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Identification of metabolites of evobrutinib in rat and human hepatocytes by using ultra
Effects of short
Eplerenone a review of its use in patients with chronic systolic heart failure and mild symptoms PMID 23881669
(RS)
Beneficial effects of sampatrilat, a novel vasopeptidase inhibitor, on cardiac remodeling and function of rats with chronic heart failure following left coronary artery ligation PMID 12649357
Ghrelin promotes cardiomyocyte differentiation of adipose tissue‑derived mesenchymal stem cells by DDX17‑mediated regulation of the SFRP4/Wnt/β‑catenin axis PMID 37449526
Soft Extrudable Dendritic Particles with Nanostructured Tendrils for Local Adhesion and Drug Release to Bladder Cancers PMID 40611758
Comparative effects of indomethacin on cell proliferation and cell cycle progression in tumor cells grown in vitro and in vivo PMID 11239499
Mitochondrial
Identification of serotonin 2A receptor as a novel HCV entry factor by a chemical biology strategy PMID 29542010
KAR
Acute treatment with metformin improves cardiac function following isoproterenol induced myocardial infarction in rats PMID 23406758
Indacaterol inhibits tumor cell invasiveness and MMP
Blockade of JAK2 retards cartilage degeneration and IL
Mechanoresponsive Drug Loading System with Tunable Host
Cholesterol
Formation of the diuretic chlorazanil from the antimalarial drug proguanil
Isolation and bioactivities of constitutents of the roots of Garcinia atroviridis PMID 11473441
PPM1E 抗体 (YA6706)（PPM1E Antibody (YA6706)）
三氯苯哒唑
IMP701
ML240
Isosulfan blue (异硫蓝)
Parvifoline Derivatives as Tubulin Polymerization Inhibitors PMID 30883116
PSII
CTL
Convallatoxin (铃兰毒苷)
Omadacycline (PTK 0796)
FASN
甲硫蒽酮 (标准品)
铁鸠菊提取物 (Vernonia Schreb.)
Sodium Ion Channel Library
Antifolate
Hexokinase
Reactive Oxygen Species (ROS)诱导剂、基因
Hemoglobin 9008
Piretanide, a potent diuretic with potassium
Omadacycline (Standard) (PTK 0796 (Standard))
Omadacycline tosylate (PTK 0796 tosylate，奥马环素)
Convallatoxin (Standard) (铃兰毒苷 (Standard))
Dual
Structure
Cabralea eichleriana DC.提取物 (Cabralea eichleriana DC.)
Pulmonary vasoconstriction by serotonin is inhibited by S
Angelic acid (Standard) (当归酸 (Standard))
Eldecalcitol 104121
An Integrated Computational and Experimental Approach to Identifying Inhibitors for SARS
Ⅱ 型拓扑异构酶 (DNA topoisomerase II)
(±)14
AZD5099 907543
Shikonin induces ferroptosis in osteosarcomas through the mitochondrial ROS
Fluxapyroxad 907204
Pheneturide 90
Emodin induces ferroptosis in colorectal cancer through NCOA4
Tariquidar methanesulfonate, hydrate (XR9576 methanesulfonate, hydrate)
agrochemicals
Fatostatin induces ferroptosis through inhibition of the AKT/mTORC1/GPX4 signaling pathway in glioblastoma PMID 36966152
Mechanism of antidiuresis caused by bendroflumethiazide in conscious rats with diabetes insipidus PMID 9517394
Eugenol Attenuates Transmissible Gastroenteritis Virus
Peach Gum Polysaccharide Prevents Chemotherapy
弱阴离子交换层析介质 6FF (DEAE Agarose 6FF )
ortho
LLC355
Design, synthesis and evaluation of novel ErbB/HDAC multitargeted inhibitors with selectivity in EGFRT790M mutant cell lines PMID 33493830
Both direct and indirect suppression of MCL1 synergizes with BCLXL inhibition in preclinical models of gastric cancer PMID 40075071
Heme Oxygenase
