最近收录_第598页_生物活性分子
生物活性分子最近更新
Intraoperative near
Engineered small extracellular vesicles loaded with miR
Mapping and engineering RNA
MCE
Antipsychotic drug
Discovery of 3
DSPC
Mechano
Discovery of the selective androgen receptor modulator MK
Desulfated hirugen (hirudin 54
Atractylodes macrocephala III suppresses EMT in cervical cancer by regulating IGF2BP3 through ETV5 PMID 38358034
In Silico HTS and Structure Based Optimization of Indazole
Detachable Dual
Targeting EGFR/HER2 tyrosine kinases with a new potent series of 6
Complement C3 Produced by Macrophages Promotes Renal Fibrosis via IL
Ex vivo removal of pro
Tachykinin receptor subtypes in the isolated guinea pig heart and their role in mediating responses to neurokinin A PMID 10871306
Herpes simplex virus type 1 entry is inhibited by the cobalt chelate complex CTC
Design, Optimization, and Development of RIPK1 Degraders with Improved Pharmacokinetic and Pharmacodynamic Properties PMID 41134612
The Na+/Ca2+ exchange inhibitor 2
MCE
Potent anti
miR
Ultrasound Microbubble
Leucodelphinidin 491
Discovery of Covalent CDK14 Inhibitors with Pan
Isolation of two toxic heptapeptide microcystins from an axenic strain of Microcystis aeruginosa, K
Cynatratoside D 97399
Analgesic effects of metapramine and evidence against the involvement of endogenous enkephalins in the analgesia induced by tricyclic antidepressants PMID 2827090
Biological Mechanisms of Paeonoside in the Differentiation of Pre
Recent advances of analogues of curcumin for treatment of cancer PMID 31336310
Monophosphoryl lipid A induces protection against LPS in medullary thick ascending limb through induction of Tollip and negative regulation of IRAK
SOX10 Regulates Melanoma Immunogenicity through an IRF4
Treatment of secondary brain injury by perturbing postsynaptic density protein
TCTA Human Pre
Neuroprotective effects of erythromycin on cerebral ischemia reperfusion
Peroxidation of arachidonate containing plasmenyl glycerophosphocholine facile oxidation of esterified arachidonate at carbon
Real
Cytosolic phospholipase A2 alpha regulates cell growth in RET/PTC
Clopidogrel
KRAS inhibitor
USP1
Deubiquitinating PABPC1 by USP10 upregulates CLK2 translation to promote tumor progression in pancreatic ductal adenocarcinoma PMID 37757903
CLEC2D
Agarsenone, a Cadinane Sesquiterpenoid from Commiphora erythraea PMID 23844767
Differential potencies of naturally occurring regioisomers of nitrolinoleic acid in PPARgamma activation PMID 19105608
MCE
Novel Cyanopyridine Compounds as KHK Inhibitors for Treating NAFLD, NASH, and Type II Diabetes PMID 39140057
11β
Butyl diphenyl phosphate 2752
Methacholine challenge methods PMID 18842907
Identification of a Compound Inhibiting Both the Enzymatic and Nonenzymatic Functions of Indoleamine 2,3
Unexpected Discovery of Dichloroacetate Derived Adenosine Triphosphate Competitors Targeting Pyruvate Dehydrogenase Kinase To Inhibit Cancer Proliferation PMID 27006991
Changes in gefitinib, erlotinib and osimertinib pharmacokinetics under various gastric pH levels following oral administration of omeprazole and vonoprazan in rats PMID 29057719
Sp
High glucose
Investigating amine derivatives of ambruticin VS
A two
Targeting LIPA independent of its lipase activity is a therapeutic strategy in solid tumors via induction of endoplasmic reticulum stress PMID 35654861
Rational Design of a Potential New Nematicide Targeting Chitin Deacetylase PMID 38264997
Ruthenium red 11103
Discovery of a Novel Thienopyrimidine Compound as a Urate Transporter 1 and Glucose Transporter 9 Dual Inhibitor with Improved Efficacy and Favorable Druggability PMID 38482820
