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Therapeutic Potential of Fulvic Acid in Chronic Inflammatory Diseases and Diabetes PMID 30276216
First discovery of a potential carbonate prodrug of NNRTI drug candidate RDEA427 with submicromolar inhibitory activity against HIV
Anti
Guinea pig lung tryptase. Localisation to mast cells and characterisation of the partially purified enzyme PMID 8694858
Binding of dexetimide and levetimide to [3H](+)pentazocine
APLN/Apelin 蛋白, Human (HEK293, Fc)
Design, Synthesis, and Biological Evaluation of New Peripheral 5HT2A Antagonists for Nonalcoholic Fatty Liver Disease PMID 32285676
8
Discovery of MK
Structural insights for selective disruption of Beclin 1 binding to Bcl
Geraniol enhances inhibitory inputs to the paraventricular thalamic nucleus and induces sedation in mice PMID 35144136
蛋白磷酸酶 1 调节抑制因子亚基 14B（PPP1R14B）基因
Urodilatin binds to and activates renal receptors for atrial natriuretic peptide PMID 8384600
High Fat Activates O
AhyI
From Hit to Lead Structure
Dihydralazine sulfate (Standard) (硫酸双肼屈嗪 (标准品))
G 蛋白信号调节器 3（RGS3）基因
Identification of the cockroach neuropeptide Pea
(Rac)
Assembly of Model Membrane Nanodiscs for Native Mass Spectrometry PMID 33797873
GPR34 agonist 1
STING agonist
Tasquinimod Is an Allosteric Modulator of HDAC4 survival signaling within the compromised cancer microenvironment PMID 23149916
SEC61A 抗体 (YA6762)（SEC61A Antibody (YA6762)）
Antinociceptive effect of flavonol and a few structurally related dimethoxy flavonols in mice PMID 30850920
Autologous decellularized extracellular matrix protects against H2O2
Application of the dipeptidyl peptidase IV (DPPIV/CD26) based prodrug approach to different amine
Desmodium styracifolium (Osb.) Merr. Extracts alleviate cholestatic liver disease by FXR pathway PMID 39454708
Ece2
Ethyl nonadecanoate
PC Human Pre
Epopromycin A
Boc
Discovery of 2 H
RTQLLWTPAAPTAMA TFA
GRP20–29, frog
F13b Rat Pre
New nitrogen containing substituents at the indole
睡眠
DDX3
Acetylcholinesterase inhibitory activity of scopolin and scopoletin discovered by virtual screening of natural products PMID 15566295
Propargyl
Effect of Usnic Acid on Osteoclastogenic Activity PMID 30322046
Neuroprotection by crocetin in a hemi
Ret 抗体 (YA097)（Ret Antibody (YA097)）
NHS
Biogenic Amine Levels Markedly Increase in the Aqueous Humor of Individuals with Controlled Type 2 Diabetes PMID 36361545
Ferulic acid methyl ester (Standard) (阿魏酸甲酯 (标准品))
Systematic evaluation of benchmark G4 probes and G4 clinical drugs using three biophysical methods A guideline to evaluate rapidly G4
CCKBR agonist
Articaine in functional NLC show improved anesthesia and anti
Scopolin isolated from Erycibe obtusifolia Benth stems suppresses adjuvant
Inhibitory effect of glutathione S
Recombinant B
6
CRBN ligand
Direct brown 95
SYSMEHFRWGKPS
The glutaminase inhibitor telaglenastat enhances the antitumor activity of signal transduction inhibitors everolimus and cabozantinib in models of renal cell carcinoma PMID 34731180
RAFKBP12
ZD
TP
Selective, tight
Small
Mechanism of the antimicrobial action of pyrithione effects on membrane transport, ATP levels, and protein synthesis PMID 28693