Resibufogenin suppresses colorectal cancer growth and metastasis through RIP3
photodynamic therapy
Enoximone 77671
Deoxyribonuclease II 9025
Cholecystokinin
JAK
cardiac muscle contraction
Benzotript 39544
谷胱甘肽琼脂糖 (Glutathione Agarose )
100 bp DNA Marker (100 bp DNA Marker)
Tetrandrine 518
Detection of Chemical Engagement of Solute Carrier Proteins by a Cellular Thermal Shift Assay PMID 29851333
Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate，卡维地洛磷酸盐水合物)
Thioacetamide 62
Nitrosoglutathione 57564
抗耐药性化合物库
Zonisamide 68291
Bst DNA Polymerase, Full Length (Bst DNA Polymerase, Full Length)
Ex 591
immunomodulatory drug resistance
Rivabazumab pegol 1613506
Sulfometuron
Design, synthesis and biological evaluation of N
disease markers
Amino Acid Derivatives化学品、基因
Comprehensive multiscale analysis of lactate metabolic dynamics in vitro and in vivo using highly responsive biosensors PMID 38307980
热休克蛋白47 (Heat Shock Protein 47)
Ni
PGP 抗体 (YA6997)（PGP Antibody (YA6997)）
BRD9757 1423058
Co‑treatment with triptolide and RSL3 induces hepatocellular carcinoma cell apoptosis and ferroptosis PMID 40376993
Titanium dioxide nanoparticles induce apoptosis through ROS
Lyoniresinol 14464
50 bp DNA Marker (50 bp DNA Marker)
ML241 hydrochloride 2070015
uncultured bacteria
5,10,15,20
Autophagy is involved in Salmonella Typhimurium
Targeting tumor
Identification of novel SCD1 inhibitor alleviates nonalcoholic fatty liver disease critical role of liver
Research note Unveiling the impact of ovotransferrin on chicken primordial germ cells biological processes PMID 40359719
Antiproliferative activity of kinetin riboside on HCT
TAS
Discovery of a Novel Benzimidazole Derivative Targeting Histone Deacetylase to Induce Ferroptosis and Trigger Immunogenic Cell Death PMID 39145486
Deferoxamine B A Natural, Excellent and Versatile Metal Chelator PMID 34071479
Streptomyces sp
Novel β
Canrenoate potassium 2181
Prevention of PC12 cell death by N
Comparison of the Hydroxylase Inhibitor Dimethyloxalylglycine and the Iron Chelator Deferoxamine in Diabetic and Aged Wound Healing PMID 28234841
Selection of evodiamine as a novel topoisomerase I inhibitor by structure
Hydrogen sulfide protects Sertoli cells against toxicant Acrolein
Beta
Cisatracurium besylate rescues Mycobacterium Tuberculosis
OTSSP167 suppresses TNBC brain metastasis via ROS
Biphenyl
Discovery of selective HDAC/BRD4 dual inhibitors as epigenetic probes PMID 33077265
Patent Blue V (Acid blue 1)
ROS Reduction Does Not Decrease the Anticancer Efficacy of X
Divergent Evolution of Malignant Subclones Maintains a Balance Between Induced Aggressiveness and Intrinsic Drug Resistance in T Cell Cancer PMID 40516109
Resibufogenin and cinobufagin activate central neurons through an ouabain
Cardioprotective effects of rutin in rats exposed to pirarubicin toxicity PMID 29078725
New camptothecin derivatives for generalized oncological chemotherapy Synthesis, stereochemistry and biology PMID 34048881
Tom20 senses iron
Structural Requirements of HDAC Inhibitors SAHA Analogues Modified at the C2 Position Display HDAC6/8 Selectivity PMID 28337317
LY354740 Reduces Extracellular Glutamate Concentration, Inhibits Phosphorylation of Fyn/NMDARs, and Expression of PLK2/pS129 α
Autophagy
Nitrosoglutathione promotes flap survival via suppression of reperfusion injury
