最近收录_第486页_生物活性分子
生物活性分子最近更新
Picrotin 21416
LIM 同源框转录因子 1 beta（LMX1B）基因
Chloroquine and hydroxychloroquine as available weapons to fight COVID
Subtle Structural Modifications Spanning from EP4 Antagonism to EP2/EP4 Dual Antagonism A Novel Class of Thienocyclic
Dual inhibition of EGR1/STAT3 transcriptional hubs suppresses macrophage
Olive oil (Cropure OL，橄榄油)
Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX
Albanin A, Derived from the Root Bark of Morus alba L., Depresses Glutamate Release in the Rat Cerebrocortical Nerve Terminals via Ca2+/Calmodulin/Adenylate Cyclase 1 Suppression PMID 33739887
PARP
BB 0305179
GSK
Effect of budesonide and azelastine on histamine signaling regulation in human nasal epithelial cells PMID 27623823
Hydroxysafflor yellow A 78281
Panepophenanthrin 409064
The RNA
VCPA, a novel synthetic derivative of α
Cox B
Synthesis and antibacterial activity of novel benzodioxin
Effects of doxapram on ionic currents recorded in isolated type I cells of the neonatal rat carotid body PMID 1667613
cis
SARS
Platelet
Bioinformatic analysis linking genomic defects to chemosensitivity and mechanism of action PMID 33909629
LASP1 蛋白, Human (His)
Trametinib (DMSO solvate)
Z
Repurposing HIV protease inhibitors as senotherapeutic agents in cervical cancer Dual targeting of CDK1/6
N6
Pyruvate Kinase M2
Akt inhibitor MK
Avibactam potentiated the activity of both ceftazidime and aztreonam against S. maltophilia clinical isolates in vitro PMID 33618662
Low
IFN
Ldb1 Mouse Pre
Small
2
1
Wuliangye Baijiu but not ethanol reduces cardiovascular disease risks in a zebrafish thrombosis model PMID 36470888
AT
An Isofibrous Diet with Fiber Konjac Glucomannan Ameliorates Salmonella typhimurium
Laduviglusib 252917
Nosiheptide 56377
CD44 expression on activated B cells. Differential capacity for CD44
CD27 分子（CD27）基因
Top Publications Citing MCE Products
Epothilone B 152044
Nivolumab
Xiezhuo Tiaozhi formula inhibits macrophage pyroptosis in the non
Tumor Genotype Dictates Mitochondrial and Immune Vulnerabilities in Liver Cancer PMID 40964275
CD4 蛋白, Human (HEK293, Fc)
ER
Chlorhexidine dihydrochloride 3697
CEA 细胞粘附分子 8（CEACAM8）基因
MEK
(Rac)
Exploring the PROTAC degron candidates OBHSA with different side chains as novel selective estrogen receptor degraders (SERDs) PMID 30939353
Gentiopicroside inhibits retinoblastoma cell proliferation, invasion, and tumorigenesis in nude mice by suppressing the PI3K/AKT pathway PMID 37555853
Methamphetamine ethyl carbamate 120504
Quercetin 3
USP5 facilitates diabetic retinopathy development by stabilizing ROBO4 via deubiquitination PMID 38735506
Transketolase drives the development of aortic dissection by impairing mitochondrial bioenergetics PMID 38380737
CART (55
Vulnerability of drug
DC 1630423
Enhanced cAMP protein kinase A signaling determines improved insulin secretion in a clonal insulin
Pharmacological analysis of cyclooxygenase
EXOSC8 promotes colorectal cancer tumorigenesis via regulating ribosome biogenesis
Streptococcus Suis Serotype 2 Stimulates Neutrophil Extracellular Traps Formation via Activation of p38 MAPK and ERK1/2 PMID 30581435
5'
GSTP1 Human Pre
Antibody
(4S)
brain?infarct
ROS
Niclofolan (BAY 9015)
Idalopirdine hydrochloride 467458
Aggravation of hepatic ischemia‑reperfusion injury with increased inflammatory cell infiltration is associated with the TGF‑β/Smad3 signaling pathway PMID 34132369
A novel cecropin B
Design and synthesis of naphthalenic dimers as selective MT1 melatoninergic ligands PMID 12646022
L
Adrenosterone
Ritonavir
In vitro activity of pyrimethamine, cycloguanil, and other antimalarial drugs against African isolates and clones of Plasmodium falciparum PMID 8116812