Effects of thrombin receptor activating peptide on phosphoinositide hydrolysis and protein kinase C activation in cultured rat aortic smooth muscle cells evidence for tethered
The pH
LIM 同源框 9（LHX9）基因
EPHA7 Human Pre
The cytoskeleton dynamics
DL
Mtch1
trans
Ghrelin receptor full agonist
Brap
CRBN ligand
2,3
CRBN ligand
Preclinical evaluation of novel glutamate
Aurantiamide benzoate 150881
Cytochalasin D acts as an inhibitor of the actin
NSC 228155 113104
CRBN ligand
Design and Synthesis of Novel Pyridine
MOR agonist
SSA antigenic peptide
CRBN ligand
DLG
CRBN ligand
ALK
LDL 受体相关蛋白相关蛋白 1（LRPAP1）基因
Isolation and identification of phenolic compounds from Gynura divaricata leaves PMID 21716618
Bcl
Mip
Tanshinone IIA sulfonate sodium 69659
Serpinf2 Rat Pre
PS
MCE
肌球蛋白结合蛋白 H（MYBPH）基因
IHVR
15
Digoxigenin 1672
CRBN ligand
CRBN ligand
Untargeted Metabolomics Reveals Molecular Effects of Ketogenic Diet on Healthy and Tumor Xenograft Mouse Models PMID 31398922
Social cognition in attention
Structural basis for the improved drug resistance profile of new generation benzophenone non
Cd248 Rat Pre
In Vivo Knockdown of Pathogenic Proteins via S pecific and N ongenetic I nhibitor of Apoptosis Protein (IAP)
NocII TFA
PROTAC DNPH1 Degrader 1
1,3
1
Interaction of mitochondrial fission factor with dynamin related protein 1 governs physiological mitochondrial function in vivo PMID 30232469
Ultrafast, Ultrasensitive Detection and Imaging of Single Cardiac Troponin
细胞衰老 (Cellular Senescence)
Ubiquitin Conjugating Enzyme E2 I
5
CRBN ligand
EGFR
Glycyl
磷脂糖 6（GPC6）基因
Tandutinib hydrochloride 2438900
CRBN ligand
Exploiting the mitochondrial unfolded protein response for cancer therapy in mice and human cells PMID 21364280
Boc
Smarcd3 Rat Pre
Elaidyl methane sulfonate 59101
Huperzine A attenuates cognitive dysfunction and neuronal degeneration caused by beta
Targeting the CSF
Boc
CGP 20712 137888
CRBN ligand
UBP141
TK2
MCE
Fev Mouse Pre
F
Long
The synergy of BET inhibitors with aurora A kinase inhibitors in MYCN
(+)
Glycoside H2 73529
Cyclopropanecarboxyl
(S)
NC
S
Novel Alkynylamide
Guavinoside B
Epor
Milbemycin A4 51596
S
S
Tk2
YTHDC1
The Axl/Gas6 pathway is required for optimal cytokine signaling during human natural killer cell development PMID 18840707
NCL Human Pre
TXA707
Glutaminase 抗体 (YA6288)（Glutaminase Antibody (YA6288)）
Fmoc
CRBN ligand
MCE
RCL1 Human Pre
Elevation of glucose
Naproxen sodium 26159
多巴胺受体 D5（Drd5）基因
Simaravibart (MAD
SKLB
A metabolomics
COX
Penetratin
Tacrine hydrochloride 1684
(R)
CRBN ligand
CP
Sitagliptin 486460
MS 2 96552
Wheat germ oil 68917
Effects of a thiazide diuretic (hydroflumethiazide) and a loop diuretic (bumetanide) on the endocrine pancreas studies in vitro PMID 2862565
Amino
3
Design and synthesis of boronic acid inhibitors of endothelial lipase PMID 22225633
The metabolite BH4 controls T cell proliferation in autoimmunity and cancer PMID 30405245
CRBN ligand
Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway PMID 26087165
Mechanism underlying methyl eugenol attenuation of intestinal ischemia/reperfusion injury PMID 28651060
Mabuterol hydrochloride 54240
