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CDK6 Immunophenotype Implicates Potential Therapeutic Application of CDK4/6 Inhibitors in Urothelial Carcinoma PMID 35463324
LAIR1 Human Pre
Cyclo(L
Chd6 Mouse Pre
MCE
Piceatannol 10083
2
MCE
MCE
Evaluation of anti
LQEQ
ACD
Ethyl icosanoate 18281
MCE
2,3,4
G protein
SRF 抗体 (YA6778)（SRF Antibody (YA6778)）
ST7612AA1, a thioacetate
Reproterol 54063
KAG
GRASP55 and UPR Control Interleukin
H
Methyldopa hydrochloride 884
Nitric oxide inhibitory coumarins from the roots and rhizomes of Notopterygium incisum PMID 30291965
ASPM promotes migration and invasion of anaplastic thyroid carcinoma by stabilizing KIF11 PMID 36883909
alpha
Vitamin D promotes wound healing in aged skin by modulating inflammation, angiogenesis, and EMT via the Hippo pathway PMID 40466431
Targeting ROCK1/YAP1 Axis Ameliorates Inflammation
GSK
ARID1A recruits GATA2 to regulate the senescence of trophoblast cells under high
Dipsacus saponin A 99624
Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines PMID 30785039
Design, synthesis and neuropharmacological evaluation of new 2,4
Yamogenin in fenugreek inhibits lipid accumulation through the suppression of gene expression in fatty acid synthesis in hepatocytes PMID 25229863
Antioxidant Activity and Volatile and Phenolic Profiles of Essential Oil and Different Extracts of Wild Mint (Mentha longifolia) from the Pakistani Flora PMID 24224115
BPHA 193807
Dual
o
KD
MM0299 474255
Autoimmune uveitis elicited with antigen
Aniline blue (alcohol soluble)
Removal and toxic intervention of polystyrene microplastics and nanoplastics by magnetic nano
Benzyldimethylstearylammonium chloride 122
The structural and functional analysis of mycobacteria cysteine desulfurase
Genome
Tyrosinase
SRT1720 attenuates UVA
COH1 20217
4
Combined inhibition of heat shock proteins 90 and 70 leads to simultaneous degradation of the oncogenic signaling proteins involved in muscle invasive bladder cancer PMID 26556859
PFOA exposure promotes prostate cancer progression by enhancing autophagy through m6A modification of MAPK15 mRNA PMID 40784096
Fangchinoline Exerts Anticancer Effects on Colorectal Cancer Cells by Evoking Cell Apoptosis via Endoplasmic Reticulum Stress PMID 37052856
One
Evidence that prohexadione
Isopentyl 3
Quercetin Improves Lipopolysaccharide
Decreased organ failure in patients with severe SIRS and septic shock treated with the platelet
T
Function and mechanism exploration of zinc finger protein 64 in lung adenocarcinoma cell growth and metastasis PMID 33054540
Novel isatinyl thiosemicarbazones derivatives as potential molecule to combat HIV
2
Engineered cell membrane vesicles loaded with lysosomophilic drug for acute myeloid leukemia therapy via organ
Disulfiram Enhances the Activity of Polymyxin B Against Klebsiella pneumoniae by Inhibiting Lipid A Modification PMID 35115797
MCE
Quinoline
Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL
PTX
Chidamide and mitomycin C exert synergistic cytotoxic effects against bladder cancer cells in vitro and suppress tumor growth in a rat bladder cancer model PMID 35033588
High
Butyrolactone I attenuates inflammation in murine NASH by inhibiting the NF
含 MIA SH3 域（MIA）基因
LS2265 72678
Stearyl arachidate (Arachidic acid stearyl ester)
Latanoprost acid (Standard)
Screen of anti
New and bioactive compounds from Streptomyces strains residing in the wood of Celastraceae PMID 12430026
MCE
Clothiapine 2058
alkene
Neuroimmunophilin ligands exert neuroregeneration and neuroprotection in midbrain dopaminergic neurons PMID 11359520
MCE
Chlorocresol (4
MCE
N,N
The cytoplasmic prolyl
Selective suppression of oligodendrocyte
Curcuminoid Demethylation as an Alternative Metabolism by Human Intestinal Microbiota PMID 28401758
Sulfapyridine 144
Bromamphenicol 17371
MCE
MCE
Striking the Optimal Solubility
Pretilachlor 51218
5'
Towards novel S
Neutrophil Extracellular Traps Induce Brain Edema Around Intracerebral Hematoma via ERK
A new iridoid glycoside from the roots of Dipsacus asper PMID 22306831
Pheophorbide A 15664
Activity and tolerability of tetridamine vaginal lavage in rats and women PMID 1418890
Gomisin N rescues cognitive impairment of Alzheimer's disease by targeting GSK3β and activating Nrf2 signaling pathway PMID 38924927
14 0 PE
BN 52111 120889