Protein
Tumor
TLR2 senses the SARS
Melatonin Ameliorates Cisplatin
Crocetin inhibits choroidal neovascularization in both in vitro and in vivo models PMID 38097101
4
MCE
MCE
Aerobic glycolysis promotes tumor immune evasion by hexokinase2
Rational design of indoleamine 2,3
Butyrophenone 495
Discovery of N
Safer non
Ethotoin
Ulixacaltamide (Z944)
Benzomalvin C
KW
11
Adenylosuccinic acid (Adenylosuccinate)
The importance of the nine
In vitro cytotoxicity and in vivo efficacy, pharmacokinetics, and metabolism of 10074
Acid orange 7 633
1,3
多重肌醇聚磷酸酶 1（MINPP1）基因
Dezinamide 91077
PD176252
HIV protease inhibitors Nelfinavir and Lopinavir/Ritonavir markedly improve lung pathology in SARS
Angiopoietin
NLRP3
Fully human, HLA
Molecular cloning, expression, and sequence analysis of the endoglycoceramidase II gene from Rhodococcus species strain M
Effect of the peroxisome proliferator
ZBTB28 inhibits breast cancer by activating IFNAR and dual blocking CD24 and CD47 to enhance macrophages phagocytosis PMID 35048182
Orexin A alleviates chronic cerebral hypoperfusion
USP2 inhibition unleashes CD47
Cyclic GMP
Bidirectional crosstalk of the cAMP/ROS
Cathepsin S Regulates Antigen Processing and T Cell Activity in Non
MA
Chemogenetic System Demonstrates That Cas9 Longevity Impacts Genome Editing Outcomes PMID 33376784
Improving Lipophagy by Restoring Rab7 Cycle Protective Effects of Quercetin on Ethanol
Myostatin knockout induces apoptosis in human cervical cancer cells via elevated reactive oxygen species generation PMID 30241032
PST 2238 A new antihypertensive compound that modulates Na,K
ACSL1
PD
anionic
Efna3
DKN
Pigment Yellow 183
SKL2001 suppresses colon cancer spheroid growth through regulation of the E
Traumatic Acid 6402
Discovery of novel N
BCRP drives intrinsic chemoresistance in chemotherapy
Acetylisoniazid 1078
Vedolizumab 943609
Synthesis, anticancer activity and mitochondrial mediated apoptosis inducing ability of 2,5
In vitro pharmacology of a nonpeptidic angiotensin II receptor antagonist, SC
2
Cucurbitane triterpenoid entities derived from Hemsleya penxianensis triggered glioma cell apoptosis via ER stress and MAPK signalling cross
Kras4B 蛋白, Human (G12C, His)
LncRNA XIST from the bone marrow mesenchymal stem cell derived exosome promotes osteosarcoma growth and metastasis through miR
Ethyl (Z)
Discovery of Highly Potent, Selective, and Liver
High
MCE
MCE
MCE
Suppression of cideb under endoplasmic reticulum stress exacerbated hepatic inflammation by inducing hepatic steatosis and oxidative stress PMID 35489563
MCE
LGADMEDVCG
In
Helenalin
SNORD3A Regulates STING Transcription to Promote Ferroptosis in Acute Kidney Injury PMID 38962954
Role of microtubules in late
Identification of novel anti
An investigation of the H1
Synthesis and Bioevaluation of 3
Keto
An in vivo CRISPR screen identifies that SNRPC promotes triple
K
A spinal muscarinic M2 receptor
TH16
Insights Into the Molecular Aspects of Neuroprotective Bacoside A and Bacopaside I PMID 29676230
Compound collagen peptide powder improves skin photoaging by reducing oxidative stress and activating TGF
Rewiring Estrogen Receptor α into Bisphenol Selective Receptors Using Darwin Assembly
Structure
Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4 PMID 18664603
The synthesis of 4,7
Activation of peroxisome proliferator
MYBPC3 D389V Variant Induces Hypercontractility in Cardiac Organoids PMID 38853909
Discovery of Novel Small
Temocaprilat 110221
Affinity of Bandeiraea (Griffonia) simplicifolia lectin
Discovery of GNE
Neurokinin and NMDA antagonists (but not a kainic acid antagonist) are antinociceptive in the mouse formalin model PMID 1711193
