drug
GSK 2793660
MCE
Unphosphorylated STAT1 binds to the BST2 transcription promoter, promoting increased AKBA anchoring on HPMECs to alleviate ARDS PMID 40307322
Mitochondrial fatty acid oxidation as the target for blocking therapy
6
RRD251
Hexokinase 2
A frog peptide provides new strategies for the intervention against skin wound healing PMID 37501100
Activation of IRF2 signaling networks facilitates podocyte pyroptosis in lupus nephritis PMID 40684959
Measurement of intracellular magnesium concentration in 3T3 fibroblasts with the fluorescent indicator Mag
PBK overexpression promotes metastasis of hepatocellular carcinoma via activating ETV4
MVP
Trehalose Prevents IL
MyD88 deficiency ameliorates weight loss caused by intestinal oxidative injury in an autophagy
Steviolbioside 41093
Infection with novel duck reovirus induces stress granule and methylation
Y
FUS Selectively Facilitates circRNAs Packing into Small Extracellular Vesicles within Hypoxia Neuron PMID 38924471
LGALS3BP/90K suppresses porcine reproductive and respiratory syndrome virus replication by enhancing GP3 degradation and stimulating innate immunity PMID 40542445
BTK
MCE
Inhibition of XIST restrains paclitaxel resistance in breast cancer cells by targeting hsa
AP
WM 3835
N
Diclofenac 15307
Radiation
Hyperactivation of MAPK Induces Tamoxifen Resistance in SPRED2
CP601932
GM
Synthesis of novel 17
MedChemExpress compounds prevent neuraminidase N1 via physics
Acotiamide first global approval PMID 23881665
Borreria and Spermacoce species (Rubiaceae) A review of their ethnomedicinal properties, chemical constituents, and biological activities PMID 22654404
Orthocaine
Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays PMID 21115097
DAPI 47165
Porgaviximab 1792982
Anticonvulsant activity of 2,4(1H)
Randomized Controlled Trial of Difelikefalin for Chronic Pruritus in Hemodialysis Patients PMID 32405581
Valerylcarnitine 40225
TNF
Dauricine alleviated secondary brain injury after intracerebral hemorrhage by upregulating GPX4 expression and inhibiting ferroptosis of nerve cells PMID 34469757
adhesion
Tanshinone IIA inhibits cervix carcinoma stem cells migration and invasion via inhibiting YAP transcriptional activity PMID 29909343
喷他脒二甲磺酸盐
analgesic effects
Phylloquinone (Vitamin K1) Occurrence, Biosynthesis and Functions PMID 27337968
AARS1
核受体亚家族 1 ，H 组，成员 4（Nr1h4）基因
Fluorinated N,N
Macrocyclic dihydropyridine analogs as pan
LncRNA PVT1 induces mitochondrial dysfunction of podocytes via TRIM56 in diabetic kidney disease PMID 39349450
Activin A protects against lipopolysaccharide/TNF
Overexpressed integrin alpha 2 inhibits the activation of the transforming growth factor β pathway in pancreatic cancer via the TFCP2
XON9
核转录因子 Y 亚基γ（NFYC）基因
Propantheline
TROP
The global phosphorylation landscape of mouse oocytes during meiotic maturation PMID 39256562
ischemic stroke
(Rac)
Methyl myristate
Synthesis and antitrypanosomal evaluation of derivatives of N
LncRNA NONHSAT227443.1 Confers Esophageal Squamous Cell Carcinoma Chemotherapy Resistance by Activating PI3K/AKT Signaling via Targeting MRTFB PMID 39150441
The PLEKHA1
Knockout of B2M in combination with PD
CD1D