Discovery of novel dual Bruton's tyrosine kinase (BTK) and Janus kinase 3 (JAK3) inhibitors as a promising strategy for rheumatoid arthritis PMID 37944414
Kinetic models for the dynamical behavior of polyacrylamide (PAAm)
PKA
Targeting AKT1
Gossypetin is a novel MKK3 and MKK6 inhibitor that suppresses esophageal cancer growth in vitro and in vivo PMID 30391783
Olopatadine
成纤维细胞生长因子受体 4（FGFR4）基因
Preischemic and postischemic treatment with a new Na+/H+
Flutax 1 191930
Exploring the ATR
FUNDC2 promotes liver tumorigenesis by inhibiting MFN1
Aurantiamide promotes M2 polarization of microglial cells to improve the cognitive ability of mice with Alzheimer's disease PMID 36062448
Combined application of Indocyanine green (ICG) and laser lead to targeted tumor cell destruction PMID 30244940
The Small Molecule P7C3
EGFR
VU041 332943
A new insight into the photochemistry of avobenzone in gas phase and acetonitrile from ab initio calculations PMID 27443629
Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530 PMID 19393585
MCE
ARI
MCE
GNE
MCE
Ala
Tretazicar 21919
Apazunersen 2919324
LINCS L1000 dataset
HAS2 Human Pre
XL 999 (Standard)
Chlorido[N,N'
Benzophenones and xanthones with isoprenoid groups from Cudrania cochinchinensis PMID 11170668
Nano
Lzts1 Mouse Pre
NAD+ metabolism controls growth inhibition by HIF1 in normoxia and determines differential sensitivity of normal and cancer cells PMID 34382917
条纹藁本提取物 (Ligusticum striatum DC.)
W
2
Trop2 binding IGF2R induces gefitinib resistance in NSCLC by remodeling the tumor microenvironment PMID 34335947
PSMC2 Human Pre
Control of translational activation by PIM kinase in activated B
Distinct STING
A11
MCE
Lactate exacerbates neuroinflammation in sepsis
Metformin suppresses gammadelta T17 cell differentiation alleviating DSS
MCE
A rewiring of DNA replication mediated by MRE11 exonuclease underlies primed
Dimethyl pyridine
Small molecule inhibition of phosphatidylinositol
A comparative study of antioxidative activity of calcium
HDAC
cGAS guards against chromosome end
Neophellamuretin 52589
Monochlorobimane (Chlorobimane，mBBr)
SRA1 Human Pre
A
A resurgence of β
MCE
Evaluation of the oral antimitotic agent (ABT
Effect of EGCG on bronchial epithelial cell premalignant lesions induced by cigarette smoke and on its CYP1A1 expression PMID 34676878
Phytic acid in health and disease PMID 8777015
Tombozine 604
Lithocholic acid
Small molecule non
Benzoyl (S)
I194496
AFM 24
Silydianin 29782
A class of 3S
A disease
EGFR/EGFRvIII partly regulates the tumourigenesis of glioblastoma through the SOX9
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes PMID 18046409
WAY 267,464, a non
C
Dopaminergic Projections From the Ventral Tegmental Area to the Nucleus Accumbens Modulate Sevoflurane Anesthesia in Mice PMID 33994950
CXCR1 and CXCR2 Inhibition by Ladarixin Improves Neutrophil
Pathogenic variants in DLGAP5 cause female infertility characterized by oocyte maturation arrest and embryonic arrest PMID 40639803
Oxazole blue 157199
A small
Design, synthesis and antitumor activity of novel thiophene
CY3
Mebendazole
GNE
NF
Desmethylamitriptyline (Standard)
PD318088 391210
Pemedolac 114716
bladder cancer
Ixazomib citrate 1239908
Adenine
RG 15
Vepdegestrant
RSK1 promotes mammalian axon regeneration by inducing the synthesis of regeneration
Recent advances in antiviral therapy PMID 10396233
Dimeric pyrrolidinoindoline
Cellular
PHA
Palmitoyl serinol 126127
Synthesis and structure
MGST1 Protects Pancreatic Ductal Cells from Inflammatory Damage in Acute Pancreatitis by Inhibiting Ferroptosis Bioinformatics Analysis with Experimental Validation PMID 40076525
Ifoxetine hemisulfate 98518
A screening pattern recognition method finds new and divergent targets for drugs and natural products PMID 24802392
7
2,4
Adrenal gland macrophages regulate glucocorticoid production through Trem2 and TGFβ PMID 38869957
Tumor Necrosis Factor Receptor
Discovery of Small Molecule Splicing Modulators of Survival Motor Neuron
Beyond Substituted p
Funiculosin 11055
HDAC8
Boc
Multipathway regulation induced by 4
TMEM9 promotes lung adenocarcinoma progression via activating the MEK/ERK/STAT3 pathway to induce VEGF expression PMID 38664392
Design, synthesis and biological evaluation of novel N
MCE
Alexidine Dihydrochloride Has Broad
Has2 Mouse Pre
The bacterial metabolite 2
PAR1
MCE
2
MCE
长棒柄花提取物 (Cleidion spiciflorum (Burm. f.) Merr.)