LRPAP1 蛋白, Human (HEK293, C
IL
Divergent functions of endotrophin on different cell populations in adipose tissue PMID 27729337
Fmoc
S
Geraniol, a natural monoterpene, ameliorates hyperglycemia by attenuating the key enzymes of carbohydrate metabolism in streptozotocin
ADORA2A/PDE4D
NCAM1 Human Pre
Hydroxamic acid based histone deacetylase inhibitors with confirmed activity against the malaria parasite PMID 25563890
The sialidase inhibitor 2,3
MCE
MCE
(S)
Bafilomycin A1 targets both autophagy and apoptosis pathways in pediatric B
Tumor
Dracorhodin perchlorate induces the apoptosis of glioma cells PMID 26846469
A Reduction in B, T, and Natural Killer Cells Expressing CD38 by TAK
The Somatostatin Receptor
SCAF1 Human Pre
(S)
Gluten Exorphin C
MNI
ESRRG Human Pre
The comparative effects of aminoglycoside antibiotics and muscle relaxants on electrical field stimulation response in rat bladder smooth muscle PMID 27260628
RICTOR/mTORC2 affects tumorigenesis and therapeutic efficacy of mTOR inhibitors in esophageal squamous cell carcinoma PMID 32642408
A Potent and Selective CDKL5/GSK3 Chemical Probe is Neuroprotective PMID 36798313
Glutathione S
PARP3 promotes macrophage inflammation via mono ADP ribosylation of Ppia Glu140 PMID 40461998
Mearnsetin 16805
Body, metabolic and renal changes following cross
Clobetasol propionate
Aifm1 Rat Pre
7H
N omega
Influence of membrane fluidity on the assembly of Staphylococcus aureus alpha
MET and AXL inhibitor NPS
Bridging the Translation of ICG
9
RRMM
Neutrophil extracellular traps induced by the hypoxic microenvironment in gastric cancer augment tumour growth PMID 37127629
non
Zoligratinib (Debio 1347)
6
Novel anti
Effect on hepatitis C virus replication of combinations of direct
CDRI
Aerothionin 28714
Basiliximab a review of its use as induction therapy in renal transplantation PMID 20055533
membrane
5,7
Antisense inhibition of coagulation factor XI prolongs APTT without increased bleeding risk in cynomolgus monkeys PMID 22246038
The constitutive androstane receptor is an anti
In vitro and in vivo activity of GT
Retinoic acid
Bulbocapnine is not a selective DA1 receptor antagonist PMID 2872323
Placental and Fetal Effects of Onartuzumab, a Met/HGF Signaling Antagonist, When Administered to Pregnant Cynomolgus Monkeys PMID 29893934
EVIDENCE REQUIRED BY HEALTH TECHNOLGY ASSESSMENT AND REIMBURSEMENT BODIES EVALUATING DIAGNOSTIC OR PROGNOSTIC ALGORITHMS THAT INCLUDE OMICS DATA PMID 30136642
OA
The Expression of Anti
C22
MEIOK21 regulates oocyte quantity and quality via modulating meiotic recombination PMID 35593531
Targeting macrophage and microglia activation with colony stimulating factor 1 receptor inhibitor is an effective strategy to treat injury
[Simultaneous determination of five triterpenoid saponins in different parts of Aralia elata by high performance liquid chromatography
Fmoc
MCE
MCE
L
MCE
Dihydrofolate reductase (DHFR)激动剂、基因
MCE
Discovery of a Novel Oral Proteasome Inhibitor to Block NLRP3 Inflammasome Activation with Anti
Obudanersen (ION
MCE
Bafilomycins a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells PMID 2973058
3′
Potential of surface plasmon resonance biosensors in cancer detection PMID 33303267
Hypusine, a polyamine
Tricin 7
Fmoc
L
MCE
1,2
Nintedanib impurity 41 (Standard)
Protamine sulfate enhances lipid
FSG
6α
Dysfunction in Sertoli cells participates in glucocorticoid
3
程序性细胞死亡 5（PDCD5）基因
Orthosteric
Discovery of an MLLT1/3 YEATS Domain Chemical Probe PMID 30288907
5& 039;
Fmoc
5& 039;
10,10'
Losulazine 72141