Recent advances of podophyllotoxin/epipodophyllotoxin hybrids in anticancer activity, mode of action, and structure
Auranofin Induces ER Stress
Estrogen
Eremophilane sesquiterpenes from agarwood of Aquilaria agallocha with neuroprotective effect PMID 40306531
Potent antiproliferative activity of bradykinin B2 receptor selective agonist FR
P
Design, Synthesis, and Biological Evaluation of HSP90 Inhibitor
CGCG/CGG ligand 1
Cullin 2
(
Development of N
IL
HOE 33187
TAGLN2 Exacerbates Acute Pancreatitis
Celastrol induces ferroptosis by suppressing RRM2 in hepatocellular carcinoma PMID 39071636
8
A Near
Targeting the SP/KLF Transcriptional Regulatory Network Synergizes with HDAC Inhibition to Impede Progression of H3K27M Diffuse Intrinsic Pontine Glioma PMID 40053472
PIEZO1
Estimation of liver function using T1 mapping on Gd
Pan
Glutathione S
Paneth Cells Protect against Acute Pancreatitis via Modulating Gut Microbiota Dysbiosis PMID 35491818
N
Vorinostat, a pan
P
dTAGV
Ethylphenacemide (Standard)
Omadacycline mesylate (PTK 0796 mesylate)
DL
Apelin
Rubidazone vs adriamycin an evaluation of their differential toxicity in the spleen colony assay system PMID 952715
Diuretics in the treatment of hypertension. Part 1 thiazide and thiazide
High glucose suppresses autophagy through the AMPK pathway while it induces autophagy via oxidative stress in chondrocytes PMID 34006821
Inotuzumab ozogamicin 635715
Phase I and pharmacokinetic study of 3'
ERK Inhibitor II (Negative control) 1177970
Using combination therapy to override stromal
A small
Gum arabic (Arabic gum，阿拉伯胶)
TROP
SARS
LACTB suppresses liver cancer progression through regulation of ferroptosis PMID 39047638
(
Carbamazepine is an inhibitor of histone deacetylases PMID 15850602
Selective Akt inhibitors synergize with tyrosine kinase inhibitors and effectively override stroma
Branched
Amonafide 69408
Low
Tetrahydropyrido[4,3
Degradation of HDAC10 by autophagy promotes IRF3
Iron increases lipid deposition via oxidative stress
Dual
白细胞免疫球蛋白样受体 B2（LILRB2）基因
Protocatechuic Acid Improves Alzheimer's Disease by Regulating the Cholinergic Synaptic Signaling Pathway PMID 39776239
MAT2A inhibitor 5
Nrf2
Computational and synthetic studies towards improving rescinnamine as an inducer of MSH2
Methylcobalamin protects against liver failure via engaging gasdermin E PMID 39890804
Histone hyperacetylation mediates enhanced IL
Rotenoids and flavonoids with anti
Synthesis and biological evaluation of novel histone deacetylases inhibitors with nitric oxide releasing activity PMID 26122774
Restoration of p53 acetylation by HDAC inhibition permits the necrosis/apoptosis switch of pancreatic ainar cell during experimental pancreatitis in mice PMID 31058328
Advances in aluminum hydroxide
Rosmarinic acid alleviate CORT
TLR3 Ligand PolyI C Prevents Acute Pancreatitis Through the Interferon
Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface
Localization of a TORC1
N
(±)13
A cell
Brucella induces heme oxygenase
Molecular Imaging and In Situ Quantitative Profiling of Fatty Acid Synthase with a Chemical Probe PMID 32053360
Cinnamaldehyde Alleviates Bone Loss by Targeting Oxidative Stress and Mitochondrial Damage via the Nrf2/HO
Life Chemicals CNS Focused Screening Library
裂叶蒿提取物 (Artemisia tanacetifolia L.)