Efficacy of ETI
MB
VF
4
Enantioselectivity of thalidomide serum and tissue concentrations in a rat glioma model and effects of combination treatment with cisplatin and BCNU PMID 17227627
TGFβ
MCE
MCE
Evaluation of the use of chromogenic and fluorogenic substrates in solid
Malt1 Mouse Pre
2
Cholesta
MCE
Sirt1 inhibition promotes in vivo arterial thrombosis and tissue factor expression in stimulated cells PMID 20978007
MCE
Mechanistic Assessment of Extrahepatic Contributions to Glucuronidation of Integrase Strand Transfer Inhibitors PMID 30804050
Artemether
ZZM
PqsR
N6
The crucial role of IL
PLCβ
Para
Structure
Isobavachalcone prevents osteoporosis by suppressing activation of ERK and NF
Virus
Antiviral activity of merimepodib against foot and mouth disease virus in vitro and in vivo PMID 31386979
Novel AMPA receptor potentiators LY392098 and LY404187 effects on recombinant human AMPA receptors in vitro PMID 11406188
CT
Sevoflurane attenuates brain damage through inhibiting autophagy and apoptosis in cerebral ischemia‑reperfusion rats PMID 31746402
Azido
Ferruginol
UR
tert
Molecular biology of the natriuretic peptides and their receptors PMID 1327579
MCE
Ganoderic acid A holds promising cytotoxicity on human glioblastoma mediated by incurring apoptosis and autophagy and inactivating PI3K/AKT signaling pathway PMID 31503386
TAS
Zalcitabine. An update of its pharmacodynamic and pharmacokinetic properties and clinical efficacy in the management of HIV infection PMID 9179531
SRF Human Pre
Ganglioside GD3 diammonium
XRCC6 Human Pre
Sensory neuron subpopulation
Mad2 Inhibitor
Transcriptomic heterogeneity of cultured ADSCs corresponds to embolic risk in the host PMID 35992088
Mebeverine acid
Design, synthesis and evaluation of the osimertinib analogue (C
(2R,3S)
In vitro skin permeation of potassium hexachloroplatinate and a comparison with potassium tetrachloroplatinate PMID 37075869
Carbimazole 22232
N
Identification of novel phenyl butenonyl C
Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion PMID 35922515
Cyanidin
WAY 163909 428868
N
Small
Strn Mouse Pre
3
Fibrinogen
MCE
MCE
MCE
Small extracellular vesicles derived from mesenchymal stromal cells loaded with β
NCAPG promotes the proliferation of hepatocellular carcinoma through the CKII
BET
Amido Black 10B 1064
Attenuation of inflammatory polyarthritis in TNF transgenic mice by diacerein comparative analysis with dexamethasone, methotrexate and anti
Non
FABP4
Echinococcus multilocularis
7β,25
Effective and Rapid Generation of Functional Neutrophils from Induced Pluripotent Stem Cells Using ETV2
FcγRIIb Exacerbates LPS
Gouqi
A review of the discovery, pharmacological characterization, and behavioral effects of the dopamine D2
Z
Design, Synthesis, and Preliminary Evaluation of [68Ga]Ga
Stochastic bacterial population dynamics restrict the establishment of antibiotic resistance from single cells PMID 32703812
GW994
Enhanced powder dispersion of dual
Discovery of Highly Potent Dual CysLT1 and CysLT2 Antagonist PMID 25408836
Aza
A Small Molecular Weight Saccharide Fraction From Panax quinquefolium L. Inhibited Non
Calmodulin antagonistic action of the cerebral circulation improver 6,7
Free radical scavenger 1
CXCL3 positively regulates adipogenic differentiation PMID 27512010
N,N
rel
Berberine mitigates nonalcoholic hepatic steatosis by downregulating SIRT1
Downregulation of Lnc
Aselizumab 395639
N
Structure
Identification of hydrolyzable tannins (punicalagin, punicalin and geraniin) as novel inhibitors of hepatitis B virus covalently closed circular DNA PMID 27591143
MCE
Elevating VAPB
MCE
MCE
Procymidox
MCE
MCE