Agonists with supraphysiological efficacy at the muscarinic M2 ACh receptor PMID 23062057
A double
Design and synthesis of a novel, achiral class of highly potent and selective, orally active neurokinin
Vitisin A Outperforms Cyanidin
Crosstalk between ST2 and TGF
c
Transcription Factor Activating Enhancer
Inhibition of androgen receptor promotes CXC
Sigma
Induction of CYP3A and associated terfenadine N
20
T
Il1rn Mouse Pre
Predictive three
New brefeldin A
Arylureas derived from colchicine Enhancement of colchicine oncogene downregulation activity PMID 29604583
Prodrugs of a 1
Propaquizafop 111479
Eimeria tenella IMP1 protein delivered by Lactococcus lactis induces immune responses against homologous challenge in chickens PMID 33248421
SU
Il1rn Rat Pre
Investigating the Therapeutic Efficacy of Quality
Discovery of Potent and Selective Phosphatidylinositol 3
TG693 885272
Phosphate dibasic
(+)
Skp2
CCG
CHERP Human Pre
U
Acantrifoic acid A 654663
Effects of LY267108, an erythromycin analogue derivative, on lower esophageal sphincter function in the cat PMID 8119532
immune
Treg
MCE
MCE
TACO1 Human Pre
PRLR Human Pre
CaV2.3
The Cyclopropyl Fragment is a Versatile Player that Frequently Appears in Preclinical/Clinical Drug Molecules PMID 27299736
MCE
A small
Cenpa Rat Pre
HBP1 Human Pre
Berberine ameliorates obesity by inducing GDF15 secretion by brown adipocytes PMID 36825874
Melatonin inhibits testosterone synthesis in Roosters Leydig cells by regulating lipolysis of lipid droplets PMID 35753225
Tetradecyltrimethylammonium chloride 4574
MCE
MCE
Potent preclinical activity of HexaBody
SB 207499 (Ariflo), a potent and selective second
marker
Dichlorodiphenylmethane 2051
3,5
赖氨酸脱甲基酶 4C（KDM4C）基因
ADI65533
SerBut 63321
Latest Developments in Insect Sex Pheromone Research and Its Application in Agricultural Pest Management PMID 34071020
monocytes
BRD4097 1550053
MCE
Neutrophil elastase induces inflammation and pain in mouse knee joints via activation of proteinase
Design, synthesis, and evaluation of cyclic C7
Clec10a
(E/Z)
An insight into the multifunctional role of ghrelin and structure activity relationship studies of ghrelin receptor ligands with clinical trials PMID 35344905
Design, synthesis, and biological evaluation of novel pyrido
Glutathione transferases
Natural angiotensin II type 1 receptor inhibitors Virtual screening and in vitro evaluation of beta
Immunodynamic axis of fibroblast
CP
Neutral biodegradable lipid
Zymosterone (酵母甾酮)
Identification of nicotinamide N
Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing PMID 21276940
MCE
Modeling human ectopic pregnancies with trophoblast and vascular organoids PMID 37224015
Intracerebroventricular infusion of the (Pro)renin receptor antagonist PRO20 attenuates deoxycorticosterone acetate
Noradrenalone impurity 1 hydrochloride 5090
FABP4 in macrophages facilitates obesity
Discovery of triazoloquinoxaline as novel STING agonists via structure
D3263
Carnosol as a Nrf2 Activator Improves Endothelial Barrier Function Through Antioxidative Mechanisms PMID 30781644
Aurora kinase
[D
Lanreotide 108736
NSC4959
A novel EGFR inhibitor acts as potent tool for hypoxia
Impact of whey protein hydrolysates on the formation of 2,5
Confirmation of the mapping of the Camurati
Discovery of GNE
Development of Ferrocenyl and Ruthenocenyl Zileuton Analogs with Enhanced Bioactivity toward Human 5
Diethylaminobenzaldehyde is a covalent, irreversible inactivator of ALDH7A1 PMID 25554827
Protective effects of berberine in a rat model of polycystic ovary syndrome mediated via the PI3K/AKT pathway PMID 33709493
Fmoc
SMARCB1 loss activates patient
MCE