Royal Jelly Induces Thin Hair Shaft Formation by Suppressing Proliferation of Hair Follicle Stem Cells in Mice PMID 40352556
FOXA1
Site
SiR
Anticonvulsant potential of rosuvastatin in combination with carbamazepine and valproate in animal models of epilepsy PMID 40548212
ALDH2 Ameliorates Acute Gouty Arthritis Through Inhibiting NLRP3 Inflammasome and Pyroptosis by Nrf2/ROS Pathway PMID 40831518
A novel CDK4 inhibitor for myeloid protection in chemotherapy
HIPK2 attenuates bleomycin
NNRT
Glutamic
The immunotoxin targeting PRLR increases tamoxifen sensitivity and enhances the efficacy of chemotherapy in breast cancer PMID 38898487
Development of coumarine derivatives as potent anti
Ligands for Target Protein for PROTAC
Lignoceric acid 557
(
MCE
FGF1 alleviates polystyrene nanoplastics
安巴洛他定
C18(Plasm) MG
Nobiletin alleviates hypoxia
1
4
Kv3 modulator 3 1498186
Posttraumatic stress disorder
Nicotinonitrile
Finasteride 98319
Obesity promotes breast epithelium DNA damage in women carrying a germline mutation in BRCA1 or BRCA2 PMID 36812344
p8 丝状噬菌体展示法
androgen
Myocardial ischemia
Rationally designed TNF
REGULATION OF BACTERIAL ENZYME SYNTHESIS BY INDUCTION AND REPRESSION PMID 14213666
Marein Alleviates Doxorubicin
Minichromosome maintenance proteins in lung adenocarcinoma clinical significance and therapeutic targets PMID 37517032
(11S)
Mudskipper β
Gadolinium
Nab
Crosstalk between YAP
Norepinephrine alkaloids as antiplasmodial agents Synthesis of syncarpamide and insight into the structure
(Z)
BC1485
2,3
Enhanced pharmacokinetic approach for anastrozole via macromolecule
3’
Pemetrexed ameliorates Con A
Unasnemab 2379805
Engineering Gene and Protein Switches for Regulation of Lineage
IL
A novel cyclohexene derivative, ethyl (6R)
Canagliflozin protects against sepsis capillary leak syndrome by activating endothelial α1AMPK PMID 34211080
Therapeutic potentials of superoxide dismutase PMID 29896077
Desvenlafaxine 93413
PCI 29732 330786
Selective inhibitors of the FK506
2,4
辣根过氧化物酶
内毒素
p38 Signaling Mediates Naringin
Transcription
Tumor
AXT107
torsin 1A 相互作用蛋白 2（TOR1AIP2）基因
Gq activity
EDI048 2767264
Structure and transport mechanism of the human prostaglandin transporter SLCO2A1 PMID 40885756
Viroxime 63198
Lichenase, Microorganism 37288
IL
Non
Dipalmitoylphosphatidylethanolamine
Overexpression of legumain in tumors is significant for invasion/metastasis and a candidate enzymatic target for prodrug therapy PMID 12782603
S2160 54799
Carbomethoxycarbonyl
Characterization of the metabolites of H3B
Pixantrone 144675
Association of tumour mutational burden with outcomes in patients with advanced solid tumours treated with pembrolizumab prospective biomarker analysis of the multicohort, open
PD
Antimelanogenic effect of 4
IRS2 抗体 (YA2271)（IRS2 Antibody (YA2271)）
TAN
Bacillus
Succinate calcium 140
GPSVFPLAPSSK
MCE
Diazobenzenesulfonic acid 2154
TRP Channel Inhibitor
MCE
MCE
Ereg Rat Pre
oral effectiveness
12
生长分化因子 2（GDF2）基因
ZD 9379 sodium
2
肌肽二肽酶 2（CNDP2）基因
MIPS
Ba/F3.p185<sup>Y253H</sup>
Emtricitabine triphosphate 145819
Carnosol alleviates sevoflurane
Chimeric HLA
BDM88951 2790420
Pharmaceutical grade synthetic peptide Thr
晶状体纤维的主要内在蛋白（MIP）基因