AMPK activates Parkin independent autophagy and improves post sepsis immune defense against secondary bacterial lung infections PMID 34117280
BMS1 核糖体生物发生因子（BMS1）基因
MCE
KY
Rosiglitazone 122320
Polr1b
Acacetin improves endothelial dysfunction and aortic fibrosis in insulin
Glemanserin (Standard) (MDL11939 (Standard))
3’
MCE
CID1231538
CCR1 antagonist 7
H2
FIGN Human Pre
3
Design, synthesis, and biological evaluation of triazolo
Epirubicin, Identified Using a Novel Luciferase Reporter Assay for Foxp3 Inhibitors, Inhibits Regulatory T Cell Activity PMID 27284967
Carbimazole
Effects of dotarizine and flunarizine on chromaffin cell viability and cytosolic Ca2+ PMID 10082213
H
Activity of azithromycin or erythromycin in combination with antimalarial drugs against multidrug
PTH receptor
MCE
Antitumor agent
Discovery and development of potent and selective inhibitors of histone methyltransferase g9a PMID 24900801
Acetaminophen is an inhibitor of hepatic N
Integrated multi
Non
4
Synthesis and structure
Citrus flavonoid 3,5,6,7,8,3',4'
Binospirone hydrochloride 102908
D156844
Angoline hydrochloride 1071676
AZ6102
Synthesis and structure
Characterization of the interactions of potent allosteric inhibitors with glutaminase C, a key enzyme in cancer cell glutamine metabolism PMID 29317493
Lug
PLLA1000
Neutrophil elastase
MCE
Chaf1a
Exogenous Local Hyperthermia at 41℃ Is Effective to Eliminate Mouse Model of Sporotrichosis, Independent of Neutrophil Extracellular Traps Formation PMID 33911810
tert
Phase Transitions of PYR14
Identification of sanguinarine as a novel antagonist for perfluorooctanoate/perfluorooctane sulfonate
Decanoyl
AQP4 Human Pre
FGFR2 N549H Recombinant Human Active Protein Kinase
LCB
11
N
Palmityl arachidate
miR
MCE
Celastrol (Standard)
Tremor
Lanosterol influences cytoplasmic maturation of pig oocytes in vitro and improves preimplantation development of cloned embryos PMID 26494176
KRAS WT Peptide
LC3B/p62
MCE
Microcapsule
Cy3
Translational research into species differences of endocrine toxicity via steroidogenesis inhibition by SMP
STRN3 Human Pre
Unveiling the hidden interactome of CRBN molecular glues PMID 40707481
N
Rational design and validation of a Tip60 histone acetyltransferase inhibitor PMID 24947938
Hainantoxin
β
Effects of rifampicin on the pharmacokinetics of alflutinib, a selective third
Synthetic libraries of immune cells displaying a diverse repertoire of chimaeric antigen receptors as a potent cancer immunotherapy PMID 35668107
Characterization of brassinazole, a triazole
Restoration of the type I IFN
Cytotoxic Lipopeptide Muscotoxin A, Isolated from Soil Cyanobacterium Desmonostoc muscorum, Permeabilizes Phospholipid Membranes by Reducing Their Fluidity PMID 25621379
(S)
Lung microbiota metabolite L
Chemical synthesis, pharmacological evaluation and in silico analysis of new 2,3,3a,4,5,6
αTC
Lancao decoction in the treatment of alzheimer's disease via activating PI3K/AKT signaling to promote ERK involving in enhancing neuronal activities in the hippocampus PMID 39528121
Histone lactylation regulates DOCK4 to control heat nociception and supports Dynein
Sphingosine 1
Anti
RNPA1000 359600
Immunomodulation of inflammatory responses preserves retinal integrity in murine models of pericyte
Novel tumor suppressor function of glucocorticoid
Inhibitory effect of nintedanib on VEGF secretion in retinal pigment epithelial cells induced by exposure to a necrotic cell lysate PMID 31386668
Ingenane Diterpenoids from Euphorbia peplus as Potential New CHK1 Inhibitors That Sensitize Cancer Cells to Chemotherapy PMID 40056138
(+)
Trabodenoson 871108
Enrofloxacin/BSA (恩诺沙星牛血清白蛋白偶联物)