Solid
LMW peptide
Exploiting the Evolutionary Relationship between Malarial Parasites and Plants To Develop New Herbicides PMID 28654179
Selective Inhibition of Human Monoamine Oxidase B by Acacetin 7
叶绿醌
Glu
Nicaraven (烟拉文)
Nuvenzepine
4
Lkb1 orchestrates γδ T
DARS2 promotes the occurrence of lung adenocarcinoma via the ERK/c
Egg phosphatidylcholine decreases the lymphatic absorption of cholesterol in rats PMID 11533279
Synthesis, structure elucidation, DNA
Maintenance of MYC expression promotes de novo resistance to BET bromodomain inhibition in castration
The vasorelaxant effect of evocarpine in isolated aortic strips mode of action PMID 2854068
Acyl
KDM5
IL
Development of a Physiologically Based Pharmacokinetic Model for Sinogliatin, a First
MC
Hand
Prkg1 Rat Pre
Neuroprotective effects of a novel poly (ADP
IRL
NAT10 promotes gastric cancer progression by enhancing the N4
Chemotherapy Enriches for Proinflammatory Macrophage Phenotypes that Support Cancer Stem
Aloperine improves osteoporosis in ovariectomized mice by inhibiting RANKL
Integrated Virtual Screening Approach Identifies New CYP19A1 Inhibitors PMID 40106333
蛋白激酶 AMP 激活的催化亚基 alpha 1（PRKAA1）基因
PROTAC FLT
12
Plant nucleoside N
Smurf1 and Smurf2 mediated polyubiquitination and degradation of RNF220 suppresses Shh
Podocyte SIRPα reduction in diabetic nephropathy aggravates podocyte injury by promoting pyruvate kinase M2 nuclear translocation PMID 39586122
Magnesium sulfate heptahydrate, United States Pharmacopeia (USP) Reference Standard
Involvement of serotonin 2C receptor RNA editing in accumbal neuropeptide Y expression and behavioural despair PMID 26950265
骨形态发生蛋白 4（BMP4）基因
Dietary Zinc activates the Nrf2 signaling pathway to inhibit pyroptosis and attenuate the lung inflammatory response in COPD PMID 39980839
AZD
Cd5 Rat Pre
The small molecule '1
Pindolol 13523
ALDH6A1 weakens the progression of colon cancer via modulating the RAS/RAF/MEK/ERK pathway in cancer cell lines PMID 35907565
TMPRSS2
Flupirtine 56995
R 348
Potassium hydrogen phthalate 877
Vital role of Autophagy flux inhibition of placental trophoblast cells in pregnancy disorders induced by HEV infection PMID 37882369
(E)
The monoamine oxidase inhibitor
Magnesium sulfate heptahydrate, United States Pharmacopeia (USP) Reference Standard
Antibiotic metabolite of a fungus cultivated by gardening ants PMID 575666
R 348
AZD
JTT130
TMPRSS2
Targeting PPARα activation sensitizes glioblastoma cells to temozolomide and reverses acquired resistance by inhibiting H3K18 lactylation PMID 40500345
toll 样受体 1（TLR1）基因
脯氨酰 3
Evaluation and mechanism of immune enhancement effects of Pleurotus ferulae polysaccharides
JTT130
Brompheniramine maleate 980
CD89 抗体 (YA1960)（CD89 Antibody (YA1960)）
2,4
Chebulinic acid 18942
Cholic acid sodium 361
E,E
PiRNA
The formation of 2
A high
Estradiol benzoate 50
Synthesis, characterization and structure
DNA Gyrase
4(15),11
P2Y14 antagonist 1
Desloratadine
3
Clopidogrel carboxylic acid
Oxyphenisatin acetate 115
Nrf2 in keratinocytes protects against skin fibrosis via regulating epidermal lesion and inflammatory response PMID 32032580
Top Publications Citing MCE Products
Alisol A Suppresses Proliferation, Migration, and Invasion in Human Breast Cancer MDA
Discovery of Narlaprevir (SCH 900518) A Potent, Second Generation HCV NS3 Serine Protease Inhibitor PMID 24900178
Strategies for Precise Engineering and Conjugation of Antibody Targeted
Jingzhaotoxin
Synthesis and Pharmacological Evaluation of 1
Tiger17 1647121
Isoamyl butyrate 106
Higenamine hydrochloride 11041