Recent updates on novel therapeutic targets of cardiovascular diseases PMID 32845435
Structure
[Thr28, Nle31]
Metoprolol tartrate 56392
Calcitonin Gene Related Peptide (CGRP) II, rat
Discovery of 1,2,4
Anthocleista djalonensis
Synthesis and biological evaluation of novel thiocolchicine
Arylsulfatase
Brain
Activity of TAS4464, a novel NEDD8 activating enzyme E1 inhibitor, against multiple myeloma via inactivation of nuclear factor κB pathways PMID 31583781
Inhibitory activities of gatifloxacin (AM
Hxk2VBD peptide, cell
Type II diabetes mellitus
Design, synthesis, and evaluation of pyrido.[3,4
Biotin
Fate induction in CD8 CAR T cells through asymmetric cell division PMID 39198645
Design, synthesis and evaluation of antiestrogen and histone deacetylase inhibitor molecular hybrids PMID 26613635
Patient
Effective Inhibition of MYC
Peroxisome proliferator
Piper aurantiacum
4β
Amlodipine aspartic acid impurity
Synthesis and structure
WTAP/YTHDF1
Di
Angelic acid (当归酸)
Design, synthesis and biological evaluation of 2,3
Development of oxoisoaporphine derivatives with topoisomerase I inhibition and reversal of multidrug resistance in breast cancer MCF
SYK is a critical regulator of FLT3 in acute myeloid leukemia PMID 24525236
PI3K/AKT/mTOR, NF
L
Vemtoberant mesylate 2169905
Synergistic effects of autophagy/mitophagy inhibitors and magnolol promote apoptosis and antitumor efficacy PMID 35024319
Ramelteon metabolite M
Quinazoline
The Xc
(±)8
SIRT6 promotes angiogenesis and hemorrhage of carotid plaque via regulating HIF
Elevated Angiotensin
Design, synthesis, and AChE inhibitory activity of new benzothiazole
Synthesis and anticancer activity of heteroaromatic linked 4β
Downregulation of BDNF mRNA and protein in the rat hippocampus by corticosterone PMID 9824681
Bendroflumethiazide 73
A live
The tryptophan metabolite 3
Silibinin Inhibits Cell Ferroptosis and Ferroptosis
Synthesis, biological characterization and molecular modeling insights of spirochromanes as potent HDAC inhibitors PMID 26629860
SNORA28 Promotes Proliferation and Radioresistance in Colorectal Cancer Cells through the STAT3 Pathway by Increasing H3K9 Acetylation in the LIFR Promoter PMID 38924373
Design and synthesis of tranylcypromine derivatives as novel LSD1/HDACs dual inhibitors for cancer treatment PMID 28987602
ROS induced the Rab26 promoter hypermethylation to promote cigarette smoking
HO
Modeling NK
para
MAT2A inhibitor 4
Identification of WNK1 as a therapeutic target to suppress IgH/MYC expression in multiple myeloma PMID 38722741
The effects of cisplatin and jaceosidin on SH
Discovery of aliphatic
毒豆提取物 (Laburnum anagyroides Medic.)
Soluble guanylate cyclase stimulator praliciguat attenuates inflammation, fibrosis, and end
Inhibitory effects of Eplerenone on angiogenesis via modulating SGK1/TGF
Gold(III) macrocycles nucleotide
Praliciguat inhibits progression of diabetic nephropathy in ZSF1 rats and suppresses inflammation and apoptosis in human renal proximal tubular cells PMID 32865013
Pheneturide (Standard)
Design, synthesis, and biological evaluation of novel HDAC inhibitors with a 3
Aluminum Hydroxide 21645
Cholecystokinin regulates atrial natriuretic peptide secretion through activation of NOX4
Design, synthesis and tumor cell growth inhibitory activity of 3
Heme oxygenase
Lighting up arginine metabolism reveals its functional diversity in physiology and pathology PMID 39413790
In Vivo Metabolism of Aristolochic Acid I and II in Rats Is Influenced by Their Coexposure PMID 32894017
Design, Synthesis, and Biological Evaluation of the First c