JNJ
Ncl Rat Pre
CRBN ligand
Quassinoid inhibition of AP
Continentalic acid from Aralia continentalis shows activity against methicillin
Mammalian cytidine 5'
Anti
Acebutolol impurity 2 28197
Dibenzosuberol 1210
The anti
Cyclo(
Apolipoprotein E 抗体 (YA6477)（Apolipoprotein E Antibody (YA6477)）
(1R,5Z)
Rxrs and their partner receptor genes inducing masculinization plausibly mediated by endocrine disruption in Paralichthys olivaceus PMID 36356854
Ube3c Rat Pre
Tumor
Inhibition of Staphylococcus aureus PriA Helicase by Flavonol Kaempferol PMID 25894858
Total syntheses of amythiamicins A, B and C PMID 18535690
Unoprostone 120373
Peonidin
Synthesis of quinazoline derivatives and their in vitro inhibition activity against MDA
DBCO
FGL1 抗体 (YA4211)（FGL1 Antibody (YA4211)）
USP25 蛋白, Human (His)
Biotin
Properties of rat liver microsomal stearoyl
CRBN ligand
N
4'
High
SB 258741
MCE
Cardiac autophagy is a maladaptive response to hemodynamic stress PMID 17607355
CRBN ligand
FPTQ (Standard)
Axl 抗体 (YA3944)（Axl Antibody (YA3944)）
parathion
Celaphanol A 244204
Rcl1 Rat Pre
8331
Urease
20β
copper
Substance P (7
CNKSR2 Human Pre
Factor IX 抗体 (YA1353)（Factor IX Antibody (YA1353)）
Bromoacetyl
BMS
Dermaseptin
CRBN ligand
PSTi8
The fragile X syndrome d(CGG)n nucleotide repeats form a stable tetrahelical structure PMID 8197163
Trilaciclib hydrochloride 1977495
Sandosaponin A 135272
Human cardiac stem cells rejuvenated by modulating autophagy with MHY
CRBN ligand
Itga4 Rat Pre
trans
Antiviral agent 45
MCE
Disposition of L
Inhibitory effects against α
Antennapedia Peptide, amide (Penetratin amide)
Antiviral agent 36
(S,R,S)
15(S)
NVP
Pravastatin lactone
Cloning of Glucuronokinase from Arabidopsis thaliana, the last missing enzyme of the myo
Enbezotinib (enantiomer) (TPX
Onitisin 53823
(S,S)
Discovery of SMP
CRBN ligand
The WD repeat
Antitumor studies
GLP
GPX4
Propargyl
A1CF Human Pre
TP
EP3
Cullin 2 抗体 (YA2202)（Cullin 2 Antibody (YA2202)）
Substance P, Free Acid
Choline
Immunosuppressive compounds from a deep water marine sponge, Agelas flabelliformis PMID 2530314
Surface modification of droplet polymeric microfluidic devices for the stable and continuous generation of aqueous droplets PMID 21608975
Management of primary sclerosing cholangitis and its complications an algorithmic approach PMID 33377990
Griselinoside
CRBN ligand
Chronic ISG15 Exposure Accelerates CD8+ T
Expression of activin/inhibin receptor and binding protein genes and regulation of activin/inhibin peptide secretion in human adrenocortical cells PMID 12213882
Design, synthesis, and structure
Comparison of the effects of ularitide acetate and other bronchorelaxing substances on the thrombin
Gastroprotective and antioxidant effects of usnic acid on indomethacin
Crocetin promotes clearance of amyloid
Synthesis and preclinical testing of a selective beta
DC
The preclinical assessment of XL388, a mTOR kinase inhibitor, as a promising anti
Usnic acid inhibits growth and induces cell cycle arrest and apoptosis in human lung carcinoma A549 cells PMID 23682781
5
Demethyl
S100a1 Rat Pre
flavan
S
Hypocretin Mediates Sleep and Wake Disturbances in a Mouse Model of Traumatic Brain Injury PMID 30136622