Positive modulation of alpha
2
Black Phosphorus Nanosheets Grafted with Gold Nanorods and Carbon Nanodots for Synergistic Antitumor Therapy PMID 37232130
Transcriptomics reveals the underlying mechanism of Prostaglandin E1 in improving severe pneumonia PMID 40804382
3
Human Defensin
A prostaglandin J2 metabolite binds peroxisome proliferator
Design, synthesis, and biological evaluation of new 1,2,3
Peptide Aldehydes Incorporating Thiazol
Centrioles control the capacity, but not the specificity, of cytotoxic T cell killing PMID 32041868
New 1,4
BH3 相互作用域死亡激动因子（BID）基因
TTN
Dacemazine 518
3
Synthesis and activity of novel and selective I(Ks)
Bay 41
TGF
CB 3717 76849
RPW
Abcg2a is the functional homolog of human ABCG2 expressed at the zebrafish blood
HucMSC extracellular vesicles increasing SATB 1 to activate the Wnt/β
A phase I and pharmacokinetic study of 1843U89, a noncompetitive inhibitor of thymidylate synthase, in patients with advanced solid malignancies PMID 11448903
Fucoidan
Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules PMID 8087844
Optimization of the KK5 Scaffold and Biological Evaluation of KK5 Derivatives to Identify Potent Strigolactone Biosynthesis Inhibitors PMID 40480961
Inotodiol inhibits cells migration and invasion and induces apoptosis via p53
MAPK signalling
Discovery, optimization, and target identification of novel coumarin derivatives as HIV
Design, synthesis, and biological evaluation of novel, highly active soft ROCK inhibitors PMID 25898023
The updated evidence of pirfenidone treated silicosis based on network pharmacology, molecular docking and experimental validation PMID 40470053
Exchanging human Fcgamma1 with murine Fcgamma2a highly potentiates anti
MCE
Effects of 23
跨膜丝氨酸蛋白酶 2（TMPRSS2）基因
Alantolactone suppresses human osteosarcoma through the PI3K/AKT signaling pathway PMID 31974628
P2X7 receptor antagonist
Glucocorticoid
Protective effects of ACTH (4
MCE
Ajoene 92285
Atorvastatin lactone
矿物质代谢 (Mineral Metabolism)
Neuroprotection by the selective iNOS inhibitor GW274150 in a model of Parkinson disease PMID 21185368
L
Thiophene
MCE
Nitrogen
ALK
Apigenin Inhibits Histamine
Fmoc
VEGF121 蛋白, Human (HEK293)
Repetitive Transcranial Magnetic Stimulation Induces Cognitive Recovery in Alzheimer's Disease via GABAergic Neuron Activation of the Cx3cl1
MLN3126, an antagonist of the chemokine receptor CCR9, ameliorates inflammation in a T cell mediated mouse colitis model PMID 29730559
5'
Dendritic cell
MCE
Amitriptylinoxide 4317
MCE
Chlorquinaldol Alleviates Lung Fibrosis in Mice by Inhibiting Fibroblast Activation through Targeting Methionine Synthase Reductase PMID 39345816
WRN exonuclease imparts high fidelity on translesion synthesis by Y family DNA polymerases PMID 38503516
Functional Mechanism of MicroRNA
FGFR1/VEGFR2
Dentonin, a MEPE fragment, initiates pulp
Effects of a Novel Selective EP2 Receptor Agonist, Omidenepag Isopropyl, on Aqueous Humor Dynamics in Laser
Cardiovascular drugs. Dofetilide PMID 11085972
MCE
BP Fluor 405 alkyne triTEA 2006335
Risedronate prevents early radiation
p53 functional inhibitors behaving like pifithrin
turnover
T
4
Profiling of inhibitors of protein kinase C PMID 3250230
The Trace Amine
The regulation and function of CD20 an enigma of B
In vitro anti
Structure activity relationships of 5
Octyl salicylate a new contact sensitivity PMID 17177714
MCE
Dimemorfan phosphate 36304
1
Aaptamine derivatives from the Indonesian sponge Aaptos suberitoides PMID 23282083
Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti
[D
BMAL1 and ARNT enable circadian HIF2α responses in clear cell renal cell carcinoma PMID 40595592
