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生物活性分子最近更新
[pTyr1146][pTyr1150][pTyr1151]Insulin Receptor (1142
CDK11A
Wnt5a/β
PRKCG 蛋白, Human (Active, sf9, GST)
NIM1K 蛋白,Human (Active, sf9, GST)
DBCO
2’
hBU 12
OP
EBOV entry
CGP 44 645
RPS6KB2/p70S6Kb
UTA1inh
Sotalol 3930
NSC
LY 254155
PRKCQ 蛋白, Human (sf9, GST)
CDK13
CP 376395 hydrochloride
2
Panobinostat lactate (Standard)
TMI
Valnivudine hydrochloride (FV
Decreased Expression of TGR5 in Vogt
HMS
8
BTK 蛋白, Human (Active, sf9, C
MBM
I3IN
Effect of estrogen inhibitors on conceptus estrogen synthesis and development in the gilt PMID 2013219
Quinidine hydrochloride monohydrate 6151
OL
Small molecule dual
S
N
COVID
Dipyrromethane
22 0 PC (1,2
TCA1
Guanidine
JPL
TBAJ
M2 Peptide
3,3',5,6,7,8
PRKCH/PKC eta
Fmoc
FKK6
ciliary processes
Kushenol M (苦参醇M)
C2
The role of glycosphingolipids in HIV/AIDS PMID 21524384
CAII
Antiproliferative Ability and Fluorescence Tracking of α
PAK4 蛋白, Human (GST)
Mel4
D
PAR4 antagonist 3
MmpL3
TXK
6
KLF 转录因子 4（KLF4）基因
Ketotrexate sodium (Emofolin sodium)
OYYF
AMG
Benzene
4
Design, synthesis, and biological evaluation of N
The flavonoid resokaempferol improves insulin secretion from healthy and dysfunctional pancreatic β
Identification of Nitric Oxide
Spatially
PRKCA 蛋白, Human (Active, sf9, GST)
20
Structure
APGA
Thiol
Tienilic acid (Ticrynafen，替宁酸)
Pathogenic microorganisms
AZ12672857
Gut microbiota dysbiosis exacerbates heart failure by the LPS
TCA1
UAMC
Hercynine (Histidine
DSHS00884 (SSYA10
Phenamet
(17S,18R)
IAP
MCE
Vitamin K distribution in rat tissues dietary phylloquinone is a source of tissue menaquinone
Discovery of Highly Potent and BMPR2
Aliphatic phenolic ethers from Trichobotrys effusa PMID 24797798
Anti
Insights into Triterpene Acids in Fermented Mycelia of Edible Fungus Poria cocos by a Comparative Study PMID 30987348
(R)
OSMI3
splicing
T lymphoblastic
Repaglinide M1
Modulation of CD44 Activity by A6
HY
Effect of efrotomycin in feed on the quantity, duration, and prevalence of shedding and antibacterial susceptibility of Salmonella typhimurium in experimentally infected swine PMID 3073676
Thalidomide
NH2
Ractopamine
Trt
Prostaglandin C2
Electrophysiologic, antiarrhythmic, and cardioprotective effects of N
Vitamin E
A 74704
Thalidomide
USP1
(S)
Ractopamine
BRD6257
GAC0003A4
Phytanic acid
13
Arachidic acid
Selective inhibition of Ph
The metabolomic profiling identifies N, N
SMAD specific E3 ubiquitin protein ligase 1 accelerates diabetic macular edema progression by WNT inhibitory factor 1 PMID 40093288
Irisflorentin improves functional recovery after spinal cord injury by protecting the blood
Biclotymol
ICA
Pomalidomide
PEG2
SID 26681509 quarterhydrate
Platelet
Color
Immunohistochemistry
Peritoneal GATA6+ macrophage drives hepatic immunopathogenesis and maintains the Treg cell niche in the liver PMID 35689656
Small
8
DF461
A core of kinase
Targeting the PDK/PDH axis to reverse metabolic abnormalities by structure
PHOP
ACE2
BTN3A1 Human Pre
Antifungal agent 151
3
JPL
耐多药
A C
Loss of Kmt2c / d promotes gastric cancer initiation and confers vulnerability to mTORC1 inhibition and anti
Hc
(E/Z)
(S)