S
L
The bradykinin analog RMP
Activity of 2,4
(E)
Biosynthesis of kitasamycin (leucomycin) by leucine analog
PDRN 100403
Apigenin 6
Dual ferroptosis induction in N2
ML239
The clecarmycins, new antitumor antibiotics produced by Streptomyces fermentation, isolation and biological properties PMID 7592019
Increased dNTP pools rescue mtDNA depletion in human POLG
JNJ
Anti
SC
Mrap
Akap3
Vortosiran
Lrpap1 Mouse Pre
Feruloyl
Human P2Y1 receptor molecular modeling and site
CRBN ligand
The pharmacology and therapeutic potential of (
GLP
Small molecule Y
Confusameline 20643
UNBS5162 inhibits colon cancer growth via suppression of PI3K/Akt signaling pathway PMID 30403183
AILDE Computer
CRBN ligand
Purification and kinetic properties of protein kinase C from cultured smooth muscle cells PMID 7684292
Small
Jacaranone 60263
Steroid
Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy Design, synthesis, and evaluation of novel 4
Synergic effect in the reduction of serum uric acid level between ethanol extract of Aster glehni and vitamin B6 PMID 30319854
S
Design, chemical synthesis and antiviral evaluation of 2'
CRBN ligand
Isobutyramide
CRBN ligand
Antiflammin 3
RKER
蛋白磷酸酶 1 催化亚基 γ（PPP1CC）基因
Urodilatin regulates renal dopamine metabolism PMID 23661592
5(S)
Angelic acid triggers ferroptosis in colorectal cancer cells via targeting and impairing NRF2 protein stability PMID 39433724
Sulfamoylbenzamide derivatives inhibit the assembly of hepatitis B virus nucleocapsids PMID 23576513
Structural manipulation of aporphines via C10 nitrogenation leads to the identification of new 5
unc
CRBN ligand
Efnb3 Mouse Pre
Coumarin
Efficacy of mipragoside ophthalmic gel in vernal keratoconjunctivitis PMID 8944090
CRBN ligand
Veratric acid
Hydroxy
含 kelch 域 3（KLHDC3）基因
BI1071, a Novel Nur77 Modulator, Induces Apoptosis of Cancer Cells by Activating the Nur77
Acropyrone
Deltorphin 2 TFA ([D
Triclosan exposure, transformation, and human health effects PMID 29182464
A neutralizing anti
Multivalent peptide dendrimers inhibit the fusion of viral
Use of [3H]fluorowillardiine to study properties of AMPA receptor allosteric modulators PMID 16256076
mex
(3S)
Macrocyclic Hedgehog Pathway Inhibitors Optimization of Cellular Activity and Mode of Action Studies PMID 23074541
CRBN ligand
Tasquinimod (ABR
[Metabolic pathway and metabolites of pseudolaric acid B] PMID 22260030
TL1A/TNFSF15 蛋白, Cynomolgus/Rhesus macaque (HEK293, His)
Caramiphen 77
The acute toxicity of perfluorooctanoic and perfluorodecanoic acids in male rats and effects on tissue fatty acids PMID 6636169
Acd Rat Pre
CASP7
Alpha 1
CRBN ligand
CRBN ligand
TL1A/TNFSF15 蛋白, Mouse (HEK293, Fc)
Effects of the selective 5
Discovery, design and synthesis of novel potent and selective sphingosine
Discovery of the therapeutic potential of naltriben against glutamate
Rift
Cytotoxic effects of maleuric acid and the structurally related compounds on Ehrlich ascites tumor cells PMID 13939761
CRBN ligand
S 421
Gly
Identification of a peptidase which processes atrial natriuretic factor precursor to its active form with 28 amino acid residues in particulate fractions of rat atrial homogenate PMID 2952119