Verapamil attenuates myocardial ischemia/reperfusion injury by inhibiting apoptosis via activating the JAK2/STAT3 signaling pathway PMID 39405898
eIF4A alleviates the translational repression mediated by classical secondary structures more than by G
Chemical modifications of ergostane
Scopolamine 51
DNA聚合酶 I (E.coli) (DNA Polymerase I(E.coli))
An Integrative Proteome
Design, synthesis and screening of 1, 2, 4
EGFR
Lenalidomide hydrochloride (CC
MMP
K
hyperosmotic
Eletriptan
PRDX3(103
MHC I抑制剂、 Ligand、基因
Pgp Rat Pre
reader
Kumujian A (1
PI
NIR
Chemspace Scaffold derived set
ischaemia
peripheral
Irinotecan hydrochloride ((+)
Angiotensin II human (Angiotensin II，血管紧张素Ⅱ)
mTOR Inhibitors
PIK
AZD 9898
N
EAAT Inhibitors
凯福隆氨噻肟头孢菌素钠
Moxidectin (CL301423，莫昔克丁)
DIM
Dextran T3 (MW 3,000) (Dextran 3，右旋糖酐T3(MW 2400
Hit Locator Library
MGD 013
CDK9 degrader
HMG
L
Poly(guluronate), low endotoxin
Manzamine A hydrochloride (Keramamine A hydrochloride)
tetramisole
Vismodegib (GDC
CCR4抑制剂、拮抗剂、化学品、基因
Anaplastic lymphoma kinase (ALK)
Oritavancin diphosphate (Standard) (LY333328 diphosphate (Standard)，奥利万星二磷酸盐(Standard))
HEPES (HEPES)
PROTAC EGFR degrader 3
LysoSensor PDMPO
HDAC10
CYP4Z1
离子通道 (Ion Channel Modulators)
Fosfomycin (MK
二肽 (Dipeptides)
Fmoc
VD/VDR调节剂、基因
TRPV1
2',5'
Cyclo(Arg
Technical Support
BRD4/FKBP12 degrader
FAAH调节剂、基因
Hoechst 33342 analog 2 trihydrochloride
CDK9/EZH2
2
Bicuculline ((+)
Calicheamicin (Calicheamicin γ1，卡奇霉素)
L
ADAM10抑制剂、基因
15(R)
Podofilox 518
跨膜 4 域，亚科 A，成员 1（Ms4a1）基因
Lorglumide sodium salt 1021868
PBS Powder (2 L of 1×) (PBS Powder (2 L of 1×))
Gatifloxacin sesquihydrate (AM
Novel Peptide
谷胱甘肽琼脂糖磁珠 (Glutathione Magnetic Agarose Beads)
trans
Technical Support
登录
Bulevirtide (Myrcludex B)
HBV Control、基因
XIAP抑制剂、拮抗剂、诱导剂、降解剂、基因
补体受体 2 (CD21/CR2)
Metformin inhibits glycogen synthesis and gluconeogenesis in cultured rat hepatocytes PMID 12681026
Hepatitis E Virus (HEV)
Animal
A novel piperazine linked β
PAK
Polylactic acid based polymeric nanoparticle mediated co
Rapamycin can alleviate the submandibular gland pathology of Sjögren's syndrome by limiting the activation of cGAS
Targeting p38γ synergistically enhances sorafenib
Nebivolol 118457
Cytoglobin augments ferroptosis through autophagic degradation of ferritin in colorectal cancer cells PMID 39503803
Chaetocin disrupts the SUV39H1
Targeting the LMP1
Fingolimod suppresses neuronal autophagy through the mTOR/p70S6K pathway and alleviates ischemic brain damage in mice PMID 29186197
Lys29
Oleuropein, the Main Polyphenol of Olea europaea Leaf Extract, Has an Anti
ionophore
ABT263
protein epitopes
chemo
Mitochondrial Metabolism
IL
6
warts
multidrug resistance
Taxifolin improves disorders of glucose metabolism and water
Casein Kinase
COX
CALP1
REGN
Olodanrigan (EMA401)
NDRG1 抗体 (YA274)（NDRG1 Antibody (YA274)）
GS9674
Adenosine
Nectin
CD85e/LILRA3
LVN neuron
transcription
MEK
rac
Fenoterol hydrobromide (Standard) (Th
CCR
加纳籽凝集素II, 生物素化
Toyocamycin 606
Bruton tyrosine kinase
α
Riociguat 625115
巯基偶联琼脂糖凝胶 (High
ARN24139 2699768
Sodium oligomannate activates the enteroendocrine
LAMP2 抗体 (YA6257)（LAMP2 Antibody (YA6257)）
Bis(N
肝素琼脂糖 6FF (Heparin Agarose 6FF)
Nifedipine 21829
Topoisomerase抑制剂、基因
DPP4 Inhibitor Attenuates Severe Acute Pancreatitis
S. uirgaurea L
SPB07935 634190
PGP9.5 抗体 (YA6265)（PGP9.5 Antibody (YA6265)）
Copper(II) perchlorate hexahydrate 10294
Cholera toxin B subunit, from vibrio cholerae 131096
2
Melia volkensii Gürke提取物 (Melia volkensii Gürke)
非天然氨基酸库
LP17
Cefotaxime sodium 64485
Pristinamycine
岭南楝树提取物 (Melia dubia Cav.)