OF
Risdiplam
FD
SUMO Protease
REDV TFA
P19As
2,4,5
Cbz
Cbz
2
Methotrexate analogues. 26. Inhibition of dihydrofolate reductase and folylpolyglutamate synthetase activity and in vitro tumor cell growth by methotrexate and aminopterin analogues containing a basic amino acid side chain PMID 2871191
Kirenol alleviates cerebral ischemia
Discovery of a novel, first
BMS
Hydroxy
Loureirin B Inhibits Hypertrophic Scar Formation via Inhibition of the TGF
Ochratoxin A and fumonisin B1 exhibit synergistic cytotoxic effects by inducing apoptosis on rat liver cells PMID 32325062
EPS15 蛋白, Human (His)
Pomalidomide
293T BRE
Neuropeptide FF (5
MCE
IGF
微珠聚集实验
AG
Design, synthesis and pharmacological evaluation of a novel mTOR
Hydroxy
Knockout and knockin of the beta1 exon D define distinct roles for integrin splice variants in heart function and embryonic development PMID 9553049
Isobutanoic acid
鳞状细胞癌 (Squamous Cell Carcinoma)
(+)
MCE
PKMYT1
RSK3/RPS6KA1
MCE
Small
HKOCl
PLAU/uPA 蛋白, Human (HEK293, His)
PAK降解剂、基因
ent
Ethyl 7
Design and synthesis of lipophilic phosphoramidate d4T
C 端结合蛋白 1（CTBP1）基因
Capsazepine, a TRPV1 antagonist, sensitizes colorectal cancer cells to apoptosis by TRAIL through ROS
Inhibitory effects of polyphenols toward HCV from the mangrove plant Excoecaria agallocha L PMID 22196120
IAP
Periplocin ameliorates mouse age
Talopram hydrochloride
Bosutinib high density lipoprotein nanoformulation has potent tumour radiosensitisation effects PMID 36945003
Agonism of CD11b reprograms innate immunity to sensitize pancreatic cancer to immunotherapies PMID 31270275
Asciminib
A new antibiotic XK
Methoxatin (PQQ) in guinea
SH
eIF2B activator prevents neurological defects caused by a chronic integrated stress response PMID 30624206
Boc
Pomalidomide
THP
m
SPRT
Hydroxy
13(S)
HKI12134085
2
1
Substrate
leaf algae
血原（HEMGN）基因
RG7800 (Standard) (RO6885247 (Standard))
SKI
配体依赖性核受体辅阻遏物（LCORL）基因
Hydrocinnamic acid
AT1412 (AT14
Dexamethasone phosphate
Propargyl
S
CHS
KR
4
Hypoxia
Rapamycin ameliorates chronic intermittent hypoxia and sleep deprivation
3
7
(S)
Methyl 3(R,S)
Hydrogen alleviates impaired lung epithelial barrier in acute respiratory distress syndrome via inhibiting Drp1
L
4
Tumor Angiogenic Inhibition Triggered Necrosis (TAITN) in Oral Cancer PMID 31336612
Design and Characterization of a Novel Venetoclax
Hydrocinnamic acid
Inhibition of HCN channels decreases motivation for alcohol and deprivation
Hydrocinnamic acid
2
3
STING Agonist
DNAJC12 downregulation induces neuroblastoma progression via increased histone H4K5 lactylation PMID 39716470
Bombolitin I
N
4
L
DOPE
2,4
Spry1 Mouse Pre
Eriodictyol 7
Fraxinol (白蜡树精)
UNC
PRKCI 蛋白, Human (sf9, His)
L1CAM mimetic compound duloxetine improves cognitive impairment in 5xFAD mice and protects Aβ1
Maltol inhibits apoptosis of human neuroblastoma cells induced by hydrogen peroxide PMID 16584628
Deficiency in peptidoglycan recycling promotes β
微自噬
MCE
Tienilic acid (Standard) (Ticrynafen (Standard)，替宁酸 (标准品))
Chemerin
TNIK/ZC2
PINK1 ameliorates acute
Dinor
P19P
PAK7/PAK5
(S)
Fraxinol (Standard) (白蜡树精 (Standard))
Raf
ARN726
USP20/Ub
Levalbuterol ((R)