RIFM fragrance ingredient safety assessment, 1,2
E2F2 induces microglial activation and augments depressive
CD14 分子（CD14）基因
2
APX
Anti
pleiotropic
Bis(benzonitrile)palladium chloride 14220
pleiotropic
APX
Estrone 3
Colon Cancer
Ketamine Alleviates Fear Generalization Through GluN2B
Plasma
4
质谱氢/氘交换研究
VPS13B Human Pre
Differential effects of kinase cascade inhibitors on neoplastic and cytokine
Cyclo(Ile
HDAC5 integrates ER stress and fasting signals to regulate hepatic fatty acid oxidation PMID 29229738
Elacestrant 722533
Time
Lmo2
A rationally designed self
The IL
FAK
Investigation of metabolic stability of the novel ALK inhibitor brigatinib by liquid chromatography tandem mass spectrometry PMID 29458050
polyp
Icariin promotes mouse Leydig cell testosterone synthesis via the Esr1/Src/Akt/Creb/Sf
Ameliorative effect of SIRT1 in postpartum depression mediated by upregulation of the glucocorticoid receptor PMID 34265417
ACT001 inhibits the proliferation of non
Activation of TLR7
YCT529
H19 promotes polarization and alternative splicing in tumor
Chronic kidney disease promotes cerebral microhemorrhage formation PMID 36841828
Exploring the mechanism by which quercetin re
Seladelpar sodium salt 3026272
Urotensin II, teleost fish 9047
Discovery of new non
Connexin32 promotes the activation of Foxo3a to ameliorate diabetic nephropathy via inhibiting the polyubiquitination and degradation of Sirt1 PMID 36601735
Licoflavanone (3′
Modular cell
Resistance to anti
RANKL/TNFSF11 蛋白, Human (HEK293, His
Microcystin
trans
Discovery of a Small
CARM1 degrader
Swinglea glutinosa (Blanco) Merr.提取物 (Swinglea glutinosa (Blanco) Merr.)
Quadruple synergistic amplification of ferroptosis for precision glioblastoma therapy a luteolin
磷酸二羟丙酮
Preparation of przewalskinic acid A from salvianolic acid B using a crude enzyme from an Aspergillus oryzae strain PMID 24615145
Acute Heat Stress Leads to Reversible Aggregation of Nuclear Proteins into Nucleolar Rings in Fission Yeast PMID 33176152
Xanthine amine congener hydrochloride 1783977
CD47
Lactate transportor 1
MircoRNA
Participation of the inositol 1,4,5
A chemical genetics approach identifies PTP4A3 as a regulator of colon cancer cell adhesion PMID 29746167
Melatonin alleviates lead
Halogenated class of oximes as a new class of monoamine oxidase
Aggreceride C 104700
沉默信息调节因子 2 相关酶类 5（Sirt5）基因
Emirodatamab 2449199
Discovery of a small
Broad antitumor activity in breast cancer xenografts by motesanib, a highly selective, oral inhibitor of vascular endothelial growth factor, platelet
VAV2 is required for DNA repair and implicated in cancer radiotherapy resistance PMID 34462423
Cholinergic signaling of muscarinic receptors directly involves in the neuroprotection of muscone by inducing Ca2+ antagonism and maintaining mitochondrial function PMID 37734472
CpG
10
Filgotinib 1206161
Long non
(2S)
Levetiracetam induction of theta frequency oscillations in rodent hippocampus in vitro PMID 32516556
Comprehensive Surfaceome Profiling to Identify and Validate Novel Cell
1
trans
Octisalate
Gut fungi enhances immunosuppressive function of myeloid
Ribosome formation is blocked by camptothecin, a reversible inhibitor of RNA synthesis PMID 5289246
Palonosetron exhibits unique molecular interactions with the 5
GDC
Synthesis of 2
NODAGA
Network analysis of α
Didemnin B induces cell death by apoptosis the fastest induction of apoptosis ever described PMID 7488040
[cPP1
Synthesis and structure
LysoPE(0 0/18 2)
TRIB1 Human Pre
PROTAC SMARCA2/4
KDU731
Krypton Fluoride Preparation by the Matrix Isolation Technique PMID 17836480
10(Z)
4,6
S/GSK1349572
absorption
Comparison of the anti
prostate cancer.