Effects of quinone derivatives, such as 1,4
Sulfacarbamide 547
A network pharmacology
Timing of imaging after d
zinc
M30, a novel multifunctional neuroprotective drug with potent iron chelating and brain selective monoamine oxidase
β
Preclinical Profile of AB
Sodium selenite attenuates inflammatory response and oxidative stress injury by regulating the Nrf2/ARE pathway in contrast
Biodegradable and crosslinkable PPF
Discovery of a 2
Targeting PGAM1 in cancer An emerging therapeutic opportunity PMID 36215859
Alginate Oligosaccharide Prevents against D
Synthesis and biological activity of novel organoselenium derivatives targeting multiple kinases and capable of inhibiting cancer progression to metastases PMID 22204902
Potential Effects of CXCL9 and CCL20 on Cardiac Fibrosis in Patients with Myocardial Infarction and Isoproterenol
New drugs and technologies, intravenous anaesthesia is on the move (again) PMID 20650920
Ginsenoside Rh3
Quantitative NMR (qNMR) spectroscopy based investigation of the absolute content, stability and isomerization of 25
DP7
Differential effects of gamma
Ultrasound
phospholipid
Alpha
Diethylamino hydroxybenzoyl hexyl benzoate 302776
BL122
Enhanced expression of circular RNA hsa_circ_000984 promotes cells proliferation and metastasis in non
Specific binding of adamantane drugs and direction of their polar amines in the pore of the influenza M2 transmembrane domain in lipid bilayers and dodecylphosphocholine micelles determined by NMR spectroscopy PMID 21381693
Chinese herbal formula Regan Saibisitan alleviates airway inflammation of chronic bronchitis via inhibiting the JAK2/STAT3 pathway PMID 39788165
Enhanced ginsenoside productivity by combination of ethephon and methyl jasmoante in ginseng (Panax ginseng C.A. Meyer) adventitious root cultures PMID 16799761
Hypertension promotes bone loss and fragility by favoring bone resorption in mouse models PMID 40828611
Discovery of Pyridine
TRC150094, a novel functional analog of iodothyronines, reduces adiposity by increasing energy expenditure and fatty acid oxidation in rats receiving a high
HPV6
Effects of CdTe quantum dot exposure on the calcium signaling pathway in rat dorsal root ganglion cells ND7/23 PMID 40480474
p38 MAP Kinase Inhibitor III
Etalocib (Standard)
Design, synthesis, biological evaluation, and comparative docking study of 1,2,4
MCE
Coumaroyl flavonol glycosides from the leaves of Ginkgo biloba PMID 11738417
MCE
MCE
An exercise
MCE
2
CCR9
Analgesic effect of tianeptine in mice PMID 10227587
SLC7A1 Overexpression Is Involved in Energy Metabolism Reprogramming to Induce Tumor Progression in Epithelial Ovarian Cancer and Is Associated with Immune
HDAC4 induces the development of asthma by increasing Slug
Systematic identification of a synthetic lethal interaction in brain
MCE
Total Synthesis, Discovery and Biological Evaluation of Daldinin A Derivatives for Improving Hyperglycemia
Omigapil maleate 200189
Mucosal concentrations of N
Effect of subchronic exposure to tetradifon on bone remodelling and metabolism in female rat PMID 18068648
β
SARS
Aβ42
A Putative Zn2Cys6 Transcription Factor Is Associated With Isoprothiolane Resistance in Magnaporthe oryzae PMID 30429837
Discovery of novel multidrug resistance protein 4 (MRP4) inhibitors as active agents reducing resistance to anticancer drug 6
Z
MCE
Pharmacological PTP1B inhibition rescues motor learning, neuroinflammation, and hyperglycaemia in a mouse model of Alzheimer's disease PMID 39672227
共662页
首页
上一页
603
602
601
600
599
598
597
596
595
594
593
下一页
尾页
生物活性分子
ICP证:
粤ICP备2021105330号-3
联系人QQ：9145908
返回首页
RSS更新