Fpr2 Mouse Pre
PAK3 蛋白, Human (sf9)
Platycodin D Enhances Glioma Sensitivity to Temozolomide by Inhibition of the Wnt/β
Inhibition of microRNA
Efficient generation of a CYP3A4
IDF
泛素特异肽酶 48 (Ubiquitin specific peptidase 48 (USP48))
Eicosapentaenoic acid restores inflammation
Tissue
ARN14974
Substrate
Azido
Cap 2
维生素 B9
JNK
Effect of cysteamine on glutathione level and developmental capacity of bovine oocyte matured in vitro PMID 8607972
补充 C8 伽马链（C8G）基因
Antibacterial agent 315
C2
β
Gentamicin C2
MAP3K4 蛋白, Human (sf9, His, GST)
GNE
N
HR97 TFA
cognitive dysfunction
Ciapavir (SBI
Dupracetam
The perinuclear theca protein Calicin helps shape the sperm head and maintain the nuclear structure in mice PMID 35793634
5
In vitro activities of posaconazole, fluconazole, itraconazole, voriconazole, and amphotericin B against a large collection of clinically important molds and yeasts PMID 16723559
Nepaprazole (rel
Elranatamab (PF
CDD
MiR
O
LY
Bis
Substrate
CYP24A1 inhibition enhances the antitumor activity of calcitriol PMID 20591973
BMS
ITRI
PEG2000
Lithium citrate tetrahydrate (Litarex tetrahydrate，柠檬酸三锂盐四水合物)
3,6,9
Targeting Acyl
AP232 dihydrochloride
Ferruginol Diterpenoid Selectively Inhibits Human Thyroid Cancer Growth by Inducing Mitochondrial Dependent Apoptosis, Endogenous Reactive Oxygen Species (ROS) Production, Mitochondrial Membrane Potential Loss and Suppression of Mitogen
Hypoxanthine
3
Fpr2
2
4
Biosynthesis of napyradiomycins PMID 3429338
(S)
SPRT
Oe
IZ
(4E)
factor IX
TRPC1 contributes to endotoxemia
4
dysfunctional
Pyripyropene A, an acyl
The cholesterol esterification inhibitor avasimibe suppresses tumour proliferation and metastasis via the E2F
DSPE
FAPI
4
Ephb1
Mesenchymal
modulator
Substrate
Boc
7
3’
Antiviral agent 52
CSF1R
Cbz
CRF1 receptor signaling regulates food and fluid intake in the drinking
Geiparvarin Inhibits the Progression of Osteosarcoma by Down
NBD
Associations between isoflavone exposure and reproductive damage in adult males evidence from human and model system studies PMID 35948002
Design, Synthesis, Biological Evaluation, and Computational Studies of Novel Ureidopropanamides as Formyl Peptide Receptor 2 (FPR2) Agonists to Target the Resolution of Inflammation in Central Nervous System Disorders PMID 35257581
TCL065
Melatonin potentiates the cytotoxic effect of Neratinib in HER2+ breast cancer through promoting endocytosis and lysosomal degradation of HER2 PMID 34556812
FD895
Discovery of cyclic amine
(
CB
Milk exosomes with enhanced mucus penetrability for oral delivery of siRNA PMID 33367332
Methyl betulonate (Betulonic acid methyl ester)
Analysis of single
PEG4
STAT3 ameliorates cognitive deficits by positively regulating the expression of NMDARs in a mouse model of FTDP
Cyclic peptides from higher plants. XXVIII. Antitumor activity and hepatic microsomal biotransformation of cyclic pentapeptides, astins, from Aster tataricus PMID 8689717
2’
Bicyclol ameliorates nonalcoholic fatty liver disease in mice via inhibiting MAPKs and NF
The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome PMID 27076076
基底样乳腺癌 (BLBC)
CD9 分子（CD9）基因
淀粉样蛋白前体蛋白结合家族 B 成员 2（APBB2）基因