Ligands for glutamate receptors design and therapeutic prospects PMID 10893301
Transforming Myofibroblasts Into Lipid
Naftopidil
Pyrvinium pamoate regulates MGMT expression through suppressing the Wnt/β
CRF, bovine 92307
A chromophoric and fluorescent analog of GTP, 2',3'
Octyl glucose neopentyl glycol 1257853
P
IDUA Human Pre
Integrin αVβ1
CTLA
Early phase 2 trial of TAS
氧化环苯扎林N氧化物
Extracellular regulation of VEGF isoforms, proteolysis, and vascular patterning PMID 24332926
Glucocorticoid Receptor
Antiplasmodial and antitumor activity of dihydroartemisinin analogs derived via the aza
Targeting BCR
Emtricitabine triphosphate in dried blood spots is a predictor of viral suppression in HIV infection and reflects short
Chromatin architecture protein HMGA2 promotes glioma malignancy via novel mechanism of IGFBP3 transcription inhibition PMID 40450974
T follicular helper expansion and humoral
Oxidative Phosphorylation
DGKα/ζ inhibitors combine with PD
Noxiustoxin 85205
Triterpenoids from Dysoxylum malabaricum PMID 11249096
Attenuated expression of SNF5 facilitates progression of bladder cancer via STAT3 activation PMID 34876150
Design and Characterization of SGK3
Dabigatran etexilate activation is affected by the CES1 genetic polymorphism G143E (rs71647871) and gender PMID 27614009
环状 GMP
Simvastatin acid 121009
Lamotrigine
2
Comparative study of the inhibitory effect of antidepressants on cholinesterase activity in Bungarus sindanus (krait) venom, human serum and rat striatum PMID 18608756
behaviors
Structure
Hepatitis B virus hijacks MRE11
Towards small molecule inhibitors of mono
Cd5 Mouse Pre
Design and synthesis of imidazo[2,1
Metabolic Control of Astrocyte Pathogenic Activity via cPLA2
Tamapin TFA
Inhibition of P2X7R in the amygdala ameliorates symptoms of neuropathic pain after spared nerve injury in rats PMID 32311494
HIF1α Regulates IL17 Signaling Pathway Influencing Sensitivity of Taxane
Hydrolyzed conchiolin protein inhibits melanogenesis through PKA/CREB and MEK/ERK signalling pathways PMID 39128885
Synergistic effects of curcumin and its analogs with other bioactive compounds A comprehensive review PMID 33310285
Inhibition of DDR1 potentiates carbon ion radiotherapy by promoting ferroptosis and immunogenic death in head and neck squamous cell carcinoma PMID 40993737
CXCL8 promotes the invasion of human osteosarcoma cells by regulation of PI3K/Akt signaling pathway PMID 28736978
Inhibition of interleukin
Transketolase
(2E,15Z,18Z,21Z,24Z,27Z)
EphrinB2/ephB2 activation facilitates colonic synaptic potentiation and plasticity contributing to long
Nicotine Reprograms Aging
泛素结合酶 E2 Z（UBE2Z）基因
Thalidomide
11
Cyclobutyrol 512
FB231
A Novel Theranostic Strategy for Malignant Pulmonary Nodules by Targeted CECAM6 with 89Zr/131I
Controlling mitochondrial membrane architecture via MIC60 determines viral replication to promote anti
VDAC诱导剂、基因
Synthesis of novel guttiferone E and xanthochymol derivatives with cytotoxicities by inducing cell apoptosis and arresting the cell cycle phase PMID 30500683
ST
Ofloxacin
Innovative peptide therapeutics targeting IL17RA to regulate inflammatory responses PMID 40121226
MiR
N
Pharmacologic inhibition of eIF4A blocks NRF2 synthesis to prevent osteosarcoma metastasis PMID 39078310
3
Pterostilbene suppresses oxidative stress and allergic airway inflammation through AMPK/Sirt1 and Nrf2/HO
Nesfrotamig 2966936
EO 1428
Ocarocoxib 215122