Quazomotide 935395
L
Bovine Serum Albumin (Low Endotoxin,Fatty acid free) (Albumin bovine serum (Low Endotoxin,Fatty acid free))
alpha Synuclein 抗体 (YA2073)（alpha Synuclein Antibody (YA2073)）
Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V solution and X
CNTFR alpha 蛋白, Human (sf9, His)
MRTX1133 2621928
Caerulein 17650
Ni
Trastuzumab (anti
CD38
IgG1λ monoclonal antibody
RANKL/TNFSF11 蛋白, Human (HEK293, mFc)
PH20
CCR9拮抗剂、基因
MCF
Imperatorin (Ammidin，欧前胡素)
PEG 23 lauryl ether
Cholinesterase (ChE)
Acotiamide monohydrochloride trihydrate
Nucleoprotein/NP 蛋白, Influenza B virus (His
RPR121056 (APC)
Cd74
D
The combination of nuclear receptor NR1D1 and ULK1 promotes mitophagy in adipocytes to ameliorate obesity PMID 35410572
HA1/Hemagglutinin 蛋白, H5N1 (ACA47835, HEK293, His)
HA/Hemagglutinin 蛋白, H1N1 (EPI2397519, sf9, His)
Identifying the p65
Vitamin D3 mediates autophagy to alleviate inflammatory responses in bovine endometrial epithelial cells and organoids via the PI3K/AKT/mTOR pathway PMID 39418864
Microglia TREM1
Ultrabright ratiometric Raman
The new pattern for dual NOTCH pathway involving nuclear transcription and mitochondrial regulation supports therapeutic mechanism of 4
LINC00858 stabilizes RAN expression and promotes metastasis of gastric cancer PMID 36528654
Heat shock protein A1 inhibits the replication of foot
BMAL1 ameliorates type 2 diabetes
Protective Effects of Dexmedetomidine on Sepsis
Repurposing Brigatinib for the Treatment of Colorectal Cancer Based on Inhibition of ER
Brilaroxazine (Standard)
Chaetocin 28097
Ex 380 nm 紫外激发光荧光探针 (Ex 380 nm Ultraviolet)
A secretome atlas of cardiac fibroblasts from healthy and infarcted mouse hearts PMID 40301568
TRPV1 抗体 (YA6814)（TRPV1 Antibody (YA6814)）
Cigarette smoke extract induces apoptosis of rat alveolar Type II cells via the PLTP/TGF
Pamiparib 1446261
PDGF
Enoxacin hydrate 84294
The angiogenic properties of human amniotic membrane stem cells are enhanced in gestational diabetes and associate with fetal adiposity PMID 34930438
Sodium carboxymethyl cellulose (Viscosity 800
Neuraminidase 1 promotes renal fibrosis development in male mice PMID 36973294
The liver microenvironment orchestrates FGL1
Synergistic antitumor effect of brusatol combined with cisplatin on colorectal cancer cells PMID 29328398
Workflow for Performing Genetic Manipulation in Human Trophoblast Stem Cells Using CRISPR/Cas9 Technology PMID 36515893
Radiation
Cell
Sorbitol dehydrogenase 9028
ITGA2 induces STING expression in pancreatic cancer by inducing DNMT1 degradation PMID 36331797
褐藻提取物 (Brown seaweed)
Novel berberine
1α,25
Tisotumab (powder)
Discovery of new hit
Gamma synuclein promotes cancer metastasis through the MKK3/6
Bisphenol F suppresses insulin
Hoechst 33342 analog trihydrochloride 159277
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