Interactions of a nonpeptidic drug, valacyclovir, with the human intestinal peptide transporter (hPEPT1) expressed in a mammalian cell line PMID 10087037
Octoclothepin maleate salt 4789
XL388
Griseolic acid B 98890
Bryostatin 1 83314
L
CRBN ligand
CRBN ligand
联癸烷 4（SDC4）基因
Anti
SEL1L Human Pre
Mangiferin 4773
Tryptophol
Potential anti
CD22 Blockage Restores Age
Xanthohumol 6754
MCE
CD131 蛋白, Human (HEK293, hFc)
Mordant red 19 1934
From Diarylsulfides to Diarylamines New Ebola Virus Entry Inhibitors with Improved Metabolic Stability PMID 40381209
A Novel Mitragynine Analog with Low
Cholesterol esterase a cholesterol transfer protein PMID 7696259
Lack of urinary bladder carcinogenicity of sodium L
CRBN ligand
The combined therapy myo
MIP
Mibenratide 1239011
β
(S)
9684
CRBN ligand
Azo
α
MCE
Bevantolol hydrochloride 42864
Benzo[a]pyrene diol epoxide 58917
Bathophenanthrolinedisulfonic acid disodium 52746
CAB39 Human Pre
S
CRBN ligand
Structure
Neopanaxadiol 1203590
Phase I results of S49076 plus gefitinib in patients with EGFR TKI
Comparison of Carboxybetaine with Sulfobetaine as Lipid Headgroup Involved in Intermolecular Interaction between Lipids in the Membrane PMID 31457839
Citicoline sodium 33818
Memnobotrin B 256235
Arl6
CRBN ligand
Human umbilical vein vasoconstriction induced by epinephrine acting on alpha1B
17β
CCAR1 Human Pre
Resorufin 635
N
Bacterial production of latarcin 2a, a potent antimicrobial peptide from spider venom PMID 18455432
Acid Red 337 67786
2
PCK2
Penfluron 35367
3,5
GIPR antagonist 2
CRBN ligand
SC
Phenanthridine (菲啶)
AMT
Brap Rat Pre
Emodin 6
MCE
Antioxidant behavior of mearnsetin and myricetin flavonoid compounds
3
Levocetirizine dihydrochloride 130018
Scopoletin and scopolin isolated from Artemisia iwayomogi suppress differentiation of osteoclastic macrophage RAW 264.7 cells by scavenging reactive oxygen species PMID 23510022
CRBN ligand
BD
Octadecyl caffeate 69573
S
Cancer chemopreventive activity mediated by 4'
LPP Tripeptide 121305
Soluble CD137 (4
2
Sult1c2 Mouse Pre
Novel dammarane
Discovery of New Azaindole Metallo
Ellagic acid 476
AXL
3
Nifurtoinol 1088
Methotrexate embryopathy after exposure to low weekly doses in early pregnancy PMID 24513926
H
2
Norrubrofusarin 3566
CRBN ligand
OVA(250
5,10
Monamycin B 31556
Moracin M 56317
TP
CRBN ligand
Antitumor studies. Part 5 Synthesis, antitumor activity, and molecular docking study of 5
Ro 23
Demeton
Mal
Atomoxetine 83015
Tiglyl Glycine
红铁木桉提取物 (Eucalyptus sideroxylon A.Cunn. ex Woolls)
Discovery of novel, orally bioavailable phenylacetamide derivatives as multikinase inhibitors and in vivo efficacy study in hepatocellular carcinoma animal models PMID 39306048
CRBN ligand
Cadmium promotes nonalcoholic fatty liver disease by inhibiting intercellular mitochondrial transfer PMID 37884867
Isozyme
MB725 2230058
H111
Clinical Pharmacokinetics of indomethacin PMID 7249487
In vitro oxidation of famciclovir and 6
Sdhc
Accumulation of amyloid precursor protein C
Investigation of two different human d
CRBN ligand
15(S)
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