mesenchymal
Label
Cytotoxic activity of the MK2 inhibitor CMPD1 in glioblastoma cells is independent of MK2 PMID 27551460
Mitozolomide 85622
KPT
Herniarin 531
JMV 2959
Candenatenins A
Chronic myeloid leukemia the paradigm of targeting oncogenic tyrosine kinase signaling and counteracting resistance for successful cancer therapy PMID 29455643
Ultrasound
The effects of 6
CSF
Isorhamnetin Ameliorates Aspergillus fumigatus Keratitis by Reducing Fungal Load, Inhibiting Pattern
Furprofen 66318
Discovery and characterization of novel inhibitors of the sodium
EMD
ASLAN 003
SKLB70326, a novel small
2
Immunotherapy of hay fever with ragweed antigen E comparisons with whole pollen extract and placebos PMID 4873833
PK11007 Covalently Inhibits Thioredoxin Reductase 1 to Induce Oxidative Stress and Autophagy Impairment in NSCLC Cells PMID 41154531
Elevated type I IFN signalling directly affects CD8+ T
Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase PMID 27547922
Sulforaphane Inhibits LPS
Glycosphingolipids are linked to elevated neurotransmission and neurodegeneration in a Drosophila model of Niemann Pick type C PMID 37815467
双特异性酪氨酸
Endothelial leakiness elicited by amyloid protein aggregation PMID 38242873
Unraveling the association and regulatory role of miR
Alpinoid D 1041740
Depot
Metolachlor stereoisomers Enantioseparation, identification and chiral stability PMID 27544750
Arg
GW405833 hydrochloride 1202865
The H3 antagonist, ciproxifan, alleviates the memory impairment but enhances the motor effects of MK
Forskolin modifies retinal vascular development in Mrp4
WAY
Exploring the tetrahydroisoquinoline thiohydantoin scaffold blockade the androgen receptor as potent anti
SGK1 aggravates idiopathic pulmonary fibrosis by triggering H3k27ac
TBC3711
ME 401
BCR
Therapeutic targeting of SLC6A8 creatine transporter suppresses colon cancer progression and modulates human creatine levels PMID 34613776
Modulation of lipid kinase PI4KIIα activity and lipid raft association of presenilin 1 underlies γ
DCIP sodium
Nrf2
7
N
A facile consensus ranking approach enhances virtual screening robustness and identifies a cell
BAAT Human Pre
Gestational exposure to nanoplastics disrupts fetal development by promoting the placental aging via ferroptosis of syncytiotrophoblast PMID 40080956
Combination therapy enhances the inhibition of tumor growth with the fully human anti
Deficiency of aldehyde dehydrogenase 2 aggravates ethanol
Comparison of two bowel preparations for colonoscopy sodium picosulphate with magnesium citrate versus sulphate
SESN2 maintains cartilage homeostasis by SREBP1
Bcl
m
Schisanlignone C 144606
Synthesis and evaluation of 2
TRAF7 inhibits proliferation and migration of esophageal squamous cell carcinoma by ubiquitination
尿苷
Novel inhibitors of carboxypeptidase G2 (CPG2) potential use in antibody
30
吡咯喹啉醌二钠盐
osmotic
RLX hydrochloride (PD 139530 hydrochloride)
Zolpidem phenyl
pharmaceutical auxiliarie
罗伐他汀钙
Blockade of the lncRNA
Double prodrugs of a fosmidomycin surrogate as antimalarial and antitubercular agents PMID 30879839
DNA 损伤反应
In vitro activity of naftifine, a new antifungal agent PMID 7247366
Hyaluronic acid a natural biopolymer with a broad range of biomedical and industrial applications PMID 17091377
Artemisinin resistance
Quercetin attenuates the proliferation of arsenic
SIRT4 prevents excitotoxicity via modulating glutamate metabolism in glioma cells PMID 32081049