Substrate stiffness regulates the differentiation profile and functions of osteoclasts via cytoskeletal arrangement PMID 34953003
SHC 衔接蛋白 1（SHC1）基因
In vitro generation of neuraminidase inhibitor resistance in A(H5N1) influenza viruses PMID 19651908
Acid
DSPE
C13
C2
FR
Arachidic acid
Ro 01
热休克蛋白 90 α 家族 B 类成员 1（HSP90AB1）基因
num
FPR2 agonist 2 2829263
cell
81576
BI
Integrated multi
脓毒症 1（SEPTIN1）基因
2
Glycocholic Acid
Peplomycin sulfate (Bleomycin PEP sulfate)
Rosmarinic Acid Inhibits Platelet Aggregation and Neointimal Hyperplasia In Vivo and Vascular Smooth Muscle Cell Dedifferentiation, Proliferation, and Migration In Vitro via Activation of the Keap1
Pyk2/MCU Pathway as a New Target for Reversing Atherosclerosis PMID 34026753
MSDC
转化生长因子β1（TGFB1）基因
Trpv3
含富亮氨酸的重复序列和 Ig 结构域 1（LINGO1）基因
5
Risdiplam distributes and increases SMN protein in both the central nervous system and peripheral organs PMID 30519476
张力蛋白 3（TNS3）基因
TYRO3/DTK 蛋白, Human (Q261H, HEK293, Fc)
THZ1
Salicyluric acid
中链脂肪酸
ocular inserts
MDA
Mechanisms of readthrough mitigation reveal principles of GCN1
IN04
Fluorescently labeled analogues of dofetilide as high
无名指蛋白 135（RNF135）基因
AT 钩转录因子（AKNA）基因
液泡蛋白分选 72 同系物（VPS72）基因
NADH：泛醌氧化还原酶亚基 A7（NDUFA7）基因
线粒体核糖体蛋白 L12（MRPL12）基因
7637
皮层蛋白结合蛋白 2（CTTNBP2）基因
FBXO28
serpin 家族 F 成员 2（SERPINF2）基因
BMS
BODIPY FL C5
LEB
Discovery of O
AG
LY
DMU759
KI
驱动蛋白家族成员 9（KIF9）基因
Discovery of a Potent and Selective Targeted NSD2 Degrader for the Reduction of H3K36me2 PMID 36976643
冠宁 1A（CORO1A）基因
脾相关酪氨酸激酶（SYK）基因
TANDEM (Des
MCE
Potent Inhibitors Active against HIV Reverse Transcriptase with K101P, a Mutation Conferring Rilpivirine Resistance PMID 26487915
SAP1
Probenecid novel use as a non
Small
Emixustat
protein
Seletracetam enhances short term depression in vitro PMID 26320080
Anti
CDK17
Sudemycin D6
Chlorophyll c2 (Chlorophyllide c2)
T 588
NS163
KB05yne
姐妹染色单体内聚力的建立 N
甲硫氨酸亚砜还原酶 B3（MSRB3）基因
interactor
L
FAPI
Human Factor IX (人凝血因子IX)
2
Enzymatic independent role of sphingosine kinase 2 in regulating the expression of type I interferon during influenza A virus infection PMID 36070294
瞬时受体电位阳离子通道亚家族 V 成员 3（TRPV3）基因
Isolation, structures, and structure
9A1P9
Nusap1 Mouse Pre
Quinfamide (WIN
Sigma
Benzo
含锚蛋白重复序列和无菌 alpha 基序结构域 1A（ANKS1A）基因
TOP1288
UFM1 特异性肽酶 2（UFSP2）基因
具有 LIM 结构域的锌指蛋白 185（ZNF185）基因
细胞周期蛋白和 CBS 结构域二价金属阳离子转运介质 1（CNNM1）基因
structured RNA
含 C 的 IQ 基序（IQCC）基因
立即早期反应 2（IER2）基因
组蛋白 H3 相关蛋白激酶（HASPIN）基因
Diclofenac impurity 9
CD276 分子（CD276）基因
SRY
29070
Serpinf2 Mouse Pre
kelch 样家族成员 9（KLHL9）基因
异质核核糖核蛋白 H2（HNRNPH2）基因
RNA 聚合酶线粒体（POLRMT）基因
转化生长因子β受体 3（TGFBR3）基因
连环蛋白 alpha like 1（CTNNAL1）基因
kelch 样家族成员 13（KLHL13）基因
Identification and characterization of small molecule modulators of the Epstein
T 细胞激活 RhoGTPase 激活蛋白（TAGAP）基因
MicroRNA modulator
FPR2 agonist 3 2829263
NMDA receptor antagonist 7
CD3E
含 SH2 结构域 4A（SH2D4A）基因
磷酸肌醇 3 激酶调节亚基 2（PIK3R2）基因
Ras 2 激酶抑制因子的连接增强子（CNKSR2）基因
Trapoxin A Analogue as a Selective Nanomolar Inhibitor of HDAC11 PMID 36977486
MMP
DNA 聚合酶 alpha 2，辅助亚基（POLA2）基因
钙结合和卷曲螺旋结构域 2（CALCOCO2）基因
NUT 中线癌家族成员 1（NUTM1）基因
泛素结合酶 E2 U（UBE2U）基因
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