Quinidine
MCE
MCE
Discovery of novel benzothiophene derivatives as potent and narrow spectrum inhibitors of DYRK1A and DYRK1B PMID 35504513
Combined Treatment of Uterine Leiomyosarcoma with Gamma Secretase Inhibitor MK
MCE
Harnessing the SPOP E3 Ubiquitin Ligase via a Bridged Proteolysis Targeting Chimera (PROTAC) Strategy for Targeted Protein Degradation PMID 40202531
DNA Gyrase
Lamivudine improves cognitive decline in SAMP8 mice Integrating in vivo pharmacological evaluation and network pharmacology PMID 34374199
FGFR1 inhibitor
MEK5/ERK5 signaling inhibition increases colon cancer cell sensitivity to 5
Inhibition of ovulation in rats with epostane, an inhibitor of 3 beta
[STUDIES ON ANTITUMOR DRUGS. VII. STUDIES ON THE ANTITUMOR SPECTRUM AND TOXICITY OF N
Cellular effects of purvalanol A a specific inhibitor of cyclin
MCE
Atmospheric degradation of the organothiophosphate insecticide
VSM
Design and Synthesis of some new 2,4,6
Effects of Alda
1,2
AL 321
LB 100
Prionanthoside (早开堇菜苷)
Synthesis and cytotoxic activity of a new series of topoisomerase I inhibitors PMID 18248813
Hirsutanonol 5
SARS
Primitive cardiac cells from human embryonic stem cells PMID 21933026
Biochemical mechanism of modulation of human P
Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer PMID 27798265
BPTU 870544
Maleimide cross
Combination of chemotherapy and oxidative stress to enhance cancer cell apoptosis PMID 34122827
Japanese Encephalitis Virus Induces Apoptosis and Encephalitis by Activating the PERK Pathway PMID 31189710
Two new roridins isolated from Myrothecium sp PMID 11513043
Screening active fractions from Pinus massoniana pollen for inhibiting ALV
MCE
The ROS/CaMK II/β
Transient autophagy inhibition strengthened postharvest tomato (Solanum lycopersicum) resistance against Botrytis cinerea through curtailing ROS
Interleukin
Novel orally active growth hormone secretagogues PMID 9733496
MM
DRUG FOCUS S 18986 A positive allosteric modulator of AMPA
Massive entry of BK Polyomavirus induces transient cytoplasmic vacuolization of human renal proximal tubule epithelial cells PMID 39570904
Microglia contribute to mammary tumor
scavenger
Hadacidin sodium 2618
CDK2/CycD1 Recombinant Human Active Protein Kinase
Chlorocholine chloride and paclobutrazol treatments promote carbohydrate accumulation in bulbs of Lilium Oriental hybrids 'Sorbonne' PMID 22302427
Trim21 deficiency alleviates osteoporosis by inhibiting osteoclast differentiation through regulating Txnip PMID 40751213
Back to the future Advances in development of broad
visibly red dye
CTSH Human Pre
JAM
ML 315 1440251
SV119 913815
Spautin
4
Suppression of the hypothalamic
Identification and Characterization of Tyrosine Kinase Nonreceptor 2 Mutations in Leukemia through Integration of Kinase Inhibitor Screening and Genomic Analysis PMID 26677978
Dopamine 3
MCE
Transformation of the amyloidogenic peptide amylin(20
Bio
CENPA Human Pre
MCE
Computational analysis reveal inhibitory action of nimbin against dengue viral envelope protein PMID 26645034
Endothelin ET(A) receptor antagonism attenuates the pressor effects of nicotine in rats PMID 10822051
Phenylglyoxylic acid (Benzoylformic acid，苯甲酰甲酸)
Effects of quinotolast, a new orally active antiallergic drug, on experimental allergic models PMID 7505860
L
Ciclopirox suppresses poxvirus replication by targeting iron metabolism PMID 40777304
Incorporation of metabolically stable ketones into a small molecule probe to increase potency and water solubility PMID 26231156
MCE
TAM557 1802499
N
MCE
In vitro and in vivo activities of KSP
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