Emerging Anticancer Activity of Candidal Glucoseamine
Ibrexafungerp An orally active β
Iberverin exhibits antineoplastic activities against human hepatocellular carcinoma via DNA damage
T
Nilotinib hydrochloride 923288
Severe inflammation in new
Lucidone suppresses hepatitis C virus replication by Nrf2
Differential Bioactivation Profiles of Different GS
FATS alleviates ulcerative colitis by inhibiting M1 macrophage polarization and aerobic glycolysis through promoting the ubiquitination
Targeting crosstalk of STAT3 between tumor
Calcium/calmodulin
mood
Dehydronitrosonisoldipine 87375
2,6
Kinsenoside ameliorates intervertebral disc degeneration through the activation of AKT
Q134R 2022949
GAL3ST4 Human Pre
BCL3
JNJ
Evaluation of Benzothiazole
Carboxyamidotriazole Synergizes with Sorafenib to Combat Non
GZD 824
Synthesis of novel 3,5,6
Pretreatment with chitosan oligosaccharides attenuate experimental severe acute pancreatitis via inhibiting oxidative stress and modulating intestinal homeostasis PMID 33495520
Establishment and Use of Human Mouth Epidermal Carcinoma (KB) Cells Overexpressing P
吡格列酮钾盐
Design, Synthesis, and Antiplasmodial Activity of Hybrid Compounds Based on (2R,3S)
G9D
Chinese medicine compound prescription HeQi San ameliorates chronic inflammatory states and modulates gut flora in dehydroepiandrosterone
Docking model of drug binding to the human ether
Thermolysin, Bacillus thermoproteolyticus rokko 9073
NSC 369397
Lamotrigine
NSC348884, a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis in human cancer cells PMID 18345031
Discovery of quinazolines as a novel structural class of potent inhibitors of NF
Accelerated plasma
Neolinine 112515
Baat Rat Pre
KIRA
Generation of vascularized human cardiac organoids for 3D in vitro modeling PMID 37384522
Aspartyl proteases in Candida glabrata are required for suppression of the host innate immune response PMID 29491142
Bizelesin 129655
2
SP2
Replacement of proteasome subunits X and Y by LMP7 and LMP2 induced by interferon
mantle cell lymphoma
PPIase
Ldb1 Rat Pre
Erythrocytes as carriers for L
broad spectrum
JMS
A CD1d
Neuromedin U and its receptors structure, function, and physiological roles PMID 15169928
Thalidomide
SU11274 (PKI
NGFR 蛋白, Human (HEK293)
Cacna1d
Fluoroalkene modification of mercaptoacetamide
Guggulsterone inhibits migration and invasion through proteasomal and lysosomal degradation in human glioblastoma cells PMID 36436590
Development of the first non
Role of Transcription Factor Nrf2 in Pyroptosis in Spinal Cord Injury by Regulating GSDMD PMID 36040608
Butyraldehyde 2,4
P300/SP1 complex mediating elevated METTL1 regulates CDK14 mRNA stability via internal m7G modification in CRPC PMID 37599359
4
peripheral B
N
Putrescine (1,4
Akt1
6
SDC1
Clemastine Inhibits the Biofilm and Hemolytic of Staphylococcus aureus through the GdpP Protein PMID 35234502
Reprogramming immunosuppressive myeloid cells facilitates immunotherapy for colorectal cancer PMID 33283987
SB
Synthesis and carbonic anhydrase inhibition studies of sulfonamide based indole
奥拉帕利杂质22
Isocytidine 489
Development of N
HPGDS inhibitor 3 2255311
Role of glutathione in the toxicity of the sesquiterpene lactones hymenoxon and helenalin PMID 3343693
Comprehending the mechanism of catechins against α
cytotoxic T
共694页
首页
上一页
491
490
489
488
487
486
485
484
483
482
481
下一页
尾页
生物活性分子
ICP证:
粤ICP备2021105330号-3
联系人QQ：9145908
返回首页
RSS更新