Generation of human ILC3 from allogeneic and autologous CD34+ hematopoietic progenitors toward adoptive transfer PMID 38149947
L 655240
MAT2A
Phosphatidylinositol bis
Cd276 Mouse Pre
TIMP
Stimulation by exosomes from hypoxia
Dabigatran 211914
EpCAM/TROP1 蛋白, Human (HEK293, Fc)
Small Molecule Activation of NAPE
Aminoacylase (Acylase I，氨基酰化酶)
Eea1 Rat Pre
翁丹色创
Multiple repair pathways mediate cellular tolerance to resveratrol
TDPAM02 2231101
TBK1
MCE
Phase II Study of Ensituximab, a Novel Chimeric Monoclonal Antibody, in Adults with Unresectable, Metastatic Colorectal Cancer PMID 32303539
Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer PMID 32183949
Clonorchis sinensis Promotes Intrahepatic Cholangiocarcinoma Progression by Activating FASN
Phospho
Alpha
Oxcarbazepine (GP 47680，奥卡西平)
Vasopressin release from the rat hypothalamo
IL
Cathepsin K inhibitor 6 325775
A novel mechanism in driving non
甘油激酶
Phb1
SeGalNac 1365541
CBiPES 353235
MCE
Oleoyl coenzyme A sodium (Oleoyl
ZNF423 Human Pre
Targeting SOX4/PCK2 signaling suppresses neuroendocrine trans
Camptothecin's journey from discovery to WHO Essential Medicine Fifty years of promise PMID 34175539
protector
Gentianose
Nitidine chloride induces cardiac hypertrophy in mice by targeting autophagy
赖氨酸 (K) 特异性脱甲基酶 1A（Kdm1a）基因
CHIR
glucosedependent insulinotropic polypeptide receptor (GIPR)
Binding of the anticancer drug BI
[68Ga]Ga
MCE
α
(R)
GSK
HPV
N
SCH
LJ001
KY19382 (A3051)
Tao
Benzomalvin A ((
3'
IMB
N
N
Phosphorylation of USP27X by GSK3β maintains the stability and oncogenic functions of CBX2 PMID 38030604
Phenosulfazole 515
(S)
Il18r1
TLR3 mediates central sensitization in a chronic migraine model induced by repeated nitroglycerin through the ERK signaling pathway PMID 40407181
Tnfsf8 Mouse Pre
Invertase, baker's yeast (S. cerevisiae), glucose/fructose/sucrose free
Dosimetry for lung tumorigenesis induced by urethane, 4
(S)
BSJ
KL001 309928
P388
ATTO 488 azide 1976022
Methyl acetate
Lei
MCE
LGR5 Human Pre
肝损伤 (Liver Injury)
PD 172760 200195
Cell labeling and tracking method without distorted signals by phagocytosis of macrophages PMID 24578725
含锌指 FYVE 型 16（ZFYVE16）基因
NEPP11
AR
siRNA nanoparticle targeting Usp20 lowers lipid levels and ameliorates metabolic syndrome in mice PMID 39173829
interneurones
MCE
Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling PMID 23063522
Mitochondrial reactive oxygen species promote cancer metastasis and tumor microenvironment immunosuppression through gasdermin D PMID 40324993
Gomisin O 72960
Targeting c
IFI16 is an innate immune sensor for intracellular DNA PMID 20890285
Synthesis, biological evaluation and molecular modeling study of some new methoxylated 2
Retinoic acid
Crotonaldehyde 2,4
Acridine Orange hydrochloride (solution)
Bacteria reduce flagellin synthesis to evade microglia
MCE
木霉醇
MCE
Anti
ISR activator 3
p53
PER1 Human Pre
NMB
Butin regulates the NLRP3/CASP
Talopeptin
JMX0254
MUM1 抗体 (YA5612)（MUM1 Antibody (YA5612)）
A novel leucine
syntaxin 17（STX17）基因
Antileukemia activity of the novel peptidic CXCR4 antagonist LY2510924 as monotherapy and in combination with chemotherapy PMID